Chemoreception of CO2

Question 1

What is a chemoreceptor?

Answer 1

Receptor that responds to a chemical change in the composition of blood or other fluid surrounding it

Question 2

what are the two classes of chemoreceptors?

Answer 2

Central and peripheral

Question 3

What is the afferent relay system for the periphery?

Answer 3

NTS

Question 4

Where are central chemoreceptors found?

Answer 4

NTS
VLM
VRG
RTN
caudal raphe
Locus coeruleus (pons)

Question 5

Where is CO2 sensing completed?

Answer 5

Astrocytes

Question 6

What is the PCO2 and pH of CSF?

Answer 6

PCO2 = 50mmhg
pH = 7.32

Question 7

What is a nexus in central CO2 chemosensitivity?

Answer 7

RTN

Question 8

What makes the decision to breathe?

Answer 8

RTN

Question 9

How does a chemoreceptor discharge?

Answer 9

If intracellular pH drops caused by the influx of hydrogen ions

Question 10

What do central chemoreceptors respond to?

Answer 10

Intracellular acidosis

Question 11

What is the relationship between the firing rate of CCs and CO2 concentration?

Answer 11

Directly proportional - linear

Question 12

What responds to hypercapnia in the periphery?

Answer 12

Carotid bodies

Question 13

What kind of response is the carotid bodies’ to changes in PaCO2?

Answer 13

Rapid and linear

Question 14

What is hypercapnia caused by?

Answer 14

Lung disease
Hypoventilation

Question 15

What causes respiratory acidosis?

Answer 15

Alveolar hypoventilation

Question 16

What causes respiratory alkalosis?

Answer 16

Alveolar hyperventilation

Question 17

What do peripheral chemosensors sense?

Answer 17

Changes in PaCO2 and PaO2