Chapter 8 - Types of Calcification

Question 1

Dysthrophic calcification tends to be…

Answer 1

Localized

Question 2

Metastatic calcification tends to be…

Answer 2

Widespread

Question 3

Dysthrophic calcification: non-infectious associated conditions

Answer 3

Liquefactive necrosis of chronic abscesses

Fat necrosis

Infarcts, thrombi

Psammoma bodies

CREST syndrome

Atherosclerotic plaques

Question 4

Metastatic calcification occurs in…

Answer 4

Kidney, lung, and gastric mucosa (Quickly lost of acid→ ↑pH → Ca2+deposition)

Nephrogenic diabetes insipidus and renal failure due to Nephrocalcinosis of collecting ducts

Question 5

Causes of Dysthrophic calcification

Answer 5

Injury and Necrosis

Question 6

Causes of Metastatic calcification

Answer 6

Hypercalcemia: 1° hyperparathyroidism, sarcoidosis, hypervitaminosis D

High calcium-phosphate product levels: chronic kidney disease with 2° hyperparathyroidism, long-term dialysis, calciphylaxis, multiple myeloma

Question 7

Calcium levels: Dysthrophic vs. Metastatic calcification

Answer 7

Dysthrophic: normal

Metastatic: high

Question 8

List infectious causes of dystrophic calcification✅

Answer 8

Granulomatous infections (TB, Syphilis)

Chronic abscesses

Schistosomiasis

Congenital CMV,

Toxoplasmosis

Rubella