Chapter 12 - Acute Phase Reactants Flashcards
1
Q
Acute-phase Reactants
A
More Fish on the C
Ferritin Fibrinogen Serum amyloid A Hepcidin C-reactive protein
2
Q
What’s downregulated in inflammation?
A
Albumin and Transferrin
3
Q
What occurs to Transferrin during inflammation?
A
Internalized by macrophages to sequester iron
4
Q
What occurs to Ferritin during inflammation?
A
Sequesters iron to inhibit microbial iron scavenging
5
Q
Function of Hepcidin
A
↓ iron absorption (by degrading ferroportin) and ↓ iron release (from macrophages) → anemia of chronic disease
