Antiepileptics Flashcards
Anti-Epilepsy Drugs (AED’s) TRADITIONAL Lamotrigine Carbamazepine Phenobarbital/Primidone Gabapentin Phenytoin/Fosphenytoin Levetiracetam Valproic Acid/Valproate/Divalproex sodium Topiramate Pregabalin Lacosamide Lorazepam/Diazepam Oxcarbazepine
Phenytoin/Fosphenytoin Carbamazepine Valproic Acid/Valproate/Divalproex sodium Lorazepam/Diazepam Phenobarbital/Primidone
Anti-Epilepsy Drugs (AED’s) New Lamotrigine Carbamazepine Phenobarbital/Primidone Gabapentin Phenytoin/Fosphenytoin Levetiracetam Valproic Acid/Valproate/Divalproex sodium Topiramate Pregabalin Lacosamide Lorazepam/Diazepam Oxcarbazepine
Lamotrigine Gabapentin Topiramate Pregabalin Oxcarbazepine Lacosamide Levetiracetam
Higher risk for developing fetus Hepatic enzyme involvement (drug-drug!) More sedative, adverse effects? Lamotrigine Carbamazepine Phenobarbital/Primidone Gabapentin Phenytoin/Fosphenytoin Levetiracetam Valproic Acid/Valproate/Divalproex sodium Lorazepam/Diazepam Topiramate Pregabalin Lacosamide Lorazepam/Diazepam Oxcarbazepine
Traditional Carbamazepine Phenobarbital/Primidone Phenytoin/Fosphenytoin Valproic Acid/Valproate/Divalproex sodium Lorazepam/Diazepam
May have less risk for developing fetus Less drug-drug interactions Lamotrigine Carbamazepine Phenobarbital/Primidone Gabapentin Phenytoin/Fosphenytoin Levetiracetam Valproic Acid/Valproate/Divalproex sodium Topiramate Pregabalin Lacosamide Lorazepam/Diazepam Oxcarbazepine
New Lamotrigine Gabapentin Levetiracetam Topiramate Pregabalin Oxcarbazepine
Treat: All types of seizures Drug of choice in adults and older children Lamotrigine Carbamazepine Phenobarbital/Primidone Gabapentin Phenytoin/Fosphenytoin Levetiracetam Valproic Acid/Valproate/Divalproex sodium Topiramate Pregabalin Lacosamide Lorazepam/Diazepam Oxcarbazepine
Traditional
Phenytoin/Fosphenytoin
Treats Status epilepticus Lamotrigine Carbamazepine Phenobarbital/Primidone Gabapentin Phenytoin/Fosphenytoin Levetiracetam Valproic Acid/Valproate/Divalproex sodium Topiramate Pregabalin Lacosamide Lorazepam/Diazepam Oxcarbazepine
Traditional
Phenytoin/Fosphenytoin
NO LONGER used as a drug for cardiac dysrhythmias Lamotrigine Carbamazepine Phenobarbital/Primidone Gabapentin Phenytoin/Fosphenytoin Levetiracetam Valproic Acid/Valproate/Divalproex sodium Topiramate Pregabalin Lacosamide Lorazepam/Diazepam Oxcarbazepine
Traditional
Phenytoin/Fosphenytoin
MECHANISM OF ACTION selective inhibition of sodium channels Lamotrigine Carbamazepine Phenobarbital/Primidone Gabapentin Phenytoin/Fosphenytoin Levetiracetam Valproic Acid/Valproate/Divalproex sodium Topiramate Pregabalin Lacosamide Lorazepam/Diazepam Oxcarbazepine
Traditional
Phenytoin/Fosphenytoin
Treat: Seizures, Bipolar disorder, Trigeminal and glossopharyngeal neuralgias Lamotrigine Carbamazepine Phenobarbital/Primidone Gabapentin Phenytoin/Fosphenytoin Levetiracetam Valproic Acid/Valproate/Divalproex sodium Topiramate Pregabalin Lacosamide Lorazepam/Diazepam Oxcarbazepine
Tradition
Carbamazepine
MECHANISM OF ACTION
Blockade of Na+, Stimulates the release of ADH
Tradition
Carbamazepine
Treat:
Epilepsy – useful against all types of seizures, Bipolar disorder, & Migraine prevention
