Chapter 3 Flashcards
proteins are made from _ amino acids only
L
amide bond
peptide bond
partial double bond char… planar, can’t rotate
to make peptide bond
COO- attacks NH3+ and H2O is removed (condensation rxn)
primary structure
sequence of aa codes
why do proteins fold?
entropy increase by hiding NP groups on inside of structure
sequence of AAs dictates…
structure
what denatures proteins?
temp, [salt], pH, organic solvents
disrupt H-bonding, ionic interactions, hydrophobic interactions
folding is usually reversible?
yes
do proteins slowly unfold?
no
what drives protein folding?
increased entropy of the solvent
unfolded proteins have ____s of conformations
thousands
what are phi and psy limited by?
other AAs
R groups
Ramachandran plot predicts phi and psy using…
van der waals radii
interpret Ramachandran…
more branching away from alpha-C is more free to rotate
branching or bulkiness near alpha-C is less rotatable
