Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Phamacology > Anemia, Hematopoietic > Flashcards

Anemia, Hematopoietic Flashcards

1
Q

ANEMIA?

Folic Acid and Cyanocobalamin
Epoetin alfa (Epogen®)
Darbepoetin alfa
Iron dextran (INFed®)
Ferrous sulfate 
Filgrastim (Neupogen®)
Sargramostim
A

Ferrous sulfate (Feosol®)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Parenteral Iron?

Folic Acid and Cyanocobalamin
Epoetin alfa (Epogen®)
Darbepoetin alfa
Iron dextran (INFed®)
Ferrous sulfate 
Filgrastim (Neupogen®)
Sargramostim
A

Iron dextran (INFed®)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

B Vitamins?

Folic Acid and Cyanocobalamin
Epoetin alfa (Epogen®)
Darbepoetin alfa
Iron dextran (INFed®)
Ferrous sulfate 
Filgrastim (Neupogen®)
Sargramostim
A

Folic Acid and Cyanocobalamin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

ESA- Erythropoietin Stimulating Agent?

Folic Acid and Cyanocobalamin
Epoetin alfa (Epogen®)
Darbepoetin alfa
Iron dextran (INFed®)
Ferrous sulfate 
Filgrastim (Neupogen®)
Sargramostim
A 
Epoetin alfa (Epogen®)
Darbepoetin alfa
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

G-CSF- Granulocyte Colony Stimulating Factor?

Folic Acid and Cyanocobalamin
Epoetin alfa (Epogen®)
Darbepoetin alfa
Iron dextran (INFed®)
Ferrous sulfate 
Filgrastim (Neupogen®)
Sargramostim
A

Filgrastim (Neupogen®)

Sargramostim

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Which deals with Anemias

Bone Marrow
Nausea
Erythropoietin
Vomiting
Iron, folic acid, B12
Diarrhia
Cyanocobalamin
A

Bone Marrow
Erythropoietin
Iron, folic acid, B12
Cyanocobalamin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Building blocks for erythrocytes?

Bone Marrow
Iron, folic acid, B12(cyanocobalamin)
Erythropoietin

A

Iron, folic acid, B12(cyanocobalamin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Synthesis of erythrocytes

Bone Marrow
Iron, folic acid, B12(cyanocobalamin)
Erythropoietin

A

Bone Marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Stimulates bone marrow

Bone Marrow
Iron, folic acid, B12(cyanocobalamin)
Erythropoietin

A

Erythropoietin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What happens if the following are low?
Bone Marrow
Iron, folic acid, B12(cyanocobalamin)
Erythropoietin

A

Anemia will result

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

USED TO TREAT
Iron deficiency anemia
Prevention
Treatment

Folic Acid and Cyanocobalamin
Epoetin alfa (Epogen®)
Darbepoetin alfa
Iron dextran (INFed®)
Ferrous sulfate 
Filgrastim (Neupogen®)
Sargramostim
A

Ferrous sulfate- Oral Iron Products:

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

MECHANISM OF ACTION:Iron replenishment for the body when dietary is insufficient (or excessive loss has occurred)

Folic Acid and Cyanocobalamin
Epoetin alfa (Epogen®)
Darbepoetin alfa
Iron dextran (INFed®)
Ferrous sulfate 
Filgrastim (Neupogen®)
Sargramostim
A

Ferrous sulfate- Oral Iron Products:

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

ADVERSE EFFECTS- ◦
GI TRACT◦
nausea, heartburn, bloating, constipation

Folic Acid and Cyanocobalamin
Epoetin alfa (Epogen®)
Darbepoetin alfa
Iron dextran (INFed®)
Ferrous sulfate 
Filgrastim (Neupogen®)
Sargramostim
A

Ferrous sulfate- Oral Iron Products:

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Liquid can STAIN teeth?

Folic Acid and Cyanocobalamin
Epoetin alfa (Epogen®)
Darbepoetin alfa
Iron dextran (INFed®)
Ferrous sulfate 
Filgrastim (Neupogen®)
Sargramostim
A

Ferrous sulfate- Oral Iron Products:

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Both forms can “stain” a bowel movement- black stool normal?

Folic Acid and Cyanocobalamin
Epoetin alfa (Epogen®)
Darbepoetin alfa
Iron dextran (INFed®)
Ferrous sulfate 
Filgrastim (Neupogen®)
Sargramostim
A

Ferrous sulfate- Oral Iron Products:

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which of the following you should do with Oral Iron Products: Ferrous Sulfate?

