CNS/ANS Flashcards
What is grey matter ?
“Nuclei” in cortices, ganglia outside CNS
Where is white matter?
Tracts in CNS, nerves outside CNS
The brain weighs about 1/70th of the body but receives _____% of the blood
20
What are the different tracts?
Projection - Low <—-> High
Association - Short connections
Commisural - L. Hemisphere <–> R. Hemisphere (largest is corpus collosum
What do tracts do?
Connect one part of the CNS to another
How is the CNS protected?
Bone (skull, vertebrae)
Layer of Meninges
Epidural Space
Dura matter
Subdural space
Arachnoid Matter
Subarachnoid space – where CSF is
Pia Matter (touches sulci of brain)
Where is cerebrospinal fluid (CSF) and what does it do?
In the subarachnoid space
Gives buoyancy to brain and spinal cord so they are not damaged by their own weight
Cushions and protects
Blood Brain Barrier
Transports Materials
What is the Blood Brain Barrier and what is its purpose?
Maintains a constant environment for the brain by being extremely selective
Created by the foot processes of astrocytes
What material can pass the Blood Brain Barrier?
Lipid Solubles, Glucose, select ions and aminos
What are the metabolic requirements of the brain?
A constant supply of oxygen and glucose
How and why is glucose transported to the brain?
How - via plasma by insulin-independent membrane transporters
Why - for ATP
Note: This is why hypoglycemia leads to death and confusion
What are the regions of the brain?
Cerebrum
Diencephalon
Epithalamus (pineal gland)
Thalamus
Hypothalamus (pituitary gland)
Brainstem
Midbrain
Pons
Medulla Oblongata
How can the brain be modified?
Use-dependent competition (neuroplasticity)
What are the functional areas of the brain?
Sensory Area
Motor Area
Association Areas (al the rest)
Shat is the cerebral cortex made out of?
Grey matter
Why is the cerebral cortex highly convoluted?
(Ask for clarification)
What 2 channels opening cause an IPSP?
Chloride (-) and Potassium (+)
What is the term for action potential conduction on myelinated fibers?
Saltatory conduction
What NT causes vessel dilation and erectile tissue enlargement?
Nitric Oxide
Where is the lower motor neuron found?
The ventral/anterior horn
What are the effectors of the system that passes through the ventral/anterior horn of the spinal column?
Skeletal Muscles (It’s the motor system)
What are the somatosensory modalities?
Touch, Pain, Pressure, Temperature, Proprioception
What part of the brain is responsible for personality?
Prefrontal cortex
What is the specific location of the 1st, 2nd, and 3rd order sensory neurons?
1st: Dorsal Root Ganglion
2nd: Dorsal Horn
3rd: Thalamus
What part of the brain tells the hypothalamus to fight or flight?
Cortex
Which is the language area deficit where a victim can speak but does not know they are not making sense?
Wernicke’s area
Why is the SCN names the way it is?
The Suprachiasmic Nucleus is a nucleus on top of (supra) the optic chiasm
What does the SCN make and secrete that is relevant to its function?
Meltonin
What do Afferent neurons transmit?
Sensory Information
What do efferent neurons transmit?
Motor impulses
What does the corticospinal tract transmit?
Motor informarion
What cells form myelin sheaths?
Schwann cells in PNS
oligodendrocites in CNS
From where do somatic instructions originate?
The primary motor cortex of the prefrontal cortex
Excessive function of what brain region causes excessive muscle tone and mask face?
Basal Nuclei (the disease is Parkinson’s)
Damage to the hippocampus would result in what?
memory loss
Where are the upper motor neurons?
The precentral gyrus
Where are the lower motor neurons?
Anterior/Ventral Horns of the spinal column
Where is the somatosensory cortex?
The Parietal lobe
What are the cleanup crew cells of the CNS?
Microglial cells
Damage to what structure may cause a coma?
Reticular Formation
What is the body’s clock?
The Suprachiasmic Nucleus
What spinal damage causes paraplegia?
Thoracic 1 down
What spinal damage causes quadriplegia?
C1 down
What causes motor aphasia?
Damage to Broca’s area
What enzyme breaks down catecholamines?
Monoamine oxidase
What breaks down ACh?
Acetylcholinase
What causes vesicles to move to the synaptic cleft?
AP moves down the presynaptic neuron, depolarizing the axon, opening up voltage gated Ca2+ channels then Ca2+ flows into the axon, releasing vesicles into the synaptic cleft
What types of transmission uses the spinothalamic tract?