Lamotrigine Carbamazepine Phenobarbital/Primidone Gabapentin Phenytoin/Fosphenytoin Levetiracetam Valproic Acid/Valproate/Divalproex sodium Topiramate Pregabalin Lacosamide Lorazepam/Diazepam Oxcarbazepine
Traditional
Valproic Acid
MECHANISM OF ACTION
Blockade of Na+, Ca++ channels AND may potentiate effects of GABA
Traditional
Valproic Acid
Treat:
Anxiety (Generalized Anxiety Disorder, GAD)
Insomnia
Seizure Disorders
Muscle Spasms
Alcohol Withdrawal
Peri-Operative (anesthesia, conscious sedation)
Traditional
Benzodiazepine
MECHANISM OF ACTION
Potentiate/amplifies the actions of GABA (gamma-amino-butyric acid), does NOT directly mimic GABA
Traditional
Benzodiazepine
Nursing Considerations Which Benzo commonly used for STATUS EPILEPTICUS Midazolam Lorazepam Temazepam Diazepam Chlordiazepoxide
Lorazepam and Diazepam
Treat:
Seizures
Sedatives
off label for alcohol withdrawal
Traditional Barbiturates
phenobarbital +primidone
MECHANISM OF ACTION
Potentiate/amplifies the actions of GABA (gamma-amino-butyric acid), and directly mimic GABA (prolongs duration of chloride channel opening)
Traditional Barbiturates
phenobarbital +primidone
Which barbiturate is used for STATUS EPILEPTICUS?
Methohexital
Phenobarbital
Primidone
Phenobarbital
Benzo and Barbiturates are Classified as Traditional, but not quite the same risk profile?
True or False
True
Which has the Gingival Hyperplasia (20% patients, folic acid supplementation and good oral hygiene)
Lamotrigine Carbamazepine Phenobarbital/Primidone Gabapentin Phenytoin/Fosphenytoin Levetiracetam Valproic Acid/Valproate/Divalproex sodium Topiramate Pregabalin Lacosamide Lorazepam/Diazepam Oxcarbazepine
Traditional
Phenytoin/Fosphenytoin
Traditional
Phenobarbital/Primidone
BOXED WARNING
Too rapid infusion can cause dysrhythmias/hypotension, No faster than ? mg/min
50
Hirsutism, Skin Rash,
Lamotrigine Carbamazepine Phenobarbital/Primidone Gabapentin Phenytoin/Fosphenytoin Levetiracetam Valproic Acid/Valproate/Divalproex sodium Topiramate Pregabalin Lacosamide Lorazepam/Diazepam Oxcarbazepine
Traditional
Phenytoin/Fosphenytoin
SJS/TEN◦
Preliminary Data- Severe Rash- HLA-B1502 allele10% higher risk for SJS/TEN
Lamotrigine Carbamazepine Phenobarbital/Primidone Gabapentin Phenytoin/Fosphenytoin Levetiracetam Valproic Acid/Valproate/Divalproex sodium Topiramate Pregabalin Lacosamide Lorazepam/Diazepam Oxcarbazepine
Traditional
Phenytoin/Fosphenytoin
Traditional Antiepileptics
Carbamazepine
Traditional
Phenytoin/Fosphenytoin
Incresed or Decreased levels of Vit K/D,
Decreased
HLA-B*1502 allele
Lamotrigine Carbamazepine Phenobarbital/Primidone Gabapentin Phenytoin/Fosphenytoin Levetiracetam Valproic Acid/Valproate/Divalproex sodium Topiramate Pregabalin Lacosamide Lorazepam/Diazepam Oxcarbazepine
Traditional Antiepileptics
Phenytoin/Fosphenytoin
Traditional Antiepileptics
Carbamazepine
Traditional
Phenytoin/Fosphenytoin
Narrow Therapeutic Index
? - ?mcg/mL
10-20
Toxic symptoms/ montor : Nystagmus, Ataxia, diplopia, drowsiness, sedation
Lamotrigine Carbamazepine Phenobarbital/Primidone Gabapentin Phenytoin/Fosphenytoin Levetiracetam Valproic Acid/Valproate/Divalproex sodium Topiramate Pregabalin Lacosamide Lorazepam/Diazepam Oxcarbazepine
Traditional
Phenytoin/Fosphenytoin
Carbamazepine
C. Valproic Acid
ENZYME INDUCER- renders OC’s ineffective
