chemo + mucositits Flashcards
what is the mechanism of action of chemo
target processes that cancer cells have expolited
- rapid prolife = syntheiss
altered metabolism, hypxia tolerance, loss of checkpoint inhibition
resistance to apoptosis
which cells are more at risk in checmo
non specific = targets rapdily dividing cells
= epithelium GIT, hair follicles, bone marrow
what is mucositis
inflam of mucosa
burning /tingling
atrophy squamous epi, vas damage, inflam infiltrate, ulceration
,oith, GI, airway
describe properties of the oral mucosa
strat aquamous epi + lamina propria, coneccted to basal ganglia
hard palate, ginfigva, mucosa tongue = keratinised
dscribe protective function of oral mucosa
separates + protects depper tissues + rogans from env oral cavity
abrasions + mech forces
bassrier from microbes
describe sensation and secretion of oral mucosa
temo touch m pain,m taste, reflexes, salive, (lubem taste, anti-microbial)
describe inititation of patho in mucositis
ROS, damage to cells, tissues, bc
describe upregulation + message gen in patho of mucositis
simultaneous bio events in al tissues + levels
describe signalling + amp in patho mucositis
bio cross talk + amp
generaltised alteration of mucosal env
appearnaces deceiving
descibe ulceration of patho mucositits
bacterial colonisation
cytokine amp
inflam ‘pain
bacteramia/sepsis
describe healing in matho of mucositsi
Intact epithelium • Tissue “appears” normal • Residual angiogenesis • The tissue you start with is NOT the tissue you end with
treatment =
5- fluracil = s phase = high risk of developing severe oral mucositis
recommends 30 mins oral cryotherapy to prevent mucositis bc = short life, cost effective, poor adherence bc can’t tolerate
instead = prevention with mesenchymal stem cells
