Coagulation Flashcards
What are the three Major systems involved with coagulation?
- Vessel wall
- Endothelium: Slippery so cells don’t stick
- Basement membrane: Endo attached to this - Platelets
- Coagulation cascade
- Coag factors (proteins)
The endothelium is slippery and keeps things ____ through a series of chemical processes. This keeps the platelets in an ____ state.
- Moving
- Inactive state
Antithrombotic properties of the endothelium is…
The endothelium is slippery and keeps things moving through a series of chemical processes. This keeps the platelets in an inactive state.
Hemostasis in regards to coagulation is keeping the blood ___.
Blood flowing, blood flow
What are three things coagulation (clotting) at the proper time needs in order to do this?
- Needs to be rapid
- Localized
- Reversible!!
Thrombosis means…
“Blood clot”
This is the official word for it
Anticoagulant properties are ____-like molecules. These activate anti-thrombin III. Basically, it ____ active proteases.
- Heparin-like molecules
- Inactivates active proteases.
- Proteases play a role in clotting cascade
Name the two phases of coagulation
- Mechanical
- Chemical
Coagulation’s Mechanical phase is the ____ of the vessel. ___ are attracted to the damaged endothelium of the blood vessel.
Now, platelets attach to the ___ and ___ ___. They release ____.
- Vasoconstriction of the vessel
- Platelets are attracted to the damage
- Endothelium and each other (they attach to)
- Thromboxane is released by the platelets
T/F: Coagulation’s Chemical phase is essential for blood vessels as they are much larger than capillaries.
True
Chemical phase is also called the “Coagulation Cascade.”
List the three pathways and the outcome from them.
- Intrinsic pathway
- Extrinsic pathway
- Common pathway
- Outcome: FIBRIN!!
T/F: Less than half of the clotting factors are made in the liver
False! All of them are made in the liver (like vitamin K)
List five inhibitors of coagulation
- Vitamin K antagonists
- EDTA
- Citrate
- Oxalate
- Heparin
List two birth defects that can affect coagulation
- Hemophilia
- Von Williebrands
List some acquired disorders/diseases that affect coagulation (5)
1.Rodenticide: Rat poison
2. Thrombocytoenia: Tick borne, etc
3. Liver failure: Liver helps w/clotting!
4. Disseminated Intravascular Coagulation (DIC): Commonly sepsis
5. Snake bites! Ooo WA AH AH AHH
