Class #6 - Infection (part 2) - Herpes

Question 1

Known types? affecting human?

Answer 1

9 only 8

Question 2

Genom?

Answer 2

double standed DNA

Question 3

Virus recognize cell by?

Answer 3

recognize cell-surface proteoglycans (heparan sulfate) with glycop+ gB and gG of HSV

Question 4

Herpes viruses causes in cell?

Answer 4

cell lysis

Question 5

Special property?

Answer 5

Latency+reactivation

Question 6

Virus targeting neurons?

Answer 6

Neurotropic: HSV-1, HSV-2 and varicella-zoster

Question 7

Virus targeting leukocytes?

Answer 7

Blood-born: CMV, EBV, human herpes virus 6-7-8

Question 8

Human herpes virus 1?

Answer 8

Herpes simplex type 1

Question 9

Herpes simplex type 1 what it does?

Answer 9

enter skin, stay in trigeminal ganglion
reactivation: 9mm/hours
Lesions: cold sores due to cell lysis, stays in region of sensory ending because Tcells kill infected skin cells

Question 10

Whitlow?

Answer 10

HSV on fingers

Question 11

Human herpes virus 2?

Answer 11

HSV-2: Similar to HSV-1, but genital area

Question 12

Major immune defense against HSV?

Answer 12

Cell mediated

Question 13

HSV drugs?

Answer 13

Acyclovir: Inhibits DNA polymerase

Question 14

Human herpes virus 3?

Answer 14

Varicella-Zoster: 
First exposure: Chicken pox (varicella)
2nd exposure: Shingles (zoster)
Transmission: Can enter lungs/skin
Virus targets?: Skin/mucous membrane
Latency: Dorsal root sensory ganglia

Question 15

Human herpes virus 4?

Answer 15

Epstein-Barr Virus (EBV): Causes mononucleosis
Affects: Epi. cell in the pharynx and b cells
Latency: In B cells and epi cells.

Question 16

Human herpes virus 5?

Answer 16

Cytomegalovirus (CMV): Usually ASx

Issue: Immunosuppressed and newborn: cognitive deficits, hearing loos, …

Question 17

Human herpes virus 6/7?

Answer 17

Roseola virus:
Secreted in saliva
Rash + mild fever in infancy

Question 18

Human herpes virus 8?

Answer 18

Kaposi’s Sarcoma: Can cause cancer in immunosuppresed (HIV+)