Pain and temperature
What NT is used in almost all neuromuscular junctions?
Acetylcholine
What brain region receives input from proprioceptors, visual receptors, and other sensory regions in order to do its job
The cerebellum
What are the the three voltage-gates channels that open during an AP (in order)
Sodium (Na)
Potassium (K)
Calcium (Ca)
What are the class of receptors that ACh can bind to?
Muscarinic receptors
What type of channel is mostly found on cell bodies and dendrites?
Ligand-gates channels
What controls the ANS?
Hypothalamus
What is meant by dual innervation?
An organ receives an input from both the sympathetic and parasympathetic divisions for a variety of functions and precise control.
Ex. The heart: parasymp decrease hr; symp increase
What organs, tissues, and glands are innervated only by sympathetic nervous system?
Sweat glands, arrector pili. blood vessels
What major cranial nerve carries PSNS teansmission through abdominal and throaci cavities?
Vagus Nerve
What class of drugs affects the SNS?
Sympathomimetic
Give an example of a sympathomimetic drug and its effects
Tricyclic antidepressants: prolong the effects of norepinephrine on postsynaptic membranes
What class of drug decreases the effects of the SNS?
Sympatholytic
Name a sympatholytic drug and its effects
Beta blockers block cardiac B1 receptors which decreases HR and blood pressure
What is the class if drugs that decrease the effects of the PSNS?
Parasympatholytic
Name a parasympatholietic drug and its effects
Atropine dampens the PSNS by blocking a muscarinic receptors. Increases heart tate and urinary retention
What receptor increases HR?
What is its neurotransmitter?
What division of the ANS?
B1
NE/epinephrine
SNS
What receptor type decreases HR?
What is the neurotransmitter?
What division is involved?
What nerve is involved?
Muscarinic
ACh
Vagus
PSNS
What receptor decreases (constricts) blood vessels? What NT? What division?
A1
NE/epinephrine
SNS
Blocking the re uptake of what js a function of SSRI anti-depressants
Seratonin
What important ANS reflex center works closely with the hypothalamus?
Brain stem
Why are the effects if the SNS more widespread?
Fight or flight is a “whole body” response so more systems and tissues are affected by it
Why are the effects of the SNS longer?
Norepinephrine is inactivated much more slowly than ACh and remains circulating until it is destroyed by the liver
What receptor type dilates bronchioles?
B2
What is the biggest nerve of the PSNS?
Vagus
Which ANS div increases heart rate?
Sympathetic
Which ANS div decreases HR?
Parasympathetic
Which ANS division moves extrinsic eye to scan the horizon?
Neither
Which ANS division increases the release of lacrimal secretions from the eye?
Parasympathetic
Which ANS dic decreases saliva secretion?
Sympathetic
Which ANS dic dilates/relaxes bronchiolar smooth muscles?
Sympathetic
Which ANS div increases bladder contraction?
Parasympathetic
Which ANS div causes an increase in sweating?
Sympathetic
Which ANS div decreases digestive secretions and motility?
Sympathetic
What ANS system causes hepatocytes to break down glycogen and release glucose?
Sympathetic
What ANS division causes storage of fats and sugars
Parasympathetic
What ANS division increases lipolysis?
Sympathetic
What ANS division causes the lens to change shape for distance vision?
Sympathetic
What ANS division causes an increase in digestive motility and secretion?
Parasympathetic
What ANS system decreases vessel diameter in limbs, body wall, reproductive viscera?
Sympathetic
What division of the ANS controls contraction of CIRCULAR muscles of iris (pupil constriction)
Parasympathetic
What division of the ANS controls contraction of the RADIAL muscles of the iris (pupil dilation)?
Sympathetic
Which division of the ANS controls the cilliary body muscle?
Parasympathetic
Which division of the ANS uses ONLY muscarinic receptors at effectors?
Neither :P
Which division of the ANS uses muscarnic receptors at ganglia?
Neither
Which division of the ANS uses both muscarinic and adrenergic receptors?
Sympathetic
Which division of the ANS uses alpha receptors at ganglia?
Synpathetic
Which division if the ANS uses adrenergic receptors at ganglia?
Neither
Which division of the ANS causes release of nitric oxide at erectile arteries?
PNS
Which division of the ANS dominates during ejaculation?
Sympathetic
Which division if the ANS increases salivary gland secretions?
Parasympathetic
Which division of the ANS is responsible for the activation of the adrenal medulla?
Sympathetic