CNS - Drugs for antidepressants Flashcards
what do SSRIs stand for?
Selective Seretonin Reuptake Inhibitors
What are the SSRIs?
Fluo|xetine
Paro|xetine
Ser|tara|line
Cita|lopram
ES|citalopram
what is the MoA of SSRIs?
block serotonin reabsorption into presynaptic nerve ending
= increase [serotonin] in synaptic cleft
= increase serotonin activity at the post synaptic receptor sites
what are the adverse effects of SSRIs
nausea
headache
weight loss & gain
anxiety
sexual dysfunction
**no fatility in OD
what does SNRIs stand for
serotonin norepinephrine reuptake inhibitors
what are the SNRI drugs?
vena|flaxine
tra|zodone
nefa|zodone
what are the TCA drugs?
amitriptyline
imi|pramine
what are the side effects of the TCAs and SNRIs?
CNS - sedation, fatigue
CVS - tachycardia, arrhythmia, postural hypotension
anticholinergic effects -
definition of anticholinergic
block acetylcholine
= cannot have parasympathetic NS