Androgens, anabolic steroids and antiandrogens

Question 1

Endogenous androgens

Answer 1

Androstenedione
DHEA
Testosterone
DHT

Question 2

Synthetic androgens with high anabolic actions

Answer 2

Stanozolol

Oxandrolone

Question 3

Synthetic testosterone

Answer 3

Methyltestosterone

Question 4

Indications of androgen steroid treatment

Answer 4

Hormone replacement for hypogonadism or after castration

Anabolic stimulation after trauma, surgery, prolonged immobilization

Danazol and Stanozolol - used to treat hereditary angioedema. Long term use increases C1 esterase inhibitor synthesis.

Question 5

What is unique about Danazol

Answer 5

It is a partial agaonist at androgen receptors

Used to treat endometriosis

Question 6

SEs of androgen steroids

Answer 6

Hirsutism

Acne

Cardiovascular risk

Na+ retention and edema

Hepatic dysfunciton, elevated liver enzymes

Prostate hyperplasia
Exacerbation of prostate malignancies

Endometrial bleeding on halting

Question 7

List the antiandrogens

Answer 7

Ketoconazole

Abiraterone

Finasteride
Dutasteride

Flutamide
Bicalutamide
Nilutamide

Spironolactone

Cyproterone acetate

Question 8

Flutamide action, other drugs in the class

Answer 8

Flutamide,
Bicalutamide
Niluatmide

Potent, selective androgen receptor antagonists

For Prostate carcinoma treatment

Question 9

The 5alpha reductase inhibitors

Answer 9

Finasteride,
Dutasteride

Dutasteride is longer acting

For BPH, bladness, and hirsutism

Question 10

Cyproterone acetate

Answer 10

Androgen inhibitor and strong progesterone receptor activator.

For hirsutism in women, PCOS, and allopecia

also adjunct treatment in prostate cancer

Question 11

How does ketoconazole inhibit androgens

Answer 11

Inhibits CYPscc enzyme

Question 12

Abiraterone

mechanism and use

Answer 12

Abiraterone
Inhibits 17 hydroxylase.

Inhibiting the produciton of all steroieds except cortisol.

Used in prostate cancer.

Question 13

‘Agents affecting sexual activity’

Answer 13

GnRH analogs
GnRH antagoinsts

FSH analogs

LH analogs

Question 14

GnRH analogs

Answer 14

Leuprolide - in Leu of GnRH

and
the -relins

Goserelin
Buserelin

Question 15

GnRH antagonists

Answer 15

the - relix (the relics, like our gan)

Ganirelix

Question 16

GnRH agonist vs antagonist

Answer 16

Goserelin v Ganirelix

Question 17

FSH function

Answer 17

stimulates
Gametogenesis in men and women
Follicular development in women

Question 18

FSH drugs

Answer 18

Follitropin beta - modified human FSH

Urofollitropin - isolated from post menopausal women’s urine, free of LH

hMG, menotropin

Question 19

hMG, menotropin

Answer 19

FSH-LH combination

Question 20

Indications for FSH treatment

Answer 20

Pituitary or hypothalamic hypogonadism causing infertility

Fertilizaiton programs.

Question 21

LH function

Answer 21

Stimulates steroid hormone production and secretion by the gonads.

Question 22

LH clinical use

Answer 22

not used,

Instead, hCG is used

Question 23

hCG use

Answer 23

To diagnose cryptorchidism in prepubertal boys.

• LH can stimulate Testosterone if they are just retained, pseudocryptorchid.
• It is not effected if they are truly undesceded and underdeveloped
• Stimulate Testosterone in hypogonadotropic hypogonadism

Induces ovulation (Estrogen mid-cycle peak induces LH surge, induces ovulation)

AIDS related kaposi sarcoma!

hCG direct injection can cause lesion regression