Chapter 14 - Leukocyte extravasation

Question 1

Leukocyte Extravasation predominantly occurs at

Answer 1

postcapillary venules

Question 2

First Step of Leukocyte Extravasation

Answer 2

Margination and rolling → defective in LAD type 2

Question 3

In LAD type 2 we have ↓ of…

Answer 3

Sialyl Lewis x

Question 4

Which molecules play a role in Margination and rolling (Step 1 of Leukocyte Extravasation)?

Answer 4

E-selectin

P-selectin

GlyCAM-1, CD34

Question 5

P-selectin is released primarily from which endothelium-derived structure?

Answer 5

Weibel-Palade bodies

Question 6

Second Step of Leukocyte Extravasation

Answer 6

Adhesion (Tight binding)

Question 7

Molecules involved in Adhesion of Leukocytes

Answer 7

ICAM-1 (CD54)

VCAM-1 (CD106)

Question 8

Third Step of Leukocyte Extravasation

Answer 8

Diapedesis

Question 9

Molecule involved in Diapedesis

Answer 9

PECAM-1 (CD31)

Question 10

LAD 1 and LAD 2 are related to which steps of Leukocyte Extravasation?

Answer 10

LAD Type 1 → 2nd Step

LAD Type 2 → 1st Step

Question 11

Fourth Step of Leukocyte Extravasation

Answer 11

Migration

Question 12

Molecules that are involved in Migration (4th step)

Answer 12

P C I L K

C5a, IL-8, LTB4, kallikrein, platelet-activating factor