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Phamacology > Chemotherapy Part 1 and 2 > Flashcards

Chemotherapy Part 1 and 2 Flashcards

1
Q

Platinum Compound?

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Cisplatin

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2
Q

Vinca Alkaloids

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Vincristine

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3
Q

Anthracyclines-

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Doxorubicin

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4
Q

Nitrogen Mustard

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Cyclophosphamide

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5
Q

Antimetabolites

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Methotrexate

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6
Q

Monoclonal Antibody- Anti-HER2

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Trastuzumab

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7
Q

USED TO TREAT- Wide array of cancers

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Doxorubicin - Anthracyclines

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8
Q

MECHANISM:
Inhibits DNA and RNA synthesis

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Doxorubicin - Anthracyclines
Cisplatin - Platinum Compound
Cyclophosphamide - Nitrogen Mustards
Vincristine - Vinca Alkaloids

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9
Q

ADVERSE EFFECTS:
BAD GOATS

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A 
Doxorubicin - Anthracyclines
Cisplatin - Platinum Compound
Cyclophosphamide - Nitrogen Mustards
Vincristine - Vinca Alkaloids
Methotrexate Antimetabolites/DMARD:
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10
Q

ADVERSE EFFECTS:
Alopecia

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Doxorubicin - Anthracyclines

Methotrexate Antimetabolites/DMARD:

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11
Q

Doxorubicin - Anthracyclines

Starts ?-? days when beginning treatmentCan last ? months after end of treatment

A

Doxorubicin - Anthracyclines

Starts 7-10 days when beginning treatmentCan last 2 months after end of treatment

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12
Q

Adverse SE
(ruby red)
(Harmless or Harmful) red discoloration of bodily fluids

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Doxorubicin - Anthracyclines

Harmless

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13
Q

Monitor EKG and Echocardiogram

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Doxorubicin - Anthracyclines

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14
Q

USED TO TREAT-
Derived from vinca rosea plant (peri-winkle plant)
Wide array of cancers

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Vincristine- Vinca alkaloids

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15
Q

Peripheral Neuropathy

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Vincristine- Vinca alkaloids

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16
Q

Nearly all patients
Peripheral Neuropathy
Decreased reflexesWeaknessSensory LossParesthesias (numbness/tingling)
Constipation Urinary hesitancy/retention

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Vincristine- Vinca alkaloids

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17
Q

Educate patients on S/S of peripheral neuropathy

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Vincristine- Vinca alkaloids

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18
Q

Educate patients on S/S of peripheral neuropathy

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Vincristine- Vinca alkaloids

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19
Q

USED TO TREAT-
Wide array of cancers
Includes acute lymphomas; solidtumors (head, neck, ovary and breast cancers);
Hodgkin’sand non‑Hodgkin’s lymphomas; and multiple myeloma

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Cyclophosphamide - Nitrogen Mustards

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20
Q

Adverse SE
Acute Hemorrhagic Cystitis

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Cyclophosphamide - Nitrogen Mustards

21
Q 
Acute Hemorrhagic Cystitis
Increase fluids to 3 Liters/Day
Monitor for blood  in urine
Watch out for electrolyte abnormalities
hyperkalemia
Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Cyclophosphamide - Nitrogen Mustards

22
Q

Commonly given with Mesna (uro-protectant)
for protection

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Cyclophosphamide - Nitrogen Mustards

23
Q

Cyclophosphamide - Nitrogen Mustards

Increase fluids to ? Liters/Day- Administer with ? to reduce risk to bladder

A

3

Mesna

24
Q

Cyclophosphamide =

A

Mesna

25
Q

USED TO TREAT- Wide array of cancers
Includes bladder, testicular, and ovarian cancers

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Cisplatin - Platinum Compound

26
Q

Highly Emetogenic

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Cisplatin - Platinum Compound

27
Q

Renal Toxicity

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Cisplatin - Platinum Compound

28
Q

Hearing Loss

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Cisplatin - Platinum Compound

29
Q

Paresthesia’s

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Cisplatin - Platinum Compound

30
Q

ADMINISTRATIONMonitor and manage extravasation

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Doxorubicin - Anthracyclines
Cisplatin - Platinum Compound
Cyclophosphamide - Nitrogen Mustards
Vincristine - Vinca Alkaloids

31
Q 
USED TO TREAT- 
Solid Tumors (breast/lung)
Lymphomas/Leukemia
Rheumatoid Arthritis
Ectopic Pregnancy
Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Methotrexate Antimetabolites/DMARD:

32
Q

Low Dose = Rheumatoid Arthritis
High Dose= Cancer

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Methotrexate Antimetabolites/DMARD:

33
Q

Methotrexate Antimetabolites/DMARD:
? Dose= Cancer

Low or High

A

High Dose= Cancer

34
Q

Methotrexate Antimetabolites/DMARD:
? Dose = Rheumatoid Arthritis

Low or High

A

Low Dose = Rheumatoid Arthritis

35
Q

Inhibits use of folic acid in DNA, thus stopping DNA production
Reduces inflammation

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Methotrexate Antimetabolites/DMARD:

36
Q

The Good: Kills Cancer or stops overactive immune system (RA)!

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Methotrexate Antimetabolites/DMARD:

37
Q

Leucovorin Rescue (sort of an antidote)

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Methotrexate Antimetabolites/DMARD:

38
Q

Methotrexate Antimetabolites/DMARD:

? WEEKLY! Patients have died when someone accidentally writes ? daily

A

Methotrexate Antimetabolites/DMARD:

ONCE WEEKLY! Patients have died when someone accidentally writes once daily

39
Q

Pregnancy Category X

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Methotrexate Antimetabolites/DMARD:

40
Q

Targets highly proliferative cells

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Methotrexate Antimetabolites/DMARD:

41
Q

GI Tract,

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Methotrexate Antimetabolites/DMARD:

42
Q

Bone Marrow (blood dyscrasias/pancytopenia)

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Methotrexate Antimetabolites/DMARD:

43
Q

Kidney/LiverSCAR/Photosensitivity

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Methotrexate Antimetabolites/DMARD:

44
Q

USED TO TREAT- HER2+ Breast Cancer

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Trastuzumab - Monoclonal Antibody- Anti-HER2

45
Q

TWO BOXED WARNINGS
:CARDIOMYOPATHY HEART FAILURE

INFUSION REACTIONS AND PULMONARY TOXICITYStop immediately if dyspnea or significant hypotension

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Trastuzumab - Monoclonal Antibody- Anti-HER2

46
Q

CARDIOMYOPATHY HEART FAILURE

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Trastuzumab - Monoclonal Antibody- Anti-HER2

47
Q

INFUSION REACTIONS AND PULMONARY TOXICITYStop immediately if dyspnea or significant hypotension

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Trastuzumab - Monoclonal Antibody- Anti-HER2

48
Q

ADMINISTRATION Monitor vitals during infusion

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Trastuzumab - Monoclonal Antibody- Anti-HER2

49
Q

? is a monoclonal antibody which binds to the extracellular domain of the human epidermal growth factor receptor 2 protein (HER-2)

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Trastuzumab - Monoclonal Antibody- Anti-HER2

Phamacology (13 decks)

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