Chs 11, 12, 13 (Heme) Flashcards
Progenitor cells, or parent cells, for myelopoiesis and lymphopoiesis are derived from which of the following?
a. Pluripotent stem cells
b. Unipotent stem cells
c. Multipotential progenitor cells
d. Myeloproliferative cells
a. Pluripotent stem cells
What is the name of the region of the lymph nodes that contain most of the T cells?
a. The primary follicles
b. The paracortex
c. The secondary follicles
d. The primary cortex
b. The paracortex
Kostmann syndrome is a severe congenital neutropenia. Which of the following is characteristic of this condition?
a. Bone marrow disorders
b. Severe viral infections
c. Autoimmune disorders
d. Severe bacterial infections
d. Severe bacterial infections
Drug-induced neutropenia is a disease that has significantly increased in incidence over the last several decades. What is the attributing factor in the increased incidence of drug-induced neutropenia?
a. Treatment of cancer by chemotherapeutic drugs
b. The decrease in the use of street drugs
c. The destruction of tissue cells by cocaine
d. The new drugs developed to treat autoimmune diseases
a. Treatment of cancer by chemotherapeutic drugs
Infectious mononucleosis is a lymphoproliferative disorder caused by the EBV that is usually self-limiting and nonlethal. Which of the following complications can arise during this mostly benign disease?
a. Peripheral nerve palsies
b. Rupture of the spleen
c. Rupture of the lymph nodes
d. Severe bacterial infections
b. Rupture of the spleen
You are presenting an educational event to a group of cancer patients. What would you cite as the most commonly occurring hematologic cancer?
a. Acute lymphocytic leukemia
b. Hodgkin lymphomas
c. Non-Hodgkin lymphomas
d. Mantle cell lymphoma
c. Non-Hodgkin lymphomas
Endemic Burkitt lymphoma occurs in regions of Africa where what other infections are common?
a. Herpes zoster and Epstein Barr
b. Herpes zoster and streptococcal
c. Malaria and streptococcal
d. Epstein Barr and malaria
d. Epstein Barr and malaria
ALL and AML are two distinct disorders with similar presenting clinical features. What clinical feature do ALL and AML share?
a. Night sweats
b. Weight gain
c. High fever
d. Polycythemia
a. Night sweats
Definitive diagnosis of multiple myeloma includes the triad of bone marrow plasmacytosis, lytic bone legions, and what?
a. Oligoclonal bands in the CSF
b. Bence-Jones proteins in the urine
c. Serum M-protein depression
d. BCR-ABL fusion protein in serum
b. Bence-Jones proteins in the urine
CLL commonly causes hypogammaglobulinemia. This makes clients with CLL more susceptible to infection. What are the most common infectious organisms that attack clients with CLL?
a. Acne rosacea
b. Pseudomonas aeruginosa
c. Staphylococcus aureus
d. Escherichia coli
c. Staphylococcus aureus
Large granular lymphocytes, or natural killer cells, have the ability to _______ target cells.
lyse
Which lymphatic tissue is associated with mucous membranes and called mucus-associated lymphatic tissue, or MALT? (Mark all that apply.)
a. Genitourinary systems and central nervous system
b. Respiratory passages and cardiovascular system
c. Alimentary canal and genitourinary systems
d. Cardiovascular system central nervous system
c. Alimentary canal and genitourinary systems
You are speaking to a group of genetic students touring your hospital’s laboratory. You talk about the possibility of a genetic predisposition for the leukemias being suggested because of the increased incidence of the disease among a number of congenital disorders. Which congenital disorders are these? (Mark all that apply.)
a. Cushing syndrome
b. Neurofibromatosis
c. Fanconi anemia
d. Down syndrome
e. Prader-Willi syndrome
b, c, d (Neurofibromatosis, Fanconi anemia, Down syndrome)
Tumor lysis syndrome, the massive necrosis of malignant cells that can occur during the initial phase of treatment of ALL, can lead to metabolic disorders that are life-threatening. Which metabolic disorders can occur because of tumor lysis syndrome? (Mark all that apply.)
a. Hyperuricemia
b. Hypokalemia
c. Acidosis
d. Alkalosis
e. Hypocalcemia
a, c, e (Hyperuricemia, acidosis, hypocalcemia)
Secondary malignancies in survivors of Hodgkin lymphoma have been attributed mainly to _____ therapy.
radiaion
