Chapter 9B Flashcards
gastric phase (the end)
The pH of the stomach chyme in/decreases and the distension of
the stomach walls lessens because chyme
has passed into the small intestine,
suppressing secretion of gastric juice
(positive/negative feedback loop)
decreases, negative
HORMONAL REGULATION: gastric secre>on during the gastric phase is regulated by the
hormone X
gastrin
Gastrin is released from the X cells
of the gastric glands in response to:
- distension of the stomach by
chyme - partially/fully digested proteins in
chyme - low/high pH of chyme
- caffeine in gastric chyme
- acetylcholine released from
parasympathetic/sympathetic neurons
- Once released, gastrin enters the
bloodstream and finally reaches its
target organs in the digestive system
G cells
partially
high
Gastrin functions:
- stimulates gastric glands to
secrete gastric juice - strengthens the contraction of the
X sphincter to
prevent reflux of acid chyme into
the esophagus - promotes gastric emptying by
increasing motiity of the stomach
and relaxing the pyloric sphincter
lower esophageal
Gastrin secretion is inhibited when the
pH of gastric juice drops below/rises above 2.0 and
is stimulated when the pH decreases/rises.
drops below
rises
Intestinal phase:
* It begins once food enters the small intestine.
* In contrast to reflexes initiated during the cephalic and gastric phases, which
stimulate stomach secretory activity and motility, those occurring during the
intestinal phase have inhibitory effects that slow X
the exit of chyme from the
stomach. This prevents the duodenum from
being overloaded with more chyme
than it can handle.
These activities of the intestinal phase
of digestion are regulated by X and X mechanisms.
NEURAL
and HORMONAL
Distension of the duodenum by
the presence of chyme causes
the X reflex.
- Stretch receptors in the
duodenal wall send nerve
impulses to the medulla
oblongata, where they inhibit
parasympathetic stimulation
and stimulate the sympathetic
nerves to the stomach. - As a result, ……..
enterogastric
gastric motility is inhibited and there is an
increase in the contraction of the pyloric sphincter, which decreases gastric emptying.
HORMONAL REGULATION: The intestinal phase of digestion is mediated by two
major hormones secreted by the small intestine:
- Cholecystokinin (CCK): is
secreted by the CCK cells of
intestinal glands in the small
intestine in response to chyme
containing X and X - Secretin: is released from the S
cells of the intestinal glands in
the small intestine in response
to X entering the
duodenum .
amino acids from
partially digested proteins and
fatty acids from partially
digested triglycerides.
acidic chyme
- Functions of CCK:
1. produces hunger/satiety (acts on
hypothalamus)
2. slows/rapids gastric emptying by promoting
contraction of the pyloric sphincter
3. stimulates secretion of pancreatic
juice (rich in digestive enzymes)
4. promotes normal growth and
maintenance of the pancreas
5. contraction of the wall of the
gallbladder (squeezes stored bile out)
6. relaxation of hepatopancreatic
ampulla sphincter (Oddi sphincter)
allowing pancrea2c juice and bile to
flow into the duodenum
7. enhances the effects of secre2n
satiety
slows
Functions of secretin:
- stimulates the flow of
X juice that is rich in
bicarbonate (HCO3 −) ions to
buffer the acidic chyme that
enters the duodenum from the
stomach - inhibits secretion of X
juice (slows production of acid
in the stomach) - promotes normal growth and
maintenance of the pancreas - enhances the effects of CCK
pancreatic
gastric
The opening from the ileum into the large intestine is guarded by a fold of mucous
membrane called the X (valve), which allows materials from the
small intestine to pass into the large intestine.
ileocecal sphincter
Structurally, the four
major regions of the
large intestine are:
Rectum
Cecum
Anal canal
Colon
put in right order
- Cecum
- Colon (ascending,
transverse and
descending) - Rectum
- Anal canal
The opening of the anal canal to the
exterior (anus), is guarded by:
* Internal anal sphincter of
smooth muscle (involuntary)
and
* External anal sphincter of
skeletal muscle (voluntary).
* These sphincters keep the anus
closed except during the elimination
of feces.
ok
Large intestine:
The epithelium contains mostly X cells (water absorption) and goblet cells
(secrete mucus that lubricates)
- Both cells are located in long, straight, tubular intestinal glands (crypts of
X) that extend the full thickness of the mucosa. - Solitary lympha>c nodules are also found.
- Large intes>ne does not have circular folds or villi; however, microvilli are present on
the absorp>ve cells.
absorptive
Lieberkühn