ACUTE LYMPHOBLASTIC LEUKAEMIA

Question 1

What percentage of childhood leukaemia does ALL accounts for?

Answer 1

80%

most common

Question 2

What is the peak age range?

Answer 2

2-5 years old

Question 3

What sex is more affected?

Answer 3

males

Question 4

What are the most common features of ALL?

Answer 4

features common with bone marrow failure:

1. anaemia - lethargy and pallor
2. neutropenia frequent or severe infections
3. thrombocytopenia - easy bruising or petechiae

Question 5

What are the other features of ALL?

Answer 5

1. bone pain
2. splenomegaly
3. hepatomegaly
4. fever
5. testicular swelling

Question 6

What types of ALL are there?

Answer 6

1. common ALL
2. T cell
3. B cell

Question 7

What percentage of ALL is common ALL?

Answer 7

75%

Question 8

What immune cells/genetics are involved in Common ALL?

Answer 8

CD-10

pre-b phenotype

Question 9

What percentage of ALL is T cell ALL?

Answer 9

20%

Question 10

What percentage of ALL is B cell ALL?

Answer 10

5%

Question 11

What are poor prognostic factors of ALL?

Answer 11

1. age < 2 years or age > 10 years
2. WCC > 20x 10^9 at the time of diagnosis
3. T or B cell surface markers
4. Non caucasian
5. Male