Coagulation

Question 1

Which factors does Vit K and Warfarin toxicity interfere in the coagulation cascade?

Answer 1

Factors 2, 9, 7, 10

Protein C and protein S in the liver

Question 2

Where vWF originate from? (2)

Answer 2

Megakaryocytes

endothelial cells

Question 3

Four strongest anti-coagulative factor?

Answer 3

antithrombin, trombine-thrombomodulin complex, protein S, protein C

Question 4

Tests of intrinsic and extrinsic pathways?

Answer 4

Intrinsic: ACT (activating clotting time), APTT
Extrinsic: PT, PIVKA (proteins induced by Vit K antagonism)
Common: TT (Thrombin time)

Question 5

What is the most important anticoagulant found in plasma?

Answer 5

Antithrombin

Question 6

What is hemophilia B?

Answer 6

Christmas disease, factor IX deficiency, x-linked rescessive inheritance

Question 7

What is hemophilia A?

Answer 7

Factor VIII deficiency, x-linked recessive inheritance, males

Question 8

What is hemophilia C?

Answer 8

Factor XI deficiency, autosomal dominant inheritance

Question 9

What is considered as a platelet agonist?

Answer 9

Thrombin

Question 10

What factors are involved in intrinsic pathway?

Answer 10

APTT, ACT, factor 8, 9, 11, 12

Question 11

What factors are involved in extrinsic pathway?

Answer 11

PT, PIVKA, factor 3, 7