Rinse mouth!
Dilute with water or juice
Dilute with Alcohol
Drink with a Straw
Drink with a cup.
A

Rinse mouth!
Dilute with water or juice
Drink with a Straw

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Game plan: Take on an empty stomach for BEST absorption?

Folic Acid and Cyanocobalamin
Epoetin alfa (Epogen®)
Darbepoetin alfa
Iron dextran (INFed®)
Ferrous sulfate 
Filgrastim (Neupogen®)
Sargramostim
A

Ferrous sulfate- Oral Iron Products:

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

GI UPSET- then take with food (last case resort)

Folic Acid and Cyanocobalamin
Epoetin alfa (Epogen®)
Darbepoetin alfa
Iron dextran (INFed®)
Ferrous sulfate 
Filgrastim (Neupogen®)
Sargramostim
A

Ferrous sulfate- Oral Iron Products:

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

ABSORPTION:
Increase: Vitamin C/ ascorbic acid

Folic Acid and Cyanocobalamin
Epoetin alfa (Epogen®)
Darbepoetin alfa
Iron dextran (INFed®)
Ferrous sulfate 
Filgrastim (Neupogen®)
Sargramostim
A

Ferrous sulfate- Oral Iron Products:

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

ABSORPTION:
Decrease: Caffeine/Tea/Dairy (calcium)

Folic Acid and Cyanocobalamin
Epoetin alfa (Epogen®)
Darbepoetin alfa
Iron dextran (INFed®)
Ferrous sulfate 
Filgrastim (Neupogen®)
Sargramostim
A

Ferrous sulfate- Oral Iron Products:

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Iron has
Does DRUG-DRUG interaction or
Doesn’t have DRUG-DRUG Interaction

A

Does DRUG-DRUG interaction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Avoid administering with oral antibiotics (fluoroquinolones and tetracyclines)

Folic Acid and Cyanocobalamin
Epoetin alfa (Epogen®)
Darbepoetin alfa
Iron dextran (INFed®)
Ferrous sulfate 
Filgrastim (Neupogen®)
Sargramostim
A

Ferrous sulfate- Oral Iron Products:

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Avoid caffeine + dairy

Folic Acid and Cyanocobalamin
Epoetin alfa (Epogen®)
Darbepoetin alfa
Iron dextran (INFed®)
Ferrous sulfate 
Filgrastim (Neupogen®)
Sargramostim
A

Ferrous sulfate- Oral Iron Products:

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Severe N/V/D, shock, liver/heart failure

Folic Acid and Cyanocobalamin
Epoetin alfa (Epogen®)
Darbepoetin alfa
Iron dextran (INFed®)
Ferrous sulfate 
Filgrastim (Neupogen®)
Sargramostim
A

Ferrous sulfate- Oral Iron Products:

