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pharma final > Cholinergic presynaptic modifiers > Flashcards

Cholinergic presynaptic modifiers Flashcards

1
Q

Acetylcholine synthesis

A

Acetyl-CoA + choline → Acetylcholine via Choline Acetyltransferase (ChAT)

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2
Q

Presynaptic inhibitors

A

Hemicholinium

Vesamicol

Botulinum toxin

Latrotoxins

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3
Q

Hemicholinium

A

inhibits choline uptake presynaptically

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4
Q

Vesamicol

A

Inhibits VMAT

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5
Q

Botulinum toxins

A

Cleave SNAREs and SNAPs, inhibits release

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6
Q

Latrotoxins

A

Increase presynaptic release, spider toxins.

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7
Q

Ganglion blockers

A

Nicotine at high doses

Hexamethoinum and Tetraethylammonium

Mecamylamine and Trimethaphan

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8
Q

Hexamethonium and Tetraethylammonium

A

Quaternary amines, poorly absorbed

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9
Q

Mecamylamine and Tetraethylammonium

A

Tertiary amines, better absorbed, also more penetration to CNS.

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10
Q

Effects of ganglion blockers

A

nonspecific inhibition of both the sympathetic and parasympathetic

Vasodilation and hypotension

Tachycardia

mydriasis

constipation, urinary retention,
xerostomia, and anhydrosis.

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pharma final (42 decks)

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