Clinical Correlates

Question 1

Mannose residue of oligosaccharide is not phosphorylated, hence, the glycoprotein does not reach the lysosomes where its supposed to be degraded

Large inclusion bodies in cells

Answer 1

I cell disease

Question 2

Skeletal abnormalities
Restricted joint movement
Coarse facila features
Severe psychomotor impairment

Answer 2

I cell disease

Question 3

Occurs through interaction of ZP3, an O-linked glycoprotein in the zona pellucida, with a surface protein on the sperm surface, possibly galactosyl transferase

Answer 3

Fertilization

Question 4

Circulating leukocytes adhere to the endothelium through selectins on the latter’s cell surface

Answer 4

Inflammation

Question 5

Contains neuraminidase, glycoprotein that allows new viruses to exit infected cells

Answer 5

Influenza virus

Question 6

HIV surface glycoprotein

Attachment

Answer 6

gp120

Question 7

Surface glycoprotein of HIV

Fusion withe the host cell membrane

Answer 7

gp41

Question 8

Glycosphingolipid in blood type

A

Answer 8

N acetylgalactosamine

Question 9

Glycosphingolipid in blood type

B

Answer 9

Galactose

Question 10

Glycosphingolipid in blood type

AB

Answer 10

N galactosamine and galactose

Question 11

Glycosphingolipid in blood type

O

Answer 11

None

Question 12

Eicosanoid

Inhibits phospholipase A2

Answer 12

Steroids

Question 13

Eicosanoid

Irreversible inhibition of COX

Answer 13

Aspirin

Question 14

Eicosanoid

Reversible inhibition of COX

Answer 14

NSAIDS

Question 15

Eicosanoid

Competitive inhibitor of lipoxygenase

Answer 15

Zileuton

Question 16

Eicosanoid

Leukotriene-receptor blockers (competitive receptor antagonist)

Answer 16

Zafirlukast

Montelukast