CLIPP 10 Flashcards

1
Q

adverse rxn w rotavirus vaccine

A

happens typically within first several days and most commonly with the first dose of it
-is a live virus vaccine, can cause fever

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2
Q

MMR and varicella adverse rxns

A

are live virus vaccines and can cause fever in some infants 7-10d after administration

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3
Q

FWS vs FUO

A

FWS - complete hx and Pex done and no identified source of fever
FUO - fever >38.3 (101) for at least 2 weeks with failure to reach dx after 1 week of eval

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4
Q

sepsis dx

A

typically requires +BC? card 6 case 10

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5
Q

occult bacteremia

A

applied to child with bacteremia who looks well or is a little fussy (compared to toxic or ill appearing child with bacteremia is more likely to be septic)

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6
Q

SBI - and most common cause

A

serious bacterial illness - kids with occult bacteremia will likely not get this while kids with sepsis are a medical emergency.
-most common cause is a UTI

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7
Q

organisms responsible for a lot of the occult bacteremia we see, if we see it

A

strep pneumo, hib, NM, salmonella enteritidis

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8
Q

a wbc count of <15000

A

excellent at ruling out bacteremia

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9
Q

will most young children presenting w/ fever w/o focus be bactremic?

A

no - thus empiric tx not always indicated

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10
Q

kernigs and brudzinski signs

A

kernig - flex at hip and knee, then extend at knee: positive result of pain w/ ext of knee
brudzinski - positive result is flexion of hip and knee in response to flexion of neck by examiner
*note that most kids under 1 yo will not demo a kerning or brudzinski sign even if they do have bacterial meningitis i.e. the absence of meningismus cannooottt rule meningitis out. but if theo do demo a + or both + sign, then do LP

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11
Q

one of the things on ddx of bulging fontanelle

A

meningitis

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12
Q

paroxsymal criyng is __ and could indicate __

A

for example, crying when picked up, meningitis

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13
Q

opisthotonos

A

hyperextension (severe) , almost in bridge form. In severe cases of meningitis, increased extensor tone of neck and spine leads to hyperextension of the entire spine or “opisthotonos.”

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14
Q

nuchal rigidity

A

involuntary reisstance to neck flexion

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15
Q

UTI presentation

A

commonly presents as fever and no focus on physical examination and a relatively unremarkable review of systems.
Fussiness and lack of appetite are common associated symptoms.

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16
Q

UTI gender and age RF

A

females =39 (102.2) or more than 24 h of FWS

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17
Q

in what case is a cxr in an immunized kid w/o resp sx indicated

A

if WBC>=20,000 x 10^3

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18
Q

how could young infants in sepsis present

A

hypothermia rather than fever

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19
Q

most common cause of bacterial meningitis in kids is

A

SP, NM (conjug pneumococcal vaccine only projects against 13 serotypes)

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20
Q

common culprit in viral meningitis and sx

A

enterovirus

in kids, presents w/ fever and can also have diarrhea, rash, or URI sx

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21
Q

roseola - age, virus type, sx, tx

A

Common viral illness in children under 2 years of age.
Caused by human herpes virus 6 (HHV-6).
A high fever is often the only symptom in the first few days of illness and typically lasts for 3 to 5 days.
Some patients develop a rash as the fever resolves; the rash can persist from 1 to 4 days.
Appropriate management for a child with roseola is to reassure the family that no other therapy is indicated

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22
Q

occult bacteremia vs sepsis

A

by definition, it may be found in a child with high fever with no other symptoms and no source of infection on physical examination who appears well (as opposed to children with sepsis who also have bacteria in their blood).

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23
Q

hsv gingivostomatitis

A

often in 10 month to 3 yo kids, starts as irritability and fever but then oral lesions / vesicles form around mouth

24
Q

PPV of red tM

A

essentially none.

25
Q

to dx OM, should see

A

poor mobility and bulging at least mildly - without either of these, hard to dx om

26
Q

viral uri sx

A

cough, coryza, conjuncitva, fever , rhinorrhea

27
Q

when to obtain cxr

A

if sx of lower resp tract dz or if wbc>=20k, or if ill appearing

28
Q

if kid has diarrhea, do these testing steps

A

stol guaicia and fecal leukocytes and if positive, get stool and blood cultures

29
Q

in what age group is acute rheumatic fever rare and implication of this?

