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BI442—Immunology > Chp 9-10—Exam 4 > Flashcards

Chp 9-10—Exam 4 Flashcards

1
Q

Which of the following is not a differences between naïve B cells and plasma cells?

A

plasma cells can be induced to undergo somatic hypermutation, but naive cells cannot.

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2
Q

Diphtheria and tetanus antibodies work by

A

neutralizing receptor binding fragments.

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3
Q

T/f

The epithelial cells of the mucosa respond to extracellular pathogens through the endosomal response system but are unable to detect pathogens or their antigens in the cytosol.

A

false

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4
Q

T/F

IgM, but not IgA will lead to complement fixation in the lumen of the intestine.

A

false

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5
Q

Whereas —— is the predominant immunoglobulin in intestinal fluid, —— is the dominant immunoglobulin in the urogenital tract.

A

dimeric IgA; pentameric IgM

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6
Q

activation of naive B cells begins with…

A

cross linking from multiple antigens

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7
Q

without T cells, —– can promote some IgM production in B1 cells

A

densely packed antigen

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8
Q

response seen in Digeorge patients without thymus

A

production of IgM in response to densely packed antigen

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9
Q

TFH cognate pair begins B cell transformation into…
making…

A

lymphoblast
soluble IgM

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10
Q

2 pathways for lymphoblast

A

primary or secondary focus

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11
Q

primary focus

A

cognate pair moves toward medulla and reproduce

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12
Q

—– focus makes plasma cells

—- focus makes memory cells

A

primary

secondary

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13
Q

results in germinal center

A

secondary focus

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14
Q

2 types of cells and zones in germinal center

A

centroblasts – dark zone – dedicated to making Ab

centrocytes – light zone – wait to bind antigen with TFH

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15
Q

within ——, germinal center drives immune response

A

a week

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16
Q

plasma cells are only long lived if…

A

they return to the bone marrow

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17
Q

can activate oncogenes

A

somatic hypermutation

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18
Q

—- deficiency prevents germinal centers from forming

A

CD40

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19
Q

isotype switching to —- is the norm for memory cells

A

IgG

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20
Q

mobile eosinophils destroy pathogen by…

A

cumulative action

21
Q

crossaffinity

A

eosinophil reaction to innocuous substances

22
Q

binary toxins

A

toxin component and binding component

23
Q

toxin fragments

A

toxoid

24
Q

pentameric IgM takes —- form on cell surface

A

IgM

25
Q

C1q has —- Fc binding domains

A

3

26
Q

best at complement activation

A

IgM and IgG3

27
Q

not able to fix complement

A

IgD

28
Q

deficiency that cannot allow complexes to be cleared

A

C1, C2, C3, C4

29
Q

leads to cyclical binding and release until pathogen is engulfed

A

y dimer signalling

30
Q

70% weight of mucin

A

glycosylation

31
Q

mucin sugars are —–

A

hygroscopic

32
Q

Gi commensals produce….

A

menadione and vit K

33
Q

compartment with dendritic cells and lymphocytes

A

inductive compartment

34
Q

effector compartment

A

lamina propria

35
Q

B cell area ONLY

A

isolated follicles

36
Q

mucosal proactive immunity

A

“inviting” pathogens via endocytosis into lamina propria allows immune response to be limited to that area, while creating B and T cells appropriate to attack that pathogen

37
Q

innate epithelial immunity allows…

A

limitation of inflammation

38
Q

intestinal macrophages arrive to lamina as…

A

monocytes

39
Q

intestinal macrophages uniqueness

A

Do not express receptors for IgA, IgG, complement, or IL-2
No chemotaxis, respiratory burst, cytokine production, or costimulation
No B7

40
Q

monitoring of gut commensals leads to…

A

large IgA repertoire

41
Q

survives endocytosis and causes tissue damage leading to bloody diarrhea

A

Shigella

42
Q

infects Peyer’s patches

A

polio

43
Q

vitamin produced by dendritics

A

A

44
Q

specialized CD8 cell - has granulytic activity - may be 𝛼:β or 𝛄:𝛅 type - limited in their antigen repertoire - bind through 𝛼E:β7 to E-cadherin

A

intraepithelial CD8

45
Q

specialized CD8 cell - has granulytic activity - may be 𝛼:β or 𝛄:𝛅 type - limited in their antigen repertoire - bind through 𝛼E:β7 to E-cadherin

A

intraepithelial CD8

46
Q

Penatmeric IgM is carried to gut lumen by —– receptor on stem cells in crypts

A

PIgR

47
Q

In respiratory and urogenital tract, B cells switch to —- - transported to mucosa by —–

A

IgG
FcRn

48
Q

antigen protein B is neutralized - normally binds GMI

A

Vibrio

BI442—Immunology (8 decks)

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