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HEMA 1 LEC > Chapter 6 - WBC and PLATELET STUDIES > Flashcards

Chapter 6 - WBC and PLATELET STUDIES Flashcards

1
Q

• Large purple to black azurophilic granules

A

Toxic granulation

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2
Q

altered primary granules

A

Toxic granulation

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3
Q

Severe infection

A

Toxic granulation

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4
Q

chemical poisoning

A

Toxic granulation

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5
Q

toxic states

A

Toxic granulation

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6
Q

• larger than 2° granules and stain dark blue - black.

A

Toxic granulation

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7
Q

blue, round or elongated bodies

A

Doble bodies /Amato

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8
Q

Single or multiple, arranged in parallel rows

A

Doble bodies /Amato

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9
Q

Aggregates of free ribosomes

A

Doble bodies /Amato

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10
Q

Severe infections, burn, surgery

A

Doble bodies /Amato

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11
Q

chemotherapy

A

Doble bodies /Amato

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12
Q

May - Hegglin

A

Doble bodies /Amato

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13
Q

Large empty areas within the cell

A

Cytoplasmic vacuolation

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14
Q

Represents end stage of phagocytosis

A

Cytoplasmic vacuolation

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15
Q

Septicemia, severe infections, toxic states

A

Cytoplasmic vacuolation

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16
Q

Cells show foamy cytoplasm

A

Atypical/Reactive lymphocyte/ Downey cells

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17
Q

seen in Infectious Mononucleosis

A

Atypical/Reactive lymphocyte/ Downey cells

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18
Q

Neutrophils have single or bilobed nuclei

A

Hypolobulation

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19
Q

Decreased segmentation

A

Hypolobulation

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20
Q

Pelger-Huet Anomaly

A

Hypolobulation

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21
Q

Neutrophils show more than 4 lobes

A

Hypersegmentation

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22
Q

Abnormal DNA synthesis

A

Hypersegmentation

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23
Q

Megaloblastic anemia

A

Hypersegmentation

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24
Q

shrunken and dehydrated nucleus of cells that are about to die

A

Pyknotic cell

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25
Q

nuclear remnant of lymphocyte, seen after smear preparation

A

Smudge cell

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26
Q

Thumbprint appearance; associated with CLL

A

Smudge cell

27
Q

nuclear remnants of granulocytic cell

A

Basket cell

28
Q

drumstick like body attached on one of the lobes of neutrophil nucleus

29
Q

Pink or red rod-shaped structures

30
Q

Fused primary granules; Seen in AML

31
Q

Large, coarse blue-black granules in all WBCs

A

Alder - Reilly Granulation

32
Q

abnormal polys accharide metabolism which prevents the formation of secondary granules

A

Alder - Reilly Granulation

33
Q

characterized by leucopenia, variable thrombocytopenia, giant platelets

A

May - Hegglin anomaly

34
Q

Presence of gray - blue spindle shaped inclusions in the cytoplasm of Neutrophils and Monocytes

A

May - Hegglin anomaly

35
Q

Random movement of phagocytes is normal but directional motility is impaired

A

Job’s Syndrome

36
Q

Cells respond slowly to chemotactic agents

A

Job’s Syndrome

37
Q

Characterized by large, blue to grayish granules in Neutrophils that vary in size and color and stain positive with peroxidase, Sudan black B (SBB) and Acid phosphatase (ACP) stains.

A

Chediak Higashi Anomaly

38
Q

granules are normal in content but abnormally packaged

A

Chediak Higashi Anomaly

39
Q

Phagocytes ingest but cannot kill catalase (+) organism because of lack of appropriate respiratory burst

A

Chronic Granulomatous Disease

40
Q

screening test for neutrophil function (ability of neutrophils to attack bacteria)

A

NTR (Nitroblue Tetrazolium Reduction ) test

41
Q

yellow water soluble dye is reduced to insoluble blue formazan

A

NTR (Nitroblue Tetrazolium Reduction ) test

42
Q

tests migration of N in response to a chemotactic factor

A

Boyden micropore filter

43
Q

evaluates the speed, type and number of phagocytes that respond to a skin abrasion

A

Rebuck skin window

44
Q

emission of low-level light pulses by stimulated cell

A

Chemiluminescence:

45
Q

a stimulated or atypical lymphocyte with denser and more opaque cytoplasm

A

Ferrata cell

46
Q

associated with SBE

A

Ferrata cell

47
Q

a lymphocyte with notched, lobulated, segmented, clover leaf like nucleus

A

Reider Cell

48
Q

associated with chronic lymphocytic leukemia

A

Reider Cell

49
Q

Neutrophil with large purple homogenous round inclusion with nucleus wrapped around

50
Q

A lymphocyte with hair-like cytoplasmic projections

A

Hairy cell

51
Q

Round lymph cell with nucleus that is grooved or convoluted

A

Sezary cell

52
Q

Seen in Sezray syndrome

A

Sezary cell

53
Q

plasma cell with red to pink cytoplasm; Associated with increase in IgA

A

Flame cell

54
Q

plasma cell that contains small colorless (or blue or pink) vacuoles

A

Grape cell/Mott cell, Morula cell

55
Q

large protein globules giving the appearance of grapes

A

Grape cell/Mott cell, Morula cell

56
Q

Mucopolysaccharidoses

A

I Hurlers
II Hunters
III Sanfilippo
IV Morquio Ullrich
V Scheie
VI Maroteaux Lamy

57
Q

lack of b- glucosidase resulting to the accumulation of glucocerebrosides in the spleen, liver and bone marrow

A

Gaucher’s disease

58
Q

Gaucher cell cytoplasm is distended with glucocerebroside; spongelike appearance

A

Gaucher’s disease

59
Q

deficiency of sphingomyelinase resulting to accumulation of sphingomyelin and cholesterol in the macrophages

A

Niemann Pick disease

60
Q

accumulation in the spleen and BM of histrocytes filled with lipid- rich granules that stain blue green with polychrome stains

A

Sea blue histrocytes

61
Q

s/s: hepatomegaly, thrombocytopenia

A

Sea blue histrocytes

62
Q

lack of a-galactosidase resulting to accumulated glycolipid trihexosyl ceramide

63
Q

deficiency of acid esterase resulting to accumulation of TG and cholesterol

A

Wolman Disease

64
Q

Patient is unable to produce HDL, as a result, cholesterol esters accumulate

A

Tangier’s disease

HEMA 1 LEC (15 decks)

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