Antiemetics Flashcards
List the antiemetic drug classes used
7
5HT3 blockers
D2 blockers
H1 blockers
M1 blockers
NK1 blockers
Cannabinoids
Glucocorticoids
List the 5HT3 blockers
Ondansetron
Granisetron
List the D2 blocker anti emetics
Metoclopromide
Domiperidone
AND many of the antipsychotics, used at LOW doses. Antiemetic effects before AP effects
most common:
Prochlorperazine
Also:
Promethazine
Chlorpromazine
H1 blocker antiemetics
Diphenhydramine
Dimenhydrinate
Promethazine
Meclinzine
Antimuscarinic antiemetics
Scopolamine
Dimenhydrinate
Cannabinoids
Dronabinol - THC
Nabilone - analog
Which glucocorticoids are used as antiemetics
Dexamethasone
Methylprednisolone
NK1 blockers
Aprepitatnt
Fosaprepitant
What is the NK1 a receptor for
Substance P, aka Neurokinin
Serious side effects of Ondansetron
Long QT syndrome and torsades
Serotonin syndrome, esp with SSRIs
Metoclopromide SEs
Diarrhea
Extrapyramidal SEs, tremors, tardive dyskinesia
Long QT, torsades
Rhabdomyolysis
Neuroleptic malignant syndrome
Hyperprotlactinemia, galactorrhea, impotence
Sedation
What is Neuroleptic malignant synd
Symptoms include high fever, confusion, rigid muscles, variable blood pressure, sweating, and fast heart rate
What is serotonin syndrome
High fever, Confusion, Hallucinations Hypomania Headache, Tachycardia Nausea and Diarrhea
Muscle Twictching, fasciculations, tremor, and hyperreflexia.
What are the drugs used to treat obesity
Anorexiants:
- Phentermine
- Diethylpropion
Both are monoamine releasers,
Inhibit NET/DAT, amphetamine like effects and potential for abuse
Lipase inhibitor
- Orlistat
What are the prokinetic drugs
4 classes
6 drugs
D2 antagonists AND 5HT4 Agonists
-Metoclopromide and Domperidone
Muscarinics
- Bethanachol
- Neostigmine
5HT4 agonists, 5HT3 antagonists
Cisapride
Erythromycin
