Circulatory Disorders Flashcards

1
Q

What is arteriosclerosis?

A

general term used to described many several conditions - wall of arteries thicken and lose elastic properties (become harder)

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2
Q

What is atherosclerosis?

A

condition where plaque builds up inside of artery walls - causing narrowing due to this build up
- where blood flow decreases and blood pressure increases

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3
Q

What can atherosclerosis lead to?

A
  • depending on where plaque is, can lead to chest pain, blood clots, shortness of breath, heart attack or heart failure
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4
Q

How is arteriosclerosis treated?

A
  • using angioplasty: a procedure where a tube is inserted into a clogged artery, the tube reaches the site where the artery is clogged, tiny balloons is inflated to force artery open –> where a vascular sent tube is inserted into blocked area, vessels open
  • Aspiration: a medication that prevent platelets from sticking and reduce clots
  • Urokinase and t-PA: special clot-busting meds that are used to breeze down clots and improve blood flow
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5
Q

Another way arteriosclerosis is treated?

A

Coronary Bypass
- surgeons choose to re-route the flow blood rather than try unblock blood vessels
- section of healthy artery or vein from another part of body like legs and use to create new pathway for blood around blockage
- may be double, triple, or quadruple bypass - depending on number of blockage

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6
Q

What is an aneurysm?

A
  • damaging the artery walls
    Definition: a bulge in an artery due to a weakened area of arterial wall
  • b.p cause aneurysm to grow larger in time -> increasing risk of bursting –> if it does their internal bleeding lead to death
  • most occur in aorta
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7
Q

How are aneurysms treated?

A

treated by surgery that remove damaged portion of blood vessel and replace it with a patch or a graft

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8
Q

What are heart valve diseases

A
  • Where valves does not close completely and blood flows backward instead of forward → this is called regurgitation
  • Other cases, valves opening become narrowed from thickening or scarring, pressuring blood flow out of ventricle/atria → stenosis
  • Common form = mitral valve prolapse, one or both mitral valve flaps bulges back into atriums, preventing valve from forming a tight seal
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9
Q

Causes of heart valve diseases?

A
  • Natural process of aging, damage from infection or heart attack, or connective tissue disorders
  • Some regurgitation and stenosis occur at the same time → affect more than 1 valve → reduce hearts ability to pump blood through body → common cause: heart failure
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10
Q

Treatment of heart valve diseases?

A
  • Repair valves or replace them
  • Replacement: may use animal or human sources or made of metal, plastic, or other material
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11
Q

What is arrhythmia?

A
  • problem with speed or rhythm of heartbeat
  • Irregular heartbeat may be harmless, but in some cases can lead to insufficient blood flow to brain or other organs
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12
Q

How is arrhythmia treated?

A

medication or may need a pacemaker (sends electrical impulses that control heart rate)

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13
Q

How does pacemakers work?

A

-Attached to skin of chest and includes a sensor that monitors heart
-Only transmits electrical impulses to heart when heartbeat is abnormal → can send to atria, ventricles, or both depending on issue

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14
Q

What is a congenital heart defect?

A
  • Defect in the heart → present at birth
  • Problems in walls dividing the chambers of heart in valves and structure of blood vessels near heart
  • These defects can be heard (heart murmurs) with a stethoscopes (but has limitations, need more tests to get a full diagnosis), where blood leaks through valves can be heard → some defects can arise later in life (these are called acquired heart defects)
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15
Q

Treatment of congenital heart defects?

A
  • Can remove or reduce damage
  • CT scan or MRI scan can be used to create an exact plastic or wax model of body part like heart → allowing surgeons to plan and practice surgery beforehand
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16
Q

What is a stroke?

A

When arteries supplying blood to brain are damaged → cut flow of oxygen and nutrients to blood tissues

17
Q

What is ischemic stroke?

A

when a clot in a blood vessel blocks the flow of blood to the brain

18
Q

What is a hemorrhagic stroke?

A
  • when a blood vessel in the brain bursts and blood flows into the surrounding brain tissue
  • Both kill brain cells and can lead to permanent damage
19
Q

What is the treatments of strokes?

A
  • must start within few hours of symptoms
    3 main treatments
    1. Drugs - clot busters
    2. Surgery
    3. Non-surgical procedure
  • All depend on how serious stroke is, age, and general health of patient, and how soon treatment is started
20
Q

How are circulatory system disorders diagnosed?

A
  1. Coronary angiography
  2. ECHO
  3. Electrocardiogram
  4. Heart monitors
  5. Cardiac catheterization
21
Q

What is a coronary angiography?

A
  • Mapping the coronary arteries → done by injecting liquid dye into artery and then take X ray as dye moves through blood vessels
  • Doctors can determine where the circulation is blocked
22
Q

What is an ECHO?

