Coaeliacs disease Flashcards
1
Q
when do children usually present?
A
before the age of 3 years, following the introduction of cereals into the diet
2
Q
which genes are they strongly associated with?
A
HLA-DQ2 (95% of patients) and HLA-DQ8 (80%)
3
Q
what are the features?
A
failure to thrive
diarrhoea
abdominal distension
older children may present with anaemia
many cases are not diagnosed to adulthood
4
Q
diagnosis
A
jejunal biopsy showing subtotal villous atrophy
anti-endomysial and anti-gliadin antibodies are useful screening tests
