CNS Development Flashcards

1
Q

when does the human brain begin development?

A

during week 3

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2
Q

what can be caused If placental function is lacking?

A

IUGR

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3
Q

when is the embryonic period?

A

from conception to week 9

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4
Q

what are the initial two layers of the embryo?

A

epiblast

hypoblast

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5
Q

what is found in the middle of the two layered embryo?

A

primitive streak

primitive node

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6
Q

what are the three layers of the three layered embryo/

A

ectoderm
mesoderm
endoderm

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7
Q

what does the ectoderm form?

A

skin
nails
hair
neural tissue

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8
Q

what does the mesoderm form?

A

muscle
bone
cartilage
vascular system

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9
Q

what does the endoderm form?

A

gut

respiratory system

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10
Q

what embryonic layer forms the neural tissue?

A

ectoderm

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11
Q

what is the first well defined neural structure that forms?

A

the neural tube

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12
Q

when does the neural tube form?

A

between days 20 - 27

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13
Q

how does the neural tube form?

A

neural progenitor cells form the neural plate, which folds in on itself to form the mural tube

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14
Q

what lines the inside of the neural tube?

A

neural progenitor cells

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15
Q

what is the inside of the neural tube called?

A

the ventricular zone

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16
Q

what does the hollow centre of the neural tube form?

A

ventricular system

central channel of the spinal cord

17
Q

what does the rostral part of the neural tube form?

A

the brain

18
Q

what does the caudal part of the neural tube form?

A

the spinal cord

19
Q

when is the foetal period?

A

from week 9 til term

20
Q

what determines the differentiation of neural tissue in the foetal period?

A

signalling molecules

21
Q

what signalling molecules determines the function of neurones in the foetal period?

A

emx2

pax6

22
Q

what do progenitor cells become when there is high Pax6 and low Emx2?

A

motor neurones

23
Q

where are more motor neurones located?

A

the anterior brain

24
Q

what do progenitor cells become when there is low Pax6 and high Emx2?

A

visual cortical neurones

25
Q

where are more visual cortical neurones found?

A

the posterior brain

26
Q

what is a smooth brain called?

A

lissencephaly

27
Q

how does the brain start?

A

very smooth

gradually developed its folds

28
Q

how do the sulci and gyri develop sequentially?

A

primary sulci
secondary sulci
tertiary sulci

29
Q

what do neural progenitor cells divide into?

A

initially = two identical neural progenitor cells

then into one progenitor cell and one neuron

30
Q

can neurones divide?

A

no

31
Q

how many layers make up the neocortex?

A

six