Chapter 6 Allostery Flashcards
1
Q
allosteric enzymes have a ____ curve
A
sigmoidal
don’t follow M-M kinetics
2
Q
do allosteric enzymes tend to have more than 1 subunit?
A
yes
3
Q
do allosteric enzymes tend to have more than 1 conformation?
A
yes, mediated by small molecule binding (modulator binding)
4
Q
activators stabilize…
A
high affinity state
5
Q
inhibitors stabilize…
A
low affinity state
6
Q
when are allosteric enzymes found in the pathway?
A
at the 1st committed step
evolution
7
Q
post-translational modification
A
covalent modification that controls activity
conformational change occurs upon adding/removing a covalently bound small molecule
