Chapter 9 Allergies and immunologic diseases Flashcards
What is this?
Minor aphthous ulcer
Ulcerations are less than 1 cm
Heal without scaring in 1-2 weeks
1 to 5 lesions per episode
What makes up Melkersson-Rosenthal syndrome?
Cheilitis granulomatosa
Facial paralysis
Fissured tongue
What makes up Lofgren’s syndrome?
Erythema nodosum (red itchy skin lesions)
Bilateral hilar lymphadenopathy
Arthralgia
Sarcoidosis
Multisystem granulomatous disorder
African Americans >>> Caucasians
Organs most commonly involved:
Lungs
Lymph nodes
Skin
Eyes
Salivary glands
25% of pt have skin lesions called lupus pernio (H&N) or eythema nodosum (legs)
What is this?
Transient lingual papillitis
involve variable fungiform
Likely represents a hypersensitivity or allergy
Three patterns: Localized, Generalized, Diffuse, papulokeratotic variant
Reccurent aphthous ulcers
aphthous stomatitis
Exclusively occur on movable mucosa
3 types: Minor, major, and herpetiform
What is this?
Herpetiform aphthous ulcer
Greatest number of lesions and recurrences of the three clinical variants
Lesions are 1-3 mm in diameter (smallest)
Up to 100 ulcerations per occurrence
Ulcerations heal within 7-10d
How to diagnose Wegener’s granulomatosis
anca (antineutrophil cytoplasm antibodies)
P-anca (peripheral)
C-anca (cytoplasmic)-most useful
untreated=10% 2 year survival
Wegener’s granulomatosis
Necrotizing granulomatous lesions of respiratory tract, necrotizing glomerulonephritis, and systemic vasculitis of small arteries and veins
Strawberry gingivitis
What is this?
Major aphthous ulcer
Sutton’s disease
Take 2-6 w to heal
May cause scarring
Number of lesions per episode is 1-10
What makes up Heerfordt’s syndrome?
Parotid enlargement
Inflammation of eye
Facial paralysis
Fever
Histologic features of sarcoidosis
Diagnosis of sarcoidosis
Granulomatous inflamation, Asteroid bodies
Elevated serum angiotensin converting enzyme
What is used to treat aphthous ulcers
Topical steroid clobetasol propionate
What 2 syndromes accompany sarcoidosis?
Lofgren’s and Heerfordt’s
Behcet’s syndrome
Chronic, recurrent immune mediated disease with oral aphthous-like ulcerations, ocular inflammation, genital ulcers and skin lesions:
Joint pain is common complaint
Arthralgia, enlarged joints
What is this?
Orofacial granulomatosis
When lips are involved it is called cheilits granulomatosis
What is this?
Angioedema
Quincke’s disease
Diffuse edematous swelling of the soft tissues
Most common cause is mast cell degranulation, which leads to histamine release
IgE-mediated hypersensitivity reactions
Treatment for allergic angioedema is oral antihistamine therapy
Diffuse involvement of the head and neck can be caused by angiotensin-converting enzyme (ACE) inhibitors - (prils) - Iisinopril
