Chemotherapy Part 1 and 2 Flashcards
Platinum Compound?
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Cisplatin
Vinca Alkaloids
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Vincristine
Anthracyclines-
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Doxorubicin
Nitrogen Mustard
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Cyclophosphamide
Antimetabolites
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Methotrexate
Monoclonal Antibody- Anti-HER2
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Trastuzumab
USED TO TREAT- Wide array of cancers
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Doxorubicin - Anthracyclines
MECHANISM:
Inhibits DNA and RNA synthesis
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Doxorubicin - Anthracyclines
Cisplatin - Platinum Compound
Cyclophosphamide - Nitrogen Mustards
Vincristine - Vinca Alkaloids
ADVERSE EFFECTS:
BAD GOATS
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Doxorubicin - Anthracyclines Cisplatin - Platinum Compound Cyclophosphamide - Nitrogen Mustards Vincristine - Vinca Alkaloids Methotrexate Antimetabolites/DMARD:
ADVERSE EFFECTS:
Alopecia
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Doxorubicin - Anthracyclines
Methotrexate Antimetabolites/DMARD:
Doxorubicin - Anthracyclines
Starts ?-? days when beginning treatmentCan last ? months after end of treatment
Doxorubicin - Anthracyclines
Starts 7-10 days when beginning treatmentCan last 2 months after end of treatment
Adverse SE
(ruby red)
(Harmless or Harmful) red discoloration of bodily fluids
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Doxorubicin - Anthracyclines
Harmless
Monitor EKG and Echocardiogram
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Doxorubicin - Anthracyclines
USED TO TREAT-
Derived from vinca rosea plant (peri-winkle plant)
Wide array of cancers
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Vincristine- Vinca alkaloids
Peripheral Neuropathy
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Vincristine- Vinca alkaloids
Nearly all patients
Peripheral Neuropathy
Decreased reflexesWeaknessSensory LossParesthesias (numbness/tingling)
Constipation Urinary hesitancy/retention
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Vincristine- Vinca alkaloids
Educate patients on S/S of peripheral neuropathy
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Vincristine- Vinca alkaloids
Educate patients on S/S of peripheral neuropathy
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Vincristine- Vinca alkaloids
USED TO TREAT-
Wide array of cancers
Includes acute lymphomas; solidtumors (head, neck, ovary and breast cancers);
Hodgkin’sand non‑Hodgkin’s lymphomas; and multiple myeloma
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Cyclophosphamide - Nitrogen Mustards
Adverse SE
Acute Hemorrhagic Cystitis
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Cyclophosphamide - Nitrogen Mustards
Acute Hemorrhagic Cystitis Increase fluids to 3 Liters/Day Monitor for blood in urine Watch out for electrolyte abnormalities hyperkalemia
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Cyclophosphamide - Nitrogen Mustards
Commonly given with Mesna (uro-protectant)
for protection
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Cyclophosphamide - Nitrogen Mustards
Cyclophosphamide - Nitrogen Mustards
Increase fluids to ? Liters/Day- Administer with ? to reduce risk to bladder
3
Mesna
Cyclophosphamide =
Mesna
USED TO TREAT- Wide array of cancers
Includes bladder, testicular, and ovarian cancers
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Cisplatin - Platinum Compound
Highly Emetogenic
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Cisplatin - Platinum Compound
Renal Toxicity
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Cisplatin - Platinum Compound
Hearing Loss
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Cisplatin - Platinum Compound
Paresthesia’s
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Cisplatin - Platinum Compound
ADMINISTRATIONMonitor and manage extravasation
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Doxorubicin - Anthracyclines
Cisplatin - Platinum Compound
Cyclophosphamide - Nitrogen Mustards
Vincristine - Vinca Alkaloids
USED TO TREAT- Solid Tumors (breast/lung) Lymphomas/Leukemia Rheumatoid Arthritis Ectopic Pregnancy
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Methotrexate Antimetabolites/DMARD:
Low Dose = Rheumatoid Arthritis
High Dose= Cancer
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Methotrexate Antimetabolites/DMARD:
Methotrexate Antimetabolites/DMARD:
? Dose= Cancer
Low or High
High Dose= Cancer
Methotrexate Antimetabolites/DMARD:
? Dose = Rheumatoid Arthritis
Low or High
Low Dose = Rheumatoid Arthritis
Inhibits use of folic acid in DNA, thus stopping DNA production
Reduces inflammation
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Methotrexate Antimetabolites/DMARD:
The Good: Kills Cancer or stops overactive immune system (RA)!
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Methotrexate Antimetabolites/DMARD:
Leucovorin Rescue (sort of an antidote)
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Methotrexate Antimetabolites/DMARD:
Methotrexate Antimetabolites/DMARD:
? WEEKLY! Patients have died when someone accidentally writes ? daily
Methotrexate Antimetabolites/DMARD:
ONCE WEEKLY! Patients have died when someone accidentally writes once daily
Pregnancy Category X
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Methotrexate Antimetabolites/DMARD:
Targets highly proliferative cells
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Methotrexate Antimetabolites/DMARD:
GI Tract,
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Methotrexate Antimetabolites/DMARD:
Bone Marrow (blood dyscrasias/pancytopenia)
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Methotrexate Antimetabolites/DMARD:
Kidney/LiverSCAR/Photosensitivity
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Methotrexate Antimetabolites/DMARD:
USED TO TREAT- HER2+ Breast Cancer
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Trastuzumab - Monoclonal Antibody- Anti-HER2
TWO BOXED WARNINGS
:CARDIOMYOPATHY HEART FAILURE
INFUSION REACTIONS AND PULMONARY TOXICITYStop immediately if dyspnea or significant hypotension
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Trastuzumab - Monoclonal Antibody- Anti-HER2
CARDIOMYOPATHY HEART FAILURE
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Trastuzumab - Monoclonal Antibody- Anti-HER2
INFUSION REACTIONS AND PULMONARY TOXICITYStop immediately if dyspnea or significant hypotension
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Trastuzumab - Monoclonal Antibody- Anti-HER2
ADMINISTRATION Monitor vitals during infusion
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Trastuzumab - Monoclonal Antibody- Anti-HER2
? is a monoclonal antibody which binds to the extracellular domain of the human epidermal growth factor receptor 2 protein (HER-2)
Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate
Trastuzumab - Monoclonal Antibody- Anti-HER2