Chemotherapy and Radiotherapy in Gynaecalogical Cancers Flashcards
A women presents with early satiety, abdominal distension and pain. How long and how often would these symptoms have to had been occuring for in order for a diagnosis of ovarian cancer to be considered?
Less than 12 months duration more than 12 times a month
What would be classed a suspicious findings on ovarian US?
Multilocular cyst Solid areas Bilateral lesions Ascites Intra abdominal metastases
What is the % 5 year survival for a women with stage 1 ovarian cancer?
80 - 90%
What is the % 5 year survival for a women with stage 2 ovarian cancer?
65%
What is the % 5 year survival for a women with stage 3 ovarian cancer?
15 - 35%
What is the % 5 year survival for a women with stage 4 ovarian cancer?
Up to 15%
What is the first line chemotheraputic agent given in ovarian cancer when there is curative intent?
Paclitaxel
What is the first line chemotheraputic agent in advanced ovarian cancer?
Carboplatin
What % of ovarian tumours respond to tamoxifen?
10%
How is ovarian cancer staged?
Midline laporotomy with assessment of the peritoneal surface.
Total abdominal hysterectomy, bilateral salpingoophrectomy and infracolic omentectomy with retroperitoneal lymph node assessment.
Close inspection of the liver, spleen, peritoneum etc
Discuss the surgery is early ovarian cancer
Debulking surgery
Peritoneal cytology, hysterectomy, removal of the ovaries and fallopian tubes and infracolic omentectomy
What is the current chemotherapy regime in ovarian cancer?
Carboplatin and Paclitaxel given for 6 cycles at three weekly intervals.
A women undergoing chemotherapy for ovarian cancer loses her hair. Which drug will be causing this?
Paclitaxel. Carboplatin doesn’t cause alopecia.
Which chemotheraputic agent, used in ovarian cancer, causes peripheral sensory neuropathy?
Paclitaxel
Which chemotheraputic agent, used in ovarian cancer, causes joint pain? When does this usually occur?
Paclitaxel. 3 days after treatment