A

kids less than 3yo - implication is no need to do rapid or strep culture in kids <2 yo

30
Q

which age group should not get strep rapid or culture

A

kids <2yo

31
Q

general rule in approaching if an LP is needed

A

General Rule

If you are going to treat any febrile, ill-appearing, young infant (especially an infant less than 3 months of age) with parenteral antibiotics that will cross the blood-brain barrier (ceftriaxone is probably the most commonly used antibiotic in this setting), an LP to rule out meningitis should be performed:

Parenteral antibiotics will affect the CSF culture results, and
The antibiotic treatment of bacterial meningitis requires higher doses.
On the other hand, if the infant is not toxic, or has another obvious focus of infection, a lumbar puncture may not be necessary.

32
Q

can bagged specimens be used for culture

A

no - high contamination rate

33
Q

interp of high wbc (22k) on cbc in terms of ddx

A

If Holly was a low-risk child (immunized and looked well), given the low prevalence of bacteremia in that setting the positive predictive value of WBC’s would be very low. Almost all patients with a positive WBC would be false positives.
It is a piece of the puzzle, however, and in the setting of a child with an increased likelihood of SBI (Holly appears ill) the elevated WBC and bands increase the likelihood of a SBI.

34
Q

+nitrites and +leuk est strongly suggests:

A

UTI

35
Q

when does +nitrite test occur and what is its sensitivity and specificity

A

gram- bacteria reduce nitrAte to nitrite thus nitrIte happen when these specific bacteria are present in the urine for 3-4h
*a positive nitrite is highly specific (few false positivties) but negative nitrite has poor sensitivity ( lots o false neg) esp in young infants who urinate a lot

36
Q

nitite producing bacteria especially incldue

A

protues, kleb, e coli

37
Q

+ leuk est

A

detects esterase from broken down leukocytes and indicates presence of WBC in urien but pyuria can be seen in things other than UTI

38
Q

can +leuk est dx a UTI?

A

not alone

39
Q

what is +pyuria defined as in cetringed vs uncentrofiuged urine

A

> 5 WBCs per high-power field (hpf) in a centrifuged urine considered positive. If a counting chamber is used, then > 10 WBCs per microliter in uncentrifuged urine is considered positive.

40
Q

route of UTI abx administration

A

most can be oral unless too sick to take PO, lack of compliance

41
Q

most common cause of UTI in kids not recently on abc

A

ecoli, then other gram- like proteus, kleb, or by enterococus

42
Q

good pyelo med

A

ampicillin/gent

43
Q

enteroccoi tx

A

amp

44
Q

ceftriaxone covers, does not cover, contraindic

A

most gram- bacilli EXCEPT pseudomonas, not enterococci, don’t give calcium thru same line otherwise it forms precipitates

45
Q

ceftriaxone does not cover , among other, these things…

A

pseudomonas, enteroccci

46
Q

pip tazo does and does not

A

gram - bacili and psuedomonas, less optimal for enterocci

47
Q

pip tazo vs ceftr

A

pip tazo and cent both do gram-bacili but ceft does NOT do psuedomas

48
Q

in whom is cipro approved and the exception to cipro tx

A

kids> 1 yo w complicated UTI resistant to other things, but quinolines in general not to be used w/ kids under 16. cipro exception is in CF Kids to tx their pseudomonas

49
Q

nitrofurantoin tx

A

cysitis not pyelo - and in fever + high wbc w +UA, consider pyelo as possibility.

50
Q

renal techniticum scan

A

used for providing evidence of pyelo but not needed in pt who responds well to abx/tx

51
Q

vcug

A

not routinely done after first febrile uti unless renal/bladder US demonstrate reflux - but IS done after 2nd febrile uti.

52
Q

f/u to do after 1st pyelo episode

A

US renal and bladder, gives info about collecting ducts and renal structure. can be done at completion of abx tx unless kid has severe case or not resolvign

53
Q

grading of VUR and implications

A

1-5, 5 is most severe. 1 and 2 tend to resolve spontaouelsy and grade 4-5 tend to need surgery. grade 3 might need surgery.
g1-2 can be followed by pcp but g3-5 need urolo referral

54
Q

reflux implication on further UA

A

do UA if pt is febrile illness w/o clearly defined focus.

55
Q

RF for recurrent UTI

A

VUR

56
Q

role of prophylactic abx in VUR

A

reduces UTI recurrence but no change in renal scaring

57
Q

most common bacterial illness in female infant

A

uti