Chapter 7.1 Flashcards
List the classic symptoms of Parkinson’s disease.
rigidity, resting tremor, Bradykinesia
State the precursor to dopamine that must be used in treatment of Parkinson’s disease.
Levodopa (L-DOPA)
State the role of carbidopa in therapy of Parkinson’s disease.
Most of the L-DOPA will be converted to dopamine before it reaches the brain
Carbidopa will help inhibit dopa decarboxylase to prevent premature conversion
List the common side effects of L-DOPA.
GI problems, hypotension, behavioral effects
List the types of behavioral changes that may be seen in patients using L-DOPA for Parkinson’s disease.
hallucinations, impulsive behaviors like excessive gambling like never before or hyper sexuality
end-of-dose akinesia
refers to when the drug’s effectiveness simply seems to wear off prior to the next dose
on-off phenomenon
the effectiveness of levodopa may suddenly and spontaneously decrease, resulting in the abrupt worsening of parkinsonian symptoms
State the length of time that L-DOPA therapy may be effective.
4-5 years
bromocriptine is a blank type of drug
dopamine agonist
entacapone is a blank type of drug
COMT inhibitors
benztropine is a blank type of drug
anticholinergic agent
selegiline is a blank type of drug
MAO inhibitor
amantadine is a blank type of drug
Anitviral drug
Dopamine agonists mechanism of action (MOA)
Has to cross BBB and stimulate dopamine receptors in basal ganglia. We think that the D2 receptors are the most important
COMT inhibitors (MOA)
Help L-Dopa reach the brain as L-Dopa
