Chapter 67 & 68 steroids + thyroid Flashcards
in addisons disease do you need to add or take away steroids
you need to ADD steroids since there is a deficiency (ADDison’s disease)
in cushing’s syndrome do you need to add or reduce the amount of steroids
you need to reduce the amount of steroids since the person has to much
what are two things corticosteroids are frequently used for**
-Suppress the inflammatory process
-decrease the immune responses
What are 3 important patient teachings for pts on long term steroid therapy***
-avoid live vaccines
-report weight gain of over 2 lb in one day
-oral route is the best option for long term use
what are 6 adverse effects of corticosteroids **
-Suppression of the immune system
-Decreased inflammatory response
-GI bleeds/peptic ulcers
-osteoporosis
-behavioural changes
-metabolic changes/fat redistribution (buffalo hump)
what are the two kinds of corticosteroids
Glucocorticoides
Mineralocorticoids
why do you gradually taper off of corticosteroids**
to give time for the adrenal glands to kick back into producing steroids again if you don’t it can result in an adrenal crisis and death
what is the prototype glucocorticoide
hydrocortisone (so if someone needs more glucocorticoides they give them this)
what are 4 drug interactions with glucocorticoids ***
-Potassium-wasting drugs
-anticholinesterase drugs
-toxoids
-insulin and oral hypoglycemic drugs
what drugs do corticosteroids in increase the effectiveness of**
Erythromycin
Ketoconazole
what drugs do corticosteroids decrease the effectiveness of**
Salicylates
barbiturates
phenytoin
rifampin
What is addison’s disease
when the adrenal cortex does not secrete enough aldosterone (mineral corticosteroid)
what is the prototype mineralocorticosteroid**
fludrocortisone
what is the mechanism of action for fludrocortisone***
acts on kidneys to promote water and Na reabsorption and increases K excretion
what do T3 and T4 hormones stimulate
they stimulate basal metabolic rate (rev the engine)