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Most common cause of pediatric poisoning deaths ``` Folic Acid and Cyanocobalamin Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Ferrous sulfate- Oral Iron Products:
26
Children can appear asymptomatic ``` Folic Acid and Cyanocobalamin Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Ferrous sulfate- Oral Iron Products:
27
Overdose: ANTIDOTE: deferoxamine (Desferal ®) ``` Folic Acid and Cyanocobalamin Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Ferrous sulfate- Oral Iron Products:
28
Warn about toxicity in children!!! ``` Folic Acid and Cyanocobalamin Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Ferrous sulfate- Oral Iron Products:
29
Avoid co-administration with certain drugs/foods ``` Folic Acid and Cyanocobalamin Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Ferrous sulfate- Oral Iron Products:
30
Liquid is commonly given through a straw or with Orange/Tomato juice to help absorption ``` Folic Acid and Cyanocobalamin Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Ferrous sulfate- Oral Iron Products:
31
Treatment of iron deficiency anemia ``` Folic Acid and Cyanocobalamin Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Parenteral Iron Products: Iron dextran
32
BOXED WARNING: anaphylactic reactions during any dose! ``` Folic Acid and Cyanocobalamin Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Parenteral Iron Products: Iron dextran
33
only ? product requiring a small TEST dose first only? ``` Folic Acid and Cyanocobalamin Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Parenteral Iron Products: Iron dextran
34
Hypotension during administration- Monitor vitals ``` Folic Acid and Cyanocobalamin Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Parenteral Iron Products: Iron dextran
35
Not commonly done anymore but. ◦IM Route- Use Z-track technique ``` Folic Acid and Cyanocobalamin Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Parenteral Iron Products: Iron dextran
36
Use Z-track technique ``` Folic Acid and Cyanocobalamin Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Parenteral Iron Products: Iron dextran
37
Iron replenishment for the body when dietary is insufficient (or excessive loss has occurred) ``` Folic Acid and Cyanocobalamin Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Parenteral Iron Products: Iron dextran
38
Low hemoglobin and hematocrit ``` MIcrocytic anemia (small MCV) Macrocytic anemias (large MCV) Normocytic Anemia ```
Normocytic Anemia
39
Iron replenishment for the body when dietary is insufficient (or excessive loss has occurred) ``` Folic Acid and Cyanocobalamin Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Parenteral Iron Products: Iron dextran
40
Megaloblastic anemias (DNA issue) most common ``` MIcrocytic anemia (small MCV) Macrocytic anemias (large MCV) Normocytic Anemia ```
Macrocytic anemias (large MCV)
41
Vitamin B12 deficiency, folate deficiency ``` MIcrocytic anemia (small MCV) Macrocytic anemias (large MCV) Normocytic Anemia ```
Macrocytic anemias (large MCV)
42
Large MCV◦ Folate Deficiency, Pernicious Anemia Treatment ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Folic Acid (B9) and Cyanocobalamin (B12)
43
B9 = Cyanocobalamin Folic Acid
Folic Acid
44
B12= Cyanocobalamin Folic Acid
Cyanocobalamin
45
Folic acid deficiency resulting in Macrocytic Anemia ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Folic Acid (B9)
46
During pregnancy to prevent neural tube defects ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Folic Acid (B9)
47
Folic acid deficiency resulting in Macrocytic Anemia ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Folic Acid (B9) B Vitamins
48
During pregnancy to prevent neural tube defects ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Folic Acid (B9) B Vitamins
49
used for Chronic Alcohol, Methotrexate ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Folic Acid (B9) B Vitamins
50
Should not be used until actual cause of anemia is determined? ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Folic Acid (B9) B Vitamins
51
May mask symptoms of pernicious anemia? ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Folic Acid (B9) B Vitamins
52
Seizure meds often decrease ? levels ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Folic Acid (B9) B Vitamins
53
Used to treat pernicious anemia and other megaloblastic anemias ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Cyanocobalamin (B12) B Vitamins
54
Requires Intrinsic Factor for absorption ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Cyanocobalamin (B12) B Vitamins
55
Can be given IM, SC, orally, intranasallyLow risk for toxicity ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Cyanocobalamin (B12) B Vitamins
56
Low risk for toxicity ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Cyanocobalamin (B12) B Vitamins
57
Often times, patients cannot absorb via GI Tract. Common to see INJECTIONS (IM,SC) or even Intranasal ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Cyanocobalamin (B12) B Vitamins
58
White blood cell lineage- Granulocyte colony stimulating factor (G-CSF) Erythropoietin
Granulocyte colony stimulating factor (G-CSF)
59
Red blood cell lineage- Granulocyte colony stimulating factor (G-CSF) Erythropoietin
Erythropoietin
60
Release erythropoietin to stimulate RBCs in Bone Marrow Liver or Kidneys
Kidneys
61
Insufficient oxygen Liver or Kidneys
Kidneys
62
