chronic inflammation 1 Flashcards
state 3 cells involved in chronic inflammation
lymphocytes
macrophages
plasma cells
does the effect of chronic inflammation tend to be long term or short term
long term
state 2 ways in which chronic inflammation may arise
-from acute inflammation
-arise from a primary lesion
what role does angiogenesis play in chronic inflammation
allows blood to enter damaged tissue
what substance stimulates angiogenesis to occur in chronic inflmmation
VEGF - Vascular Endothelial Growth Factor
what protein helps aid granulation mechanism when damaged tissue needs to be replaced (angiogenesis aiding tissue defects)
collagen
identify the 4 key processes involved in wound healing
1) Acute inflammation
2) Formation of granulation tissue
3) Angiogenesis
4) Fibrosis and scar formation
what is autoimmune disease?
when the body accidentally attacks normal cells (instead of foreign ones)
what are the 5 causes of chronic inflammation
-autoimmune disease
-granulomatous inflammation
-endogenous substances
-exogenous substance
-hydrophobic things
what is granuloma?
combination of epitheloid macrophages in tissue
state 3 cells in which granuloma’s contain
giant cells( sometimes) neutrophils, eosinophils
what type of hypersensitivity is granuloma part of
IV hypersensitiviity
Identify whether surgical wound healing and healing of larger defects are referred to as healing by primary or secondary intention respectively.
surgical wound healing - healing by primary intention
healing larger defects- secondary intention
during the wound healing process which cell organizes collagen to replace damaged tissue?
myofibroblasts
state the difference between wound healing and fracture healing?
wound healing- contains fibroblasts
fracture healing - contains fibroblasts and osteoblasts
