Alcohol Metabolism Flashcards

1
Q

The metab of ethanol results in massive increase in the concentration of cytosolic____ in the liver

A

NADH

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2
Q

Ethanol —-> ______

A

Acetaldehyde

By enzyme alcohol dehydrogenase

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3
Q

Acetaldehyde —-> _______

A

Acetate
By enzyme aldehyde dehydrogenase
Inhibited by disulfiram

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4
Q

Enzyme inhibited by disulfiram

A

Acetaldehyde dh

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5
Q

Accumulation of this leads to flushingm tacycardia,hyperventilation and nausea

A

Acetaldehyde

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6
Q

Alternate pathway for ethanol metab induced in chronic alcoholics

A

Micrisomal ethanol oxidation system

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7
Q

Site of microsomal ethanol oxidation

A

SER, requires CYP2E1 from CYP450

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8
Q

High NADH in alcohol metab favor hypoglycemia by stimulating these conversions (2)

A

Pyruvate—-> lactate

OAA—-> malate

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9
Q

Explains ketoacidosis in alcohol metab

A

Dec OAA (since diverted sya to malate), so acetyl coa is diverted to ketone body synthesis in liver

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10
Q

Reason for thiamine def in alocholic

A

Thiamine absorption is inhibted by alcohol

Poor diet

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11
Q

Increase/
Dec in chronic alcohol consumption

Fatty acid oxidation
NAD/NADH ratio
Lipogenesis
Fatty acid availabity
Glyceraldehyde3 phosphate availabity
A
Decrease
Dcrease
Inc
Inc
Inc
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12
Q

Smooth philtrum, thin smooth vernillion border of the upper lip
Short palpebralfissures
Short upturned nose
Microcephaly

A

Fetal alcohol syndrome

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