Lamotrigine Carbamazepine Phenobarbital/Primidone Gabapentin Phenytoin/Fosphenytoin Levetiracetam Valproic Acid/Valproate/Divalproex sodium Topiramate Pregabalin Lacosamide Lorazepam/Diazepam Oxcarbazepine
Traditional
Phenytoin/Fosphenytoin
Administration
DILUTE IV AND GIVE AS A SLOW IV PUSH (no faster than 50 mg/min) to reduce BP and cardiovascular risks
Traditional
Phenytoin/Fosphenytoin
Teratogenic!-Pregnancy Category D
Lamotrigine Carbamazepine Phenobarbital/Primidone Gabapentin Phenytoin/Fosphenytoin Levetiracetam Valproic Acid/Valproate/Divalproex sodium Topiramate Pregabalin Lacosamide Lorazepam/Diazepam Oxcarbazepine
Traditional
Phenytoin/Fosphenytoin
Carbamazepine
C. Valproic Acid
Bone marrow suppression that leads to hematological effects- Aplastic anemia and agranulocytosis
Lamotrigine Carbamazepine Phenobarbital/Primidone Gabapentin Phenytoin/Fosphenytoin Levetiracetam Valproic Acid/Valproate/Divalproex sodium Topiramate Pregabalin Lacosamide Lorazepam/Diazepam Oxcarbazepine
Traditional Antiepileptics
Carbamazepine
Aplastic anemia and agranulocytosis
Lamotrigine Carbamazepine Phenobarbital/Primidone Gabapentin Phenytoin/Fosphenytoin Levetiracetam Valproic Acid/Valproate/Divalproex sodium Topiramate Pregabalin Lacosamide Lorazepam/Diazepam Oxcarbazepine
Traditional Antiepileptics
Carbamazepine
Promotes ADH (water) - can cause fluid retention
Lamotrigine Carbamazepine Phenobarbital/Primidone Gabapentin Phenytoin/Fosphenytoin Levetiracetam Valproic Acid/Valproate/Divalproex sodium Topiramate Pregabalin Lacosamide Lorazepam/Diazepam Oxcarbazepine
Traditional Antiepileptics
Carbamazepine
LIVER ENZYME INDUCE: : Oral Contraceptives, Warfarin
Traditional Antiepileptics
Carbamazepine
Teratogenic- Pregnancy Category D
Risk is 4 times greater than other AEDs
Traditional Antiepileptics
Valproic Acid
BOXED WARNING: Hepatotoxicity
Lamotrigine Carbamazepine Phenobarbital/Primidone Gabapentin Phenytoin/Fosphenytoin Levetiracetam Valproic Acid/Valproate/Divalproex sodium Topiramate Pregabalin Lacosamide Lorazepam/Diazepam Oxcarbazepine
Traditional Antiepileptics
Valproic Acid
BOXED WARNING: Pancreatitis
Traditional Antiepileptics
Valproic Acid
BOXED WARNING: Fetal Harm
Traditional Antiepileptics
Valproic Acid
BOXED WARNING: patient with mitochondrial disease increased risk for liver failure.
mitochondrial DNA polymerase gamma (POLG) gene (Alpers-Huttenlocher syndrome)
Lamotrigine Carbamazepine Phenobarbital/Primidone Gabapentin Phenytoin/Fosphenytoin Levetiracetam Valproic Acid/Valproate/Divalproex sodium Topiramate Pregabalin Lacosamide Lorazepam/Diazepam Oxcarbazepine
Traditional Antiepileptics
Valproic Acid
Avoid Drugs like Phenytoin that cause SJS/TEN- Allopurinol, Carbamazepine, Lamotrigine, Phenobarbital
Traditional
Phenytoin/Fosphenytoin
Carbamazepine
Cleft lip/palates
Traditional
Phenytoin/Fosphenytoin
Long term usage- Osteoporosis
Traditional
Phenytoin/Fosphenytoin
Spina Bifida, & Cleft Palate
Traditional Antiepileptics
Valproic Acid
HPR- High pregnancy Risk
H- Hepatotoxicity, R- Rash skin, P- Pregnancy risk/ Pancreatitis/ Platelets
Traditional Antiepileptics
Valproic Acid
Traditional Antiepileptics Valproic Acid HPR- H- R- P-
High pregnancy Risk
Hepatotoxicity
Rash skin
Pregnancy risk/ Pancreatitis/ Platelets
NC
Hepatotoxicty + Pancreatitis: Monitor LFTs + amylase periodically, patient should also monitor for N/V, jaundice, abdominal pain