Anemia in CKD- Chronic kidney disease ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Epoetin alfa, Darbepoetin alfa: Erythropoietin Stimulating Agents (ESA’s)
63
Chemotherapy induced Anemia (requires REMS) ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Epoetin alfa, Darbepoetin alfa: Erythropoietin Stimulating Agents (ESA’s)
64
Goal is to increase the Hemoglobin and Hematrocit (H/H) ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Epoetin alfa, Darbepoetin alfa: Erythropoietin Stimulating Agents (ESA’s)
65
You should observe an H/H increase ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Epoetin alfa, Darbepoetin alfa: Erythropoietin Stimulating Agents (ESA’s)
66
Erythropoietin Stimulating Agents (ESA’s): Epoetin alfa, Darbepoetin alfa The goal cut off is Hgb of ? gm/dL◦Higher than this increases risk of adverse effects
11 gm/dL
67
HYPERTENSION (most common)◦Heart Attack, Stroke, Heart Failure, thrombosis, seizure ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Epoetin alfa, Darbepoetin alfa: Erythropoietin Stimulating Agents (ESA’s)
68
Blood Clots (DVTs/PEs) ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Epoetin alfa, Darbepoetin alfa: Erythropoietin Stimulating Agents (ESA’s)
69
Went from low H/H (“thin blood”) to increased H/H (“thickened the blood”) ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Epoetin alfa, Darbepoetin alfa: Erythropoietin Stimulating Agents (ESA’s)
70
Contraindications: drug allergy, uncontrolled hypertension, head and neck cancers, risk of thrombosis ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Epoetin alfa, Darbepoetin alfa: Erythropoietin Stimulating Agents (ESA’s)
71
BOXED WARNING: ESA’s: Epoetin Alfa ``` DIABITIES CANCER CHRONIC KIDNEY DISEASE SJS CARDIOVASCULAR SULFUR ```
CANCER CHRONIC KIDNEY DISEASE CARDIOVASCULAR
72
Boxed Warning CANCER CHRONIC KIDNEY DISEASE CARDIOVASCULAR
Epoetin alfa, Darbepoetin alfa: Erythropoietin Stimulating Agents (ESA’s)
73
Monitor blood pressure PRIOR TO ADMINISTRATION and frequently (risk for stroke, MI) ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Epoetin alfa, Darbepoetin alfa: Erythropoietin Stimulating Agents (ESA’s)
74
Monitor hemoglobin levels (>11 g/dL) PRIOR TO ADMINISTATION (increases risk for thrombotic event and BP event) ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Epoetin alfa, Darbepoetin alfa: Erythropoietin Stimulating Agents (ESA’s)
75
Patients should report body aches, headaches ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Epoetin alfa, Darbepoetin alfa: Erythropoietin Stimulating Agents (ESA’s)
76
ADMINISTRATION: Single Use Vial ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Epoetin alfa, Darbepoetin alfa: Erythropoietin Stimulating Agents (ESA’s)
77
Do NOT shake/agitate ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Epoetin alfa, Darbepoetin alfa: Erythropoietin Stimulating Agents (ESA’s)
78
One time use, don’t use vial for multiple doses ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Epoetin alfa, Darbepoetin alfa: Erythropoietin Stimulating Agents (ESA’s)
79
IV (Dialysis) SC (on the Unit) ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Epoetin alfa, Darbepoetin alfa: Erythropoietin Stimulating Agents (ESA’s)
80
Stimulates production of RBC's in the bone marrow. Natural hormone is produced by the kidneys ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Epoetin alfa, Darbepoetin alfa: Erythropoietin Stimulating Agents (ESA’s)
81
Do not give if active tumor (head/neck) can cause tumor progression ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Epoetin alfa, Darbepoetin alfa: Erythropoietin Stimulating Agents (ESA’s)
82
Severe Chronic Neutropenia ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Filgrastim (Neupogen®) - G-CSF’s
83
Chemotherapy induced Neutropenia ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Filgrastim (Neupogen®) - G-CSF’s
84
Many other uses pertaining to stem cells/bone marrow transplants ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Filgrastim (Neupogen®) - G-CSF’s
85
``` ADVERSE EFFECTS- Bone pain (25% of patients) ``` ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Filgrastim (Neupogen®) - G-CSF’s
86
Leukocytosis- excessive production- very rare, but this controlled by monitoring CBC’s frequently ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Filgrastim (Neupogen®) - G-CSF’s
87
Monitor CBC twice weekly (WBC/ANC) ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Filgrastim (Neupogen®) - G-CSF’s
88
CSF: Filgrastim | HOLD IF WBC > ? , ANC > ?
10,000 | 1,500
89
Patients should report body aches (bone pain), can treat pain if needed (acetaminophen or opioids) ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Filgrastim (Neupogen®) - G-CSF’s
90
IM/SC- DO NOT SHAKE VIALS! Discard after one usage- Not reusable ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Filgrastim (Neupogen®) - G-CSF’s
91
Essentially identical to human granulocyte colony-stimulating factor ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Filgrastim (Neupogen®) - G-CSF’s
92
Ad SE Bone pain ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Filgrastim (Neupogen®) - G-CSF’s
93
Leukocytosis ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Filgrastim (Neupogen®) - G-CSF’s
94
splenomegaly ``` Folic Acid (B9) Cyanocobalamin (B12) Epoetin alfa (Epogen®) Darbepoetin alfa Iron dextran (INFed®) Ferrous sulfate Filgrastim (Neupogen®) Sargramostim ```
Filgrastim (Neupogen®) - G-CSF’s

Phamacology (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions