Chapter 9: Blood, Lymphatic, & Immune Systems Flashcards
Responsibility of the Blood:
Responsible for transporting O2/CO2 and provide cells that fight against disease. Also protects the body from blood loss by the action of clotting.
Responsibility of the Lymphatic System:
Responsible for cell communication by delivering nutrients, hormones, and other needed products to body cells while removing their waste. Also provides cells of the immune system to fight diseases.
Responsibility of the Immune System:
Defend the body against disease.
Define antibody:
Protective protein produced by B lymphocytes in response to the presence of specific foreign antigens; combine with antigens to destroy or neutralize them.
Define antigen:
Substance, recognized as harmful to the host, that stimulates formation of antibodies in an immunocompetent individual.
Define bile pigment:
Substance derived from the breakdown of hemoglobin and excreted by the liver. Interference of excretion of bile may cause jaundice.
Define cytokine:
Chemical substance produced by certain cells that initiates, inhibits, increases, or decreases activity in other cells. These are important chemical communicators in immune response, regulating many activities associated with immunity and inflammation.
Define dendritic cell:
Specialized type of monocyte that displays antigens on its cell surface and presents them to the components of the immune system.
Define immunocompetent:
Possessing the ability to develop an immune response.
Define natural killer (NK) cells:
Specialized lymphocytes that destroy virally infected cells and tumor cells by releasing chemicals that disrupt their cell membranes, causing their intracellular fluid to leak out. These are components of the innate immune system and do not require prior sensitization to engage in cell destruction.
What is blood?
Connective tissue composed of a liquid medium called plasma, in which solid components are suspended. Formed in the bone marrow; stem cells in the bone marrow give rise to blastic forms of all types of blood cells. Once the blood cells mature, they enter the circulatory system.
Medical word for RBC:
erythrocyte
Medical word for WBC:
leukocyte
Medical word for platelet:
thrombocyte
Define blastic
embryonic
Define hematopoiesis or hemopoiesis
Development of blood cells into their mature forms.
Tell me about RBCs
Also called erythrocytes; function is to transport O2/CO2, and they’re the most numerous type of blood cell. Mature RBCs are shaped like biconcave discs, because they extrude their nuclei just before maturation. They develop Hgb that gives them their red color, and they live ~120 days before they rupture.
hemoglobin, Hb, Hgb
Specialized, iron-containing compound on RBCs that give them their red color.
Hemosiderin
Product of broken down Hgb that returns to the bone marrow for reuse in a different form to manufacture new blood cells.
Tell me about WBCs
Also called leukocytes, these protect the body against foreign pathogens and substances. These are essential to the healing process, because they can perform phagocytosis. They also perform diapedesis, and are divided into granulocytes and agranulocytes.
What’s phagocytosis?
Ingestion and destruction of bacteria and other foreign particles.
What’s diapedesis?
Migration through the endothelial walls of capillaries and venules to enter tissue spaces.
Define granulocytes
Also called polymorphonuclear leukocytes (PMNLs); WBCs that have granules present in their cytoplasm. These are further classified according to the staining reaction of their granules during preparation for blood smears.
Neutrophils
Eosinophils
Basophils
Neutrophils
1) Granules appear lilac color.
2) First cells to arrive at the site of an injury.
3) Provides non-specific protection via phagocytosis; dies as a result of this.
Eosinophils
1) Granules appear a red color.
2) Combats multicellular parasites (worm infections).
3) Controls mechanisms associated with allergies.
Basophils
1) Granules appear purple color.
2) Initiates inflammation.
Polymorphonuclear leukocytes (PMNLs)
Another name for granulocytes; called this because their nuclei are so deeply lobed that they appear to have multiple nuclei.
Define agranulocytes:
Leukocytes that have an absence of granules in their cytoplasm; also called mononuclear leukocytes (MNLs). Separated into lymphocytes and monocytes.
Lymphocytes
1) Agranular
2) Provides acquired (specific) immunity
Monocytes
1) Agranular
2) Performs a mildly phagocytic function.
3) Becomes a macrophage when it enters tissues and functions in immunity.
Tell me about platelets:
Also called thrombocytes; smallest formed element found in the blood. These aren’t true cells, but merely cell fragments, and they initiate blood clotting.
Thromboplastin
A substance that initiates clot formation that’s released by platelets.
Fibrinogen
A soluble blood protein that becomes insoluble to form fibrin strands and act as a net to stop bleeding.
Thrombus, blood clot
A jelly-like mass of blood cells and fibrin that impedes the flow of blood into surrounding tissues.
Tell me about plasma:
Thin, colorless fluid that makes up the liquid portion of blood. Small amounts of plasma continually leak from capillaries into surrounding tissues to deliver nutrients and exchange for wastes, which makes communication between cells possible.