Traditional Antiepileptics
Valproic Acid
NC
Rarely Thrombocytopenia: Monitor platelets, educate patient to notify prescriber of bruising
Traditional Antiepileptics
Valproic Acid
Administration
Give with Food
Lamotrigine Carbamazepine Phenobarbital/Primidone Gabapentin Phenytoin/Fosphenytoin Levetiracetam Valproic Acid/Valproate/Divalproex sodium Topiramate Pregabalin Lacosamide Lorazepam/Diazepam Oxcarbazepine
Traditional Antiepileptics
Valproic Acid
Carbamazepine
Mnemonic CBS C- Check labs! (CBC/BMP), B- Blood dyscrasia (pancytopenia), S- Skin Rash
Traditional Antiepileptics
Carbamazepine
Traditional Antiepileptics Carbamazepine CBS C- B- S-
Check labs! (CBC/BMP),
Blood dyscrasia (pancytopenia),
Skin Rash
Nursing Considerations
Due to bone marrow suppression
Periodic checks of CBC—- Report fever/sore throat
Traditional Antiepileptics
Carbamazepine
Fluid Retention Check BMP (Blood Metabolic Panel) (Na, BUN)
Traditional Antiepileptics
Carbamazepine
CNS effects
Use caution when driving,
The visual disturbances should decrease over time
Traditional Antiepileptics
Carbamazepine
Due to SJS/TEN HLA-B*1502
Protect skin from sun exposure
Traditional Antiepileptics
Carbamazepine
Traditional
Phenytoin/Fosphenytoin
Gingival Hyperplasia
Periodic dental visits, Brush teeth with soft bristle toothbrush, floss, massage gums
Traditional
Phenytoin/Fosphenytoin
Teratogenic- Do not use in pregnancy
renders OC’s ineffective
Traditional
Phenytoin/Fosphenytoin
CNS Sedation- Do not drive or operate heavy machinery if experiencing CNS depression
Traditional
Phenytoin/Fosphenytoin
ENZYME INDUCER- renders OC’s ineffective
Traditional
Phenytoin/Fosphenytoin
Administration- Slow IV (50 mg/min
Traditional
Phenytoin/Fosphenytoin
LIVER ENZYME INDUCE: : Oral Contraceptives, Warfarin
Traditional
Phenytoin/Fosphenytoin
Which drugs causes SJS/TEN reactions Allopurinol Carbamazepine Lamotrigine Phenobarbital
Alll
Treat:
Epilepsy
BiPolar Disorder
New Antiepileptics
Lamotrigine
ADVERSE EFFECTS
Serious Skin Rashes (SJS/TEN)
Pregnancy Category C–Cleft Lip/Palate
New Antiepileptics
Lamotrigine
Pregnancy Category C–Cleft Lip/Palate
New Antiepileptics
Lamotrigine
Treat:
Epilepsy, Migraines/Cluster Headaches, Off label: weight loss
Lamotrigine Carbamazepine Phenobarbital/Primidone Gabapentin Phenytoin/Fosphenytoin Levetiracetam Valproic Acid/Valproate/Divalproex sodium Topiramate Pregabalin Lacosamide Lorazepam/Diazepam Oxcarbazepine
New Antipileptics
Topiramate
ADVERSE EFFECTS
Weight loss/anorexia
Some patients report 10 kg + Patients may experience reduced sweating/ increased body temperature (be careful with exercise!)
New Antiepileptics
Topiramate
CNS- somnolence, dizziness, diplopia
New Antipileptics
Topiramate
Treat:
Post herpetic Neuralgia
Diabetic Neuropathy
Lamotrigine Carbamazepine Phenobarbital/Primidone Gabapentin Phenytoin/Fosphenytoin Levetiracetam Valproic Acid/Valproate/Divalproex sodium Topiramate Pregabalin Lacosamide Lorazepam/Diazepam Oxcarbazepine
New Antiepileptics
Gabapentin
ADVERSE EFFECTS
Peripheral Edema
Lamotrigine Carbamazepine Phenobarbital/Primidone Gabapentin Phenytoin/Fosphenytoin Levetiracetam Valproic Acid/Valproate/Divalproex sodium Topiramate Pregabalin Lacosamide Lorazepam/Diazepam Oxcarbazepine
New Antiepileptics
Gabapentin