Chp 14 Diabetes Flashcards
As of 2015 - percent of the US with DM
9.4%
2012 - US DM costs total
Direct
Indirect
$245 billion
$176 B direct
$69 B indirect
5 counter regulatory hormones to insulin
1) glucagon
2) epinephrine
3) norepinephrine
4) growth hormone
5) cortisol
Elevated depressive sx and/or depression affect how many pts?
1 in 4
Diabetes distress
emotional issues related to worries and burdens living with chronic disease – in the ABSENCE of depression
Hyperglycemia sx
Increased thirst, excessive urination, unusual fatigue, unexplained hunger, rapid weight loss, slow healing cuts and infections
What % of people have T1DM
5-10%
What % loss of body weight can reverse insulin resistance?
5-7%
Insulin resistance, 3 factors
1) overweight/obesity
2) physical inactivity
3) poor diet
WHR increased = 2.5x risk
Pre-diabetes defn
Where does it occur primarily, i.e. tissue
What percent Americans with it?
A state of relative insulin resistance
Muscle - limited capacity to store CHO
38%
DX criteria for DM - A1c, fasting glucose, oral GTT
Pre-diabetes A1c criteria
6.5% or higher
>126 mg/dL
2 hour value >/equal to 200
Pre-DM: 5.7-6.4%
Fasting glucose normal
Pre-DM levels
70-99 mg/dL
Pre-DM: 100-125 mg/dL
GTT pre-DM values, 2 hour post prandial
140-199 mg/dL
US Preventive Services Task Force recs for screening glucose (age related)
As part of a CV risk assessment, ages 50-70, AND overweight/obese
What tissues do DM meds target?
pancreas - increase insulin release
liver - decrease glucose output
muscles - more responsive to insulin
gut - slow down absorption of CHO and glucose
kidneys - releasing excess glucose in urine