chronic inflammation 2 Flashcards
What is granulomatous inflammation always characterised by?
Granulomas in tissues
how are granulomas formed/what are they?
combination/aggregate of epithiloid macrophages in tissue
How is Granulomatous inflammation stimulated/formed?
response to indigestible antigen
what are epithiloid?
looks like epithelial
what are granulomas surrounded by and what do they surround?
surrounded by lymphocytes
they surround giant cells
What cell do granulomas contain?
eosinophils , neutrophils,
what do giant cells consist of ?
several distinct cells - mainly macrophages
describe the structure of a giant cell
large cytoplsm and multiple nuclei
Are there always granuloma for giant cells to be present?
no
name a type of giant cell other than macrophages
Langhans type
where are Langhans type giant cells found?
TB tuberculosis
describe structure of langhans type
large eosoniphilic cytoplasm
peripheral rim of nuclei
what is surgical wound healing? primary or secondary healing intention?
healing by primary intention
What type of giant cell might you see with a ruptured silicone implant? e.g breast implant
silicone associated giant cells
what are the goals of surgical wound healing?
Minimal gap, small amount of granulation tissue, small linear scar
what is healing of larger defects?
healing by secondary intention
Describe the granulation tissue in growth in larger defects
lots of it
contraction & scarring
describe Caseous necrosis
cell death in which the tissue has a cheese-like appearance
most common in TB
what is the effect on angiogensis on thrombus
grows vessels through the thrombus
how is tuberculosis formed
granulmoas in ur lungs
what is sarcoidosis
development of granuloams within organs of the body
state diseases in which a specifc cause of granuloama formation in unknown (e.g of non-inefective granulomas)
-Sarcoidosis disease (granulomas develop within body organs)
-Crohns disease ; chronic inflammatory bowels disease
-rheumotoid disease; autoimmune disease
Name some Infectious granulomatous diseases
Tuberculosis (Mycobacterium tuberculosis),
Leprosy Mycobacterium leprae
syphilis
