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Phamacology > Chemotherapy Part 1 and 2 > Flashcards

Chemotherapy Part 1 and 2 Flashcards

1
Q

Platinum Compound?

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Cisplatin

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2
Q

Vinca Alkaloids

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Vincristine

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3
Q

Anthracyclines-

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Doxorubicin

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4
Q

Nitrogen Mustard

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Cyclophosphamide

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5
Q

Antimetabolites

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Methotrexate

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6
Q

Monoclonal Antibody- Anti-HER2

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Trastuzumab

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7
Q

USED TO TREAT- Wide array of cancers

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Doxorubicin - Anthracyclines

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8
Q

MECHANISM:
Inhibits DNA and RNA synthesis

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Doxorubicin - Anthracyclines
Cisplatin - Platinum Compound
Cyclophosphamide - Nitrogen Mustards
Vincristine - Vinca Alkaloids

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9
Q

ADVERSE EFFECTS:
BAD GOATS

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A 
Doxorubicin - Anthracyclines
Cisplatin - Platinum Compound
Cyclophosphamide - Nitrogen Mustards
Vincristine - Vinca Alkaloids
Methotrexate Antimetabolites/DMARD:
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10
Q

ADVERSE EFFECTS:
Alopecia

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Doxorubicin - Anthracyclines

Methotrexate Antimetabolites/DMARD:

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11
Q

Doxorubicin - Anthracyclines

Starts ?-? days when beginning treatmentCan last ? months after end of treatment

A

Doxorubicin - Anthracyclines

Starts 7-10 days when beginning treatmentCan last 2 months after end of treatment

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12
Q

Adverse SE
(ruby red)
(Harmless or Harmful) red discoloration of bodily fluids

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Doxorubicin - Anthracyclines

Harmless

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13
Q

Monitor EKG and Echocardiogram

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Doxorubicin - Anthracyclines

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14
Q

USED TO TREAT-
Derived from vinca rosea plant (peri-winkle plant)
Wide array of cancers

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Vincristine- Vinca alkaloids

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15
Q

Peripheral Neuropathy

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Vincristine- Vinca alkaloids

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16
Q

Nearly all patients
Peripheral Neuropathy
Decreased reflexesWeaknessSensory LossParesthesias (numbness/tingling)
Constipation Urinary hesitancy/retention

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Vincristine- Vinca alkaloids

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17
Q

Educate patients on S/S of peripheral neuropathy

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Vincristine- Vinca alkaloids

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18
Q

Educate patients on S/S of peripheral neuropathy

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Vincristine- Vinca alkaloids

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19
Q

USED TO TREAT-
Wide array of cancers
Includes acute lymphomas; solidtumors (head, neck, ovary and breast cancers);
Hodgkin’sand non‑Hodgkin’s lymphomas; and multiple myeloma

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Cyclophosphamide - Nitrogen Mustards

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20
Q

Adverse SE
Acute Hemorrhagic Cystitis

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Cyclophosphamide - Nitrogen Mustards

21
Q 
Acute Hemorrhagic Cystitis
Increase fluids to 3 Liters/Day
Monitor for blood  in urine
Watch out for electrolyte abnormalities
hyperkalemia

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Cyclophosphamide - Nitrogen Mustards

22
Q

Commonly given with Mesna (uro-protectant)
for protection

Doxorubicin
Cisplatin
Trastuzumab
Cyclophosphamide
Vincristine
Methotrexate
A

Cyclophosphamide - Nitrogen Mustards

23
Q

Cyclophosphamide - Nitrogen Mustards

Increase fluids to ? Liters/Day- Administer with ? to reduce risk to bladder

24
Q

Cyclophosphamide =

25
USED TO TREAT- Wide array of cancers Includes bladder, testicular, and ovarian cancers ``` Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate ```
Cisplatin - Platinum Compound
26
Highly Emetogenic ``` Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate ```
Cisplatin - Platinum Compound
27
Renal Toxicity ``` Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate ```
Cisplatin - Platinum Compound
28
Hearing Loss ``` Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate ```
Cisplatin - Platinum Compound
29
Paresthesia's ``` Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate ```
Cisplatin - Platinum Compound
30
ADMINISTRATIONMonitor and manage extravasation ``` Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate ```
Doxorubicin - Anthracyclines Cisplatin - Platinum Compound Cyclophosphamide - Nitrogen Mustards Vincristine - Vinca Alkaloids
31
``` USED TO TREAT- Solid Tumors (breast/lung) Lymphomas/Leukemia Rheumatoid Arthritis Ectopic Pregnancy ``` ``` Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate ```
Methotrexate Antimetabolites/DMARD:
32
Low Dose = Rheumatoid Arthritis High Dose= Cancer ``` Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate ```
Methotrexate Antimetabolites/DMARD:
33
Methotrexate Antimetabolites/DMARD: ? Dose= Cancer Low or High
High Dose= Cancer
34
Methotrexate Antimetabolites/DMARD: ? Dose = Rheumatoid Arthritis Low or High
Low Dose = Rheumatoid Arthritis
35
Inhibits use of folic acid in DNA, thus stopping DNA production Reduces inflammation ``` Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate ```
Methotrexate Antimetabolites/DMARD:
36
The Good: Kills Cancer or stops overactive immune system (RA)! ``` Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate ```
Methotrexate Antimetabolites/DMARD:
37
Leucovorin Rescue (sort of an antidote) ``` Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate ```
Methotrexate Antimetabolites/DMARD:
38
Methotrexate Antimetabolites/DMARD: | ? WEEKLY! Patients have died when someone accidentally writes ? daily
Methotrexate Antimetabolites/DMARD: | ONCE WEEKLY! Patients have died when someone accidentally writes once daily
39
Pregnancy Category X ``` Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate ```
Methotrexate Antimetabolites/DMARD:
40
Targets highly proliferative cells ``` Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate ```
Methotrexate Antimetabolites/DMARD:
41
GI Tract, ``` Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate ```
Methotrexate Antimetabolites/DMARD:
42
Bone Marrow (blood dyscrasias/pancytopenia) ``` Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate ```
Methotrexate Antimetabolites/DMARD:
43
Kidney/LiverSCAR/Photosensitivity ``` Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate ```
Methotrexate Antimetabolites/DMARD:
44
USED TO TREAT- HER2+ Breast Cancer ``` Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate ```
Trastuzumab - Monoclonal Antibody- Anti-HER2
45
TWO BOXED WARNINGS :CARDIOMYOPATHY HEART FAILURE INFUSION REACTIONS AND PULMONARY TOXICITYStop immediately if dyspnea or significant hypotension ``` Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate ```
Trastuzumab - Monoclonal Antibody- Anti-HER2
46
CARDIOMYOPATHY HEART FAILURE ``` Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate ```
Trastuzumab - Monoclonal Antibody- Anti-HER2
47
INFUSION REACTIONS AND PULMONARY TOXICITYStop immediately if dyspnea or significant hypotension ``` Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate ```
Trastuzumab - Monoclonal Antibody- Anti-HER2
48
ADMINISTRATION Monitor vitals during infusion ``` Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate ```
Trastuzumab - Monoclonal Antibody- Anti-HER2
49
? is a monoclonal antibody which binds to the extracellular domain of the human epidermal growth factor receptor 2 protein (HER-2) ``` Doxorubicin Cisplatin Trastuzumab Cyclophosphamide Vincristine Methotrexate ```
Trastuzumab - Monoclonal Antibody- Anti-HER2

Phamacology (13 decks)

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