Ciclo de Krebs Flashcards

1
Q

en dónde ocurre el Ciclo de Krebs?

A

mitocondria de todas las células menos eritrocitos

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2
Q

Sustrato

A

AcetilCoA (2 moléculas)

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3
Q

Productos intermediarios

A

citrato
acetoglutarato-produce otros AAs
succinilCoA-síntesis de porfirinas
oxalacetato-produce ATP, Glucosa

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4
Q

enzimas !!!

A

citratosintasa- une Acetilcoa con oxalacetato
isocitratodeshidrogenasa
acetoglutaratodeshidrogenasa

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5
Q

Ciclo de Krebs es catabólico o anabólico?

A

anfibólica

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6
Q

Mineral/cofactor

A

Calcio-Ca2–>mineral de regulación alostérica
Si se eleva el Ca2-se activan enzimas catabólicas

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7
Q

paso 1

A

ACETILCOA-citratosintetasa-CoA—CITRATO

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8
Q

carga energética

A

10 ATPs por molécula de AcetilCoA

3 NADH=7.5 ATPs
1 FADH2=1.5ATPs
1GTP= 1ATP

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9
Q

Paso 1,3 y 4

A

son los + !!! y son irreversibles

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10
Q

el Calcio activa o inhibe las 3 enzimas?

A

activa

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11
Q

si sube el GTP, el NADH, FADH2 qué pasa?

A

Se inhibe el Ciclo de Krebs

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12
Q

Carga energética del acetoglutarato

A

1 NADH

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13
Q

Carga energética del succinil CoA

A

1 NADH

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14
Q

Carga energética del oxalacetato

A

1 NADH
1 FADH2
1 GTP

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15
Q

Qué significa que suba el Calcio intracelular?

A

que falta energía
Se activan las 3 enzimas(citratosintasa, isocitrato deshidrogenasa, acetoglutaratodeshidrogenasa)

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16
Q

Una función es…

A

convertir malato a espartato
malato lo saco de la mitocondria