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Phamacology > Brief Overview of Substance Use Disorder Pharmacotherapy > Flashcards

Brief Overview of Substance Use Disorder Pharmacotherapy Flashcards

1
Q

Nicotine Withdrawal/Abstinence

Varenicline
Bupropion
Nicotine Replacement

A

Bupropion
Varenicline
Nicotine Replacement

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2
Q

Treat:
Smoking cessation
Weight loss
lots of off label uses (used to treat sexual dysfunction)

Varenicline
Bupropion
Nicotine Replacement

A

Bupropion- Nicotine Withdrawal/Abstinence

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3
Q

MECHANISM OF ACTION
Weak inhibitor of the neuronal uptake of norepinephrine and dopamine (minimal to no serotonin activity)+ antagonist nicotinic receptors

Varenicline
Bupropion
Nicotine Replacement

A

Bupropion- Nicotine Withdrawal/Abstinence

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4
Q

ADVERSE EFFECTS
Same as SSRIs (except this can potentially treat sexual dysfunction)

Varenicline
Bupropion
Nicotine Replacement

A

Bupropion- Nicotine Withdrawal/Abstinence

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5
Q

SEIZURES (AVOID in HX of Seizures)

Varenicline
Bupropion
Nicotine Replacement

A

Bupropion- Nicotine Withdrawal/Abstinence

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6
Q

Administration
Takes minimum 1 month to maximum of 3 months to see benefit (if no response after 1 month, try alternative agent) TAKE WITH FOOD! (SICK STOMACH)

Varenicline
Bupropion
Nicotine Replacement

A

Bupropion- Nicotine Withdrawal/Abstinence

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7
Q

Bupropion- Nicotine Withdrawal/Abstinence
Administration
Takes minimum ? month to maximum of ? months to see benefit (if no response after 1 month, try alternative agent)

A

1

3

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8
Q

TAKE WITH FOOD! (SICK STOMACH)

Varenicline
Bupropion
Nicotine Replacement

A

Bupropion- Nicotine Withdrawal/Abstinence

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9
Q

Treat:
SMOKING CESSATION

Varenicline
Bupropion
Nicotine Replacement

A

Varenicline - Nicotine Withdrawal/Abstinence

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10
Q

MECHANISM OF ACTION
Partial Nicotine agonist- doesn’t activate the dopamine reward pathway associated with nicotine addiction

Varenicline
Bupropion
Nicotine Replacement

A

Varenicline - Nicotine Withdrawal/Abstinence

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11
Q

ADVERSE EFFECTS
Similar to Bupropion- can see Neuropsychiatric effects- vivid dreams, depression, mood changes, thoughts of suicide

Varenicline
Bupropion
Nicotine Replacement

A

Varenicline - Nicotine Withdrawal/Abstinence

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12
Q

Nursing Considerations
Reduce the cravings of nicotine and reduce the severity of withdrawal manifestations

Varenicline
Bupropion
Nicotine Replacement

A

Varenicline - Nicotine Withdrawal/Abstinence

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13
Q

Unintended Outcomes
Neuropsychiatric effect

Varenicline
Bupropion
Nicotine Replacement

A

Varenicline - Nicotine Withdrawal/Abstinence

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14
Q

Administration
NOTHING SPECIAL- BUT THIS IS TITRATABLE- THIS DRUG COMES IN DOSAGE PACKS THAT TAPER YOU DOWN

Varenicline
Bupropion
Nicotine Replacement

A

Varenicline - Nicotine Withdrawal/Abstinence

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15
Q

Treat:
Use substitute nicotine instead of chewing tobacco/cigarettes, etc.

Varenicline
Bupropion
Nicotine Replacement

A

Nicotine Replacement Therapy - Nicotine Withdrawal/Abstinence

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16
Q 
Nursing Considerations
Work on tapering these down (gum max 6 months use)
Nicotine Lozenges
Nicotine Gum
Nicotine Patch
Nicotine Nasal Spray
Nicotine Inhaler

Varenicline
Bupropion
Nicotine Replacement

A

Nicotine Replacement Therapy - Nicotine Withdrawal/Abstinence

17
Q

Nicotine Replacement

Nursing Considerations
Work on tapering these down (gum max ? months use)
Nicotine Lozenges
Nicotine Gum
Nicotine Patch
Nicotine Nasal Spray
Nicotine Inhaler
18
Q

Nicotine Replacement Therapy - Nicotine Withdrawal/Abstinence

Allow lozenge to dissolve in mouth
avoid any oral products (food/drinks) 15 minutes prior or during use.

Nicotine Gum, Nicotine Lozenges, Nicotine Patch

A

Nicotine Lozenges

19
Q

Nicotine Replacement Therapy - Nicotine Withdrawal/Abstinence

Chew slowly and intermittently
avoid any oral products (food/drinks) 15 minutes prior or during use

Nicotine Gum, Nicotine Lozenges, Nicotine Patch

A

Nicotine Gum

20
Q

Nicotine Replacement Therapy - Nicotine Withdrawal/Abstinence

May contain metal (avoid wearing in MRI machine)
As with all patches, apply to clean, dry, hairless area
New patch daily

Nicotine Gum, Nicotine Lozenges, Nicotine Patch

A

Nicotine Patch

21
Q

Absence of injury (prevent seizures, DT’s, neurological damage, etc.)

Varenicline
Bupropion
Nicotine Replacement

A

Nicotine Replacement Therapy - Nicotine Withdrawal/Abstinence

22
Q

Decreased cravings for substance
Abstinence from substance

Varenicline
Bupropion
Nicotine Replacement

A

Nicotine Replacement Therapy - Nicotine Withdrawal/Abstinence

Phamacology (13 decks)

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