Blood serum
Product of blood plasma formed when fibrinogen and clotting factors are removed from the plasma.
What are the 4 human blood types?
A, B, AB, and O.
What is the lymphatic system?
Consists of a fluid called lymph, and contains lymphocytes, monocytes, lymph vessels, nodes, the spleen, the thymus, and the tonsils.
Functions of the lymphatic system:
1) Maintain fluid balance in the body by draining interstitial fluid from tissue spaces and returning it to the blood.
2) Transports lipids away from digestive organs for use by body tissues.
3) Filters and removes unwanted or infectious products in lymph nodes.
2 ducts of the lymphatic system:
1) Right lymphatic duct: drains fluid from the right chest/arm and head. Drains into the right subclavian vein.
2) Thoracic duct: Drains fluid from the rest of the body. Drains into the left subclavian vein..
How does the lymphatic system work?
1) As blood circulates, a small amount of plasma seeps from the capillaries into the surrounding tissue.
2) Interstitial fluid carries needed products to tissues and removes their wastes.
3) Upon completion, the fluid either returns to the circulatory system as plasma, or enters lymph capillaries to form lymph fluid.
4) Enters lymph nodes where macrophages phagocytize bacteria and T and B cells exert their protective influence.
5) Once filtered, lymph exits the node through efferent vessels and eventually makes its way back to the circulatory system.
Lymph capillaries
Closed-ended microscopic vessels of the lymphatic system.
Tell me about the Spleen:
Resembles a lymph node, because it acts as a filter by removing cell debris, bacteria, and parasites. Also destroys old RBCs and acts as a repository for healthy blood cells.
Tell me about the thymus:
Located in the mediastinum and controls the immune system by transforming certain lymphocytes into T cells to function in the immune system.
Tell me about the tonsils:
Masses of lymphatic tissue located in the pharynx that act as filters to protect the upper respiratory structures from invasion by pathogens.
Function of the immune system:
Protect the body from pathogens.
Innate (nonspecific) Immunity:
Includes barriers designed to keep pathogens from entering the body, and is called innate because it’s present from the very beginning of life. This system doesn’t differentiate specific types of pathogens
Define Immunity:
Collection of numerous body defenses that work together to protect against diseases.
Acquired (specific) immunity:
Also called adaptive immunity, and only develops after birth in an immunocompetent individual. This is a lifelong monitoring system; produces unique cells and processes that destroy particular cells. WBCs responsible for this are lymphocytes and monocytes.
Monocytes
Become phagocytic macrophages. These ingest pathogens and process them in such a way that their unique antigenic properties are preserved and displayed on the surface of the macrophage. Doing so alerts the immune system to future presence of that specific pathogen.
Lymphocytes:
2 types, B cells (B lymphocytes) and T cells (T lymphocytes).
B cells
Originate and mature in bone marrow and protect against extracellular antigens. Respond to stimulation by a compatible T cell and begin producing plasma cells. Memory B cells retreat to the lymphatic system and remain prepared to repeat the same procedure upon a subsequent encounter with the same antigen.
Plasma cells
Create highly specific antibodies that bind to their corresponding antigens forming antigen-antibody complexes, which are highly unique molecules that lead to the destruction of the antigen.
T cells
Originate in bone marrow and mature in the lymphatic system. These protect against intracellular pathogens and cancer cells. There are cytotoxic T (CD8) cells, helper T (CD4) cells, suppressor T cells and memory T cells.
Cytotoxic T (CD8) cells
Determine and attack the specific weakness of the cell and destroys it.
Helper T (CD4) cells
Provide essential assistance to maintain B cell activity. These produce cytokines that activate, direct, and regulate most of the other components of the immune system. Require a threshold number to prevent shutdown of the immune system.
Suppressor T cells
Monitor and terminate humoral and cellular response when infection resolves.
Memory T cells
Migrate to lymphatic system and prepare for a second encounter should the same antigen reappear.
Cytokines
Hormonelike chemicals that act as messengers between B and T cells. These regulate the intensity and duration of the immune response and provide cell-to-cell communication.
Active immunity
Long-lasting immunity that’s rapid and much more effective during the second exposure than the first exposure.
aden/o
gland
agglutin/o
clumping, gluing
blast/o
embryonic cell
chrom/o
color
erythr/o
red
granul/o
granule
hem/o
hemat/o
blood
immun/o
immune, immunity, safe
leuk/o
white
lymph/o
lymph
lymphaden/o
lymph gland (node)
lymphangi/o
lymph vessel
morph/o
form, shape, structure
myel/o
bone marrow, spinal cord