A

-Uses ultrasound tech to create picture of heart
-Records sound waves to reveal shape and movement of heart valves, the size of heart chambers, and how well heart functions
-May be done to determine cause of stroke or risk of blood clots

23
Q

What is electrocardiogram?

A
  • Cardiac stress test
  • Measures hearts electrical activity, blood pressures, and heart rate while person exercises → determines hearts response to stress of exercise
  • Helps determine cause of unexplained chest pain or if person is experiencing irregular heartbeats, excessive dizziness, or fatigue
24
Q

What is a heart monitor?

A

Holter monitor:
- Used when disturbances in heart rhythm are detected and patients are given this recording device to wear for 24-48 h
- Attaches to chest via small electrodes
- Device records heart rhythm and produces a diagnostic pattern
Event monitor:
- Smaller device that patients activates when symptoms occur
- Allowing to record reading

25
Q

What is a cardiac catheterization?

A
  • Used in conjunction with other tests like angiography
  • A thin flexible tube (catheter) is inserted through artery in groin or arm that is guided through body until tip reaches the heart
  • X rays are taken of heart and blood vessels → dye is often injected in catheter
26
Q

What is hemophilia?

A
  • Command blood disorder with is inherited, life-threatening condition
  • Bleed for a long time and are risk of dying from internal bleeding from minor injury
  • This is a sex-linked trait in humans, a rare disorder that usually in males
27
Q

What causes hemophilia?

A

insufficient clotting proteins in blood

28
Q

What are treatments of hemophilia?

A

missing clotting proteins in blood (called factor VIII) and some hemophiliacs can be treated with injections with this protein

29
Q

What is anemia?

A

Blood contains fewer than normal health red blood cells. Causing dizziness, fatigue, shortness of breath, headache, and cold hands and feet

30
Q

What are the types of anemia?

A

mild, short-term, chronic or sever (can be life threatening as lack of O2 in blood can damage brain, heart, and other, can cause death)

31
Q

What is the cause of anemia?

A

Blood loss and when red blood cells do not contain enough hemoglobin

32
Q

What is the treatment of anemia?

A

For mild and short-term: treated with dietary supplements

33
Q

What is leukemia?

A

Cancer of white blood cells
2 main types -
1. Mueloid - characterized by presence of too many white blood cells that are immature and unable to fight infections, crowding out red blood cells, causing anemia
2. Lymphoid - Cancer of lymphocytes, Symptoms are similar
- Occur in acute or chronic
- Acute: appear suddenly and death quickly
- Chronic: may go undetected for months/years

34
Q

Treatment of leukemia?

A
  • Blood transfusion in increase red blood cells and healthy white blood cells
  • Chemotherapy
  • Bone marrow transplant → provide health narrow and healthy white blood cell can grow
35
Q

What are the solutions for shortage of organ transplant

A

Xenotransplant
- Some animal tissue have been used as grafts to humans → however these are chemically treated and not living functional tissue
- Heart valves from pigs have been successfully transplanted into humans
- However there are many health, safety, legal, etc issues to consider
- Potential problems:
a) Risk of transmitting diseases
b) Risk of immune system rejecting tissues

Artificial Hearts
- Faulty human hearts have already been replaced with complete artificial, self-contained, mechanical pumps
- Made of titanium and plastic
- Core mechanism is a hydraulic pump that pump more than 10 L of blood/minute
- Powered by batteries, one is external, worn in a belt pack around persons waste → transmits power by wireless energy transfer across skin to rechargeable battery inside abdomen
- Allow person to disconnect external battery to perform activities (showering)
- Internal battery runs heart → electronic controller implanted in abdominal wall monitors and controls pump speed of heart

36
Q

What is the use of nanotech?

A
  • Help diagnose cardiovascular and other disease more quickly and accurately
  • Involves microscopic structures (a tiny fraction of width of human hair) -> detect changes in cells and molecules, many diseases produce changes in quality or type or protein molecules before obvious symptoms
  • Molecules that point out the development of disease are called biomarkers
  • NANOTECH can give biomarker readings and help diagnose within 30 mins
  • Lead to earlier detection, more individualized patient care, and reduced costs
37
Q

What is chemotherapy?

A

Use of drugs that kill cancer cells
- Disadvantage = same drugs kill healthy cells and produce unpleasant side side effects
Cancer cell produce different enzymes than healthy cells surround it
- Scientists are also testing microscopic containers drugs, made of biodegradable gels, that can be injected into body → release only when encounter cells produce enzymes
- Prototype of nanovalve = design release drugs only to cells that have a basic pH (healthy tissue differs slightly from diseased tissue)
- In chemical environmental that is at neutral to acidic pH (nono valve remains closed) → opens to release drugs when body’s internal environmental is a basic pH