CNS Flashcards
Functions of the Nervous System
- Sensory input: helps us to feel things, like pressure and pain
- Motor output: helps us to move our skeletal muscles
- Integration: integrate those two things tgthr
Central Nervous System (CNS)
- includes: brain and spinal cord
- functions: integration, processing, and coordination of sensory input and motor commands, higher functions (intelligence, memory, learning, emotion)
Peripheral Nervous System
- includes: neural tissue outside brain and spinal cord (cranial nerves, spinal nerves, ganglia)
- functions: links all regions of body to CNS (can’t have a memory to hold something w/o the peripheral NS), delivers sensory info to CNS, carries motor commands to peripheral tissues
- it delivers memories and sensations to the brain
What two sections are apart of the PNS?
- Sensory (Afferent)
- bring info IN to CNS
- info is going At the brain
- Motor (Efferent)
- sends info OUT of CNS
- E for exiting
Neuroglia
- supporting cells
- catering to every whim of our neuron
Ependymal cells
- simple cuboidal epithelium lining ventricles
- will make CSF
Microglia
- phagocytes of the CNS
- come in and gobble up any foreign invaders
- gobble up any waste tissue or scar tissue
Astrocytes
- structural and nutritional support for form blood-brain barrier (star-shaped cell)
Oligodendrocytes
- produce myelin for the CNS (cell with few branches)
Dendrites
- receive impulses from other cells (many per cells)
Cell body
- aka soma, aka perikaryon
Rough ER
- also called nissel substance in nerves
- surround the nucleus
- making lots of diff proteins called neurotransmitters
- ribosomes = help transcribe and translate those proteins
Axon
- one per cell
- sends impulses away from neuron to axon terminal
Why do neurons need nutritional and structural support?
- neurons are long lived and don’t divide
- if we lose a neuron, we can’t make a new one
What is mainly astrocytes and oligodendrocytes and are relatively short lived and divide and replace all the time?
- neuroglia
- we make lots of these
What brain tumors arise from neuroglia and are not derived from neurons?
- meningiomas and glioblastomas
Chemical synapse
- neurotransmitters are released from axon terminal into synaptic cleft and bind to receptors on second neuron (or muscle or gland)
- form of exocytosis
Electrical synapse
- ions pass from one cell to another thru gap junctions
- charged particles create electricity
- they will go thru gap junctions and talk to second neuron
Myelin
- membranous sheath that covers axons
- increase speed of action potential propagation
- going to insulate axon
- not all axons are myelinated
Gray matter
- unmyelinated regions of CNS
- neuron cell bodies, dendrites, some neuroglia
- in brain called cortex
- superficial to white matter in the brain but deep to white matter in the spinal cord
White matter
- myelinated region of CNS
- axons and glia
- bundles of axons called “tracts” in CNS
Spinal cord
- functions: sensory and motor innervation of body 2-way conduction of signals btw body and brain
- major center for reflexes (don’t necessarily need a signal to go all the way up to the brain)
- reflex: Dr. Hammering your quadricep tendon and your knee kicks up
- location: from foramen magnum to level of 1st/2nd lumbar vertebra
Cerebrum
- sensory, motor, and association areas
- higher cognitive functions occur here -> memory
- thinks part of the brain
Cerebellum
- adjusts motor activities based on sensory information
- fine tune movement based on info we received
Diencephalon
- thalamus, hypothalamus
- sensory info relay, visceral control
Brain stem
- midbrain, pons, medulla oblongata
- relay center
- directs nerves where to go
What does the cerebrum have?
- divided in to left and right hemispheres
- has gyri (bumps) and sulci (grooves)
- divided into lobes named after overlying bone (frontal, parietal, temporal, occipital)
Longitudinal fissure
- separates right and left hemispheres
Central sulcus
- separates frontal and parietal lobes
Lateral sulcus
- sylvian fissure
- separates temporal lobe from frontal and parietal lobes
Major sensory areas
- primary sensory cortex: is in postcentral gyrus of parietal lobe (most of our sensory information)
- primary visual cortex: is in occipital lobe
- primary auditory cortex: is in temporal lobe (hearing sense)
- look at slide for pictures
Major motor areas
- primary motor cortex: precentral gyrus of frontal lobe
- Broca’s area: in left frontal lobe controls motor movements for speech
Major association areas
- wernicke’s area: in the left parietal and temporal lobes is involved with recognizing and comprehending language (written and spoken)
- association = meaning that you hear something from your auditory sense and then associate it w/ a meaning
Broca’s aphasia
- effects the ability to produce speech
Wernicke’s aphasia
- effects the ability to understand language
- can put tgthr words into a sentence but don’t mean anything
Classification of white matter in the brain
- association fibers: travel within a hemisphere
- comissural fibers: travel btw hemispheres
- projection fibers: travel from spinal cord to brain and vice versa
Corpus callosum
- a bundle of myelinated axons connecting right and left hemispheres
What does the cerebellum look like/do?
- has folia: lea-like folds that increase surface area
- white matter of cerebellum called arbor vitae
- function: maintains balance and posture by automatically adjusts motor activities based on sensory info
- controls motor activity
Thalamus
- involved sensory information relay and processing
- relay things from the spinal cord to the cerebral cortex or down the other way
Hypothalamus
- main visceral (organ) control center
(Emotions, autonomic functions, hormone production, body temperature, hunger/thirst, formation of memory)
Midbrain
- helps to process visual and auditory info
- maintains consciousness
Pons
- connects brain stem to cerebellum
- relays sensory information to cerebellum and thalamus
- subconscious somatic and visceral motor control (things you can control w/o thinking abt it)
Medulla oblongata
- connects brain to spinal cord
- relays sensory info to thalamus
- autonomic centers regulate visceral function
Meninges
- connective tissue membranes that surround the brain
Cerebrospinal fluid
- cushions the brain and provides immunologic protection
Blood-brain barrier
- formed by astrocytes protects brain from blood-borne toxins and pathogens
3 layers of connective tissue that covers the brain: Dural Mater
- double layer of defense CT. Dural venous sinuses inside. Periosteum (dark yellow) and Meningeal layers (light yellow)
3 layers of connective tissue that covers the brain: arachnoid mater
- deep to dura
- spidery mother
3 layers of connective tissue that covers the brain: Pia Mater
- delicate, adheres directly to surface of brain
- astrocytes help this layer of CT adhere directly to the brain
False cerebri
- separates right and left hemispheres
Falx cerebelli
- separates cerebrum from cerebellum
Dural venous sinuses
- drain venous blood from brain back to systemic circulation (internal jugular vein)
- systemic circulation: all the blood that’s pumping thru your body basically not relegated to a single organ
- in btw meningeal and periosteum layer of dura mater
- look at picture in slides
Ventricles of the Brain
- lateral ventricles (first and second) with cerebrum
- cerebral aqueduct: connects 3rd and 4th ventricles
- third ventricle within diencephalon
- fourth ventricle: btw pons and cerebellum
Flow of CSF
- CSF is produced by ependymal cells of the choroid plexus (“roof” of ventricles)
- Flows to subarachnoid space
- Absorbed into dural sinuses via arachnoid granulations (projections of arachnoid mater into dural sinus)
Hydrocephalus
- excess production or improper drainage of CSF
- extra fluid puts pressure on neural tissue
- placement of shunt to drain excess fluid