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Systemic Pathology > Cns Pathology > Flashcards

Cns Pathology Flashcards

1
Q

Types of gliomas

A

Astrocytomas
Oligodendroglioma
Ependymoa

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2
Q

80percent of primary brain tumours

A

Diffuse astrocytomas

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3
Q

Sites of diffuse astrocytomas

A

Cerebral hemispheres
Cerebellum
Brain stem
Spinal cord

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4
Q

Sites of oligodendrogliomas

A

White mater of cerebral hemisphere

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5
Q

Sites of meningiomas

A

Anywhere on external surface or ventricular system of brain
M.c site >para saggital regions of cerebral hemisphere
Dura over lateral convexity,olfactory groove

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6
Q

Sites of schwannoma

A

Cerebellopontine angle
Peripheral angle

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7
Q

Site of medulloblastomas

A

Cerebellum

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8
Q

Verocay bodies

A

Nuclear palisading both upper and lower sides and a central anuclear zone

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9
Q

Psammoma bodies show which type of calcification

A

Dystrophic

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10
Q

Psammoma bodies present in which brain tumours

A

Meningiomas

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11
Q

Homer wright rosettes present in

A

Medulloblastomas

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12
Q

Malignant but no metastatic tumours

A

Gliomas
Basal cell carcinoma

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13
Q

Tumor grading based on

A

AMEN
A-atypia
M-mitotic count
E-endothelial proliferation
N- necrosis

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14
Q

Every glial original tumor shows what positive

A

IHC - GFAP positive
Glial fibrillary acidic protein

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15
Q

Main features of oligodendrogliomas

A

Chicken + egg
Chicken wire appearance +fried egg appearance
Capillary network +halo around nucleus

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16
Q

Genes involved in diffuse astrocytomas

A

IDH1 and IDH 2
ATRX,TP53 mutation

17
Q

Genes involved in oligodendrogliomas

A

Codeletion of 1p/19q
IDH1,IDH2 mutation

18
Q

Genes involved in meningiomas

A

NF2 gene
Chromosome 22q12 deletion

19
Q

Immunohistochemistry of meningiomas

A

GFAP negative
Epithelial membrane antigen EMA positive
Vimentin positive

20
Q

Genes in medulloblastomas

A

Wnt pathway or beta catenin
Sonic hedge hog SHH mutation

21
Q

Why meningiomas grow during pregnancy

A

Have progesterone receptor

22
Q

Schwannoma immunohistochem

A

S 100
CD 34

Systemic Pathology (8 decks)

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