chronic inflammation 2

Question 1

What is granulomatous inflammation always characterised by?

Answer 1

Granulomas in tissues

Question 2

how are granulomas formed/what are they?

Answer 2

combination/aggregate of epithiloid macrophages in tissue

Question 3

How is Granulomatous inflammation stimulated/formed?

Answer 3

response to indigestible antigen

Question 4

what are epithiloid?

Answer 4

looks like epithelial

Question 5

what are granulomas surrounded by and what do they surround?

Answer 5

surrounded by lymphocytes

they surround giant cells

Question 6

What cell do granulomas contain?

Answer 6

eosinophils , neutrophils,

Question 7

what do giant cells consist of ?

Answer 7

several distinct cells - mainly macrophages

Question 8

describe the structure of a giant cell

Answer 8

large cytoplsm and multiple nuclei

Question 9

Are there always granuloma for giant cells to be present?

Answer 9

no

Question 10

name a type of giant cell other than macrophages

Answer 10

Langhans type

Question 11

where are Langhans type giant cells found?

Answer 11

TB tuberculosis

Question 12

describe structure of langhans type

Answer 12

large eosoniphilic cytoplasm
peripheral rim of nuclei

Question 13

what is surgical wound healing? primary or secondary healing intention?

Answer 13

healing by primary intention

Question 13

What type of giant cell might you see with a ruptured silicone implant? e.g breast implant

Answer 13

silicone associated giant cells

Question 14

what are the goals of surgical wound healing?

Answer 14

Minimal gap, small amount of granulation tissue, small linear scar

Question 15

what is healing of larger defects?

Answer 15

healing by secondary intention

Question 16

Describe the granulation tissue in growth in larger defects

Answer 16

lots of it

contraction & scarring

Question 17

describe Caseous necrosis

Answer 17

cell death in which the tissue has a cheese-like appearance
most common in TB

Question 17

what is the effect on angiogensis on thrombus

Answer 17

grows vessels through the thrombus

Question 18

how is tuberculosis formed

Answer 18

granulmoas in ur lungs

Question 19

what is sarcoidosis

Answer 19

development of granuloams within organs of the body

Question 20

state diseases in which a specifc cause of granuloama formation in unknown (e.g of non-inefective granulomas)

Answer 20

-Sarcoidosis disease (granulomas develop within body organs)

-Crohns disease ; chronic inflammatory bowels disease

-rheumotoid disease; autoimmune disease

Question 21

Name some Infectious granulomatous diseases

Answer 21

Tuberculosis (Mycobacterium tuberculosis),

Leprosy Mycobacterium leprae

syphilis