Class. of microorganisms Patho Flashcards
What is an example of a strain ?
Escherichia coli O157:H7
Escherichia coli O157:H7 gram stain ?
Gram neg. rod
Escherichia coli O157:H7 found in?
Guts in animals
Main reservoir: cattle
Escherichia coli O157:H7 causes
Foodborne illness
Hemo Uremic syndrome
Escherichia coli O157:H7 transmission
Fecal-oral route
Escherichia coli O157:H7 pathogenesis
-ingested >stomach
- acid-resistant
- colonizes intestines ( attaches to microvilli of intestinal cells )
Releases shigalike toxin
( disrupts protein syenthesis in intestinal cells>cell death )
Escherichia coli foodborne illness sign
Severe abd. Cramps
Blody diarrhea
Vomitting
Escherichia coli foodborne dx
Stool culture
Escherichia coli tx
Supportive
-no antibiotics
Escherichia coli & Hemolytic uremic syndrom
- sigalike toxin crosses from intestine into bloodstream
- shigalike toxin binds to red blood cells > destruction of RBCs
- Damaged RBCs reach kidneys and clog filtering system
Hemolytic Uremic Syndrome signs
Anemia
Low platlet count
Kidney failure
Hemolytic uremic syndrome dx
Blood tests
Stool culture
Hemolytic uremic syndrome tx
Rbc/ platelet infusions
Dialysis
Influenza Virus causes
Flu
Influenza virus season
December - march
Influenza virus RNA virus
8 segments of rna
Influenza viral protein (H)
Hemagglutinin; binds to sialic acid on host cells
Influenza viral proteins (N) :
Neuraminidase ; helps virus exit cell
Influenza A infects
Humans & animals
Infleunza A divides
Into strains based on H and N
18 different H proteins
11different N proteins
Influenza B infects
Humans only
Influenza C infects
Kids, huamns and pigs
Infulenza D infects
Cattle
Influenza transmission
Droplet
Fomites
Occur before symtpoms
Infleunza Pathogensis
- Hemagglutinin binds to sialic acid receptors on epithelial cells if respiratory tract
- influenza virus reolicates inside repirstory epithelial cells
- influenza virus is released from cell and spreads other respiratory eoithelial cells a
Influenza Dx
Nucleic acid identification
Influenza tx:
Supportive, antivirals available by Rx
Infleunza Prevetion
Hand washing
Flu shot