Chapter 6 Flashcards
Bone is hard and rigid; cartilage is flexible yet strong. Cartilage in nose, external ear, thoracic cage and trachea.
Support
connect bone to bone.
Ligaments
Skull around brain; ribs, sternum, vertebrae protect organs of thoracic cavity.
Protection
Produced by muscles attached to bones via tendons.
Movement
Calcium and phosphate stored and released as needed. Adipose tissue stored in marrow cavities
Storage
Bone marrow that gives rise to blood cells and platelets
Blood cell production
form matrix.
Chondroblasts
surrounded by matrix; are within lacunae.
Chondrocytes
Collagen fibers for strength, proteoglycans for resiliency.
Matrix
Double-layered C.T. sheath. Covers cartilage except at articulations.
Perichondrium
More delicate, has fewer fibers, contains chondroblasts.
Inner Perichondrium
Blood vessels and nerves penetrate. No blood vessels in cartilage itself
Outer Perichondrium
Covers bones at joints; has no perichondrium Growth.
Articular cartilage
New chondrocytes and new matrix at the periphery.
Appositional
Chondrocytes within the tissue divide and add more matrix between the cells.
Interstitial
If mineral removed,
bone is too bendable
If collagen removed,
bone is too brittle.
Bone-building cells, produce collagen and proteoglycans
OSTEOBLASTS
produced by E.R. and golgi apparatus. Released by exocytosis.
Collagen
stored in vesicles, then released by exocytosis
Precursors of hydroxyapatite
Formation of bone by osteoblasts.
communicate through gap junctions.
Cells surround themselves by matrix.
OSSIFICATION
Mature bone cells.
Stellate.
Surrounded by matrix but can make small amounts of matrix to maintain it
OSTEOCYTES
spaces occupied by osteocyte cell body.
Lacunae
canals occupied by osteocyte cell extensions.
• Nutrients and gases can pass through:
• the small amount of fluid surrounding the cells in the canaliculi and lacunae
Canaliculi
Resorption of bone.
OSTEOCLASTS
the specialized reabsorption-specific area of the membrane
Ruffled border
are secreted into the extracellular space, enter the blood, and are used elsewhere in the body.
Degradation products
Stem cells called ____ can become osteoblasts or chondroblasts?
osteochondral progenitor cells
from osteochondral progenitor cells
Osteoblasts
from osteoblasts
Osteocytes
from stem cells in the red bone marrow
Osteoclasts
Brittle bone disorder
OSTEOGENESIS IMPERFECTA
caused by mutations that yield reduced or defective Type I collagen
CT disease
• Mildest, most common form
• Too little formation of normal type I collagen
• Bones are predisposed to fracture, tendency to develop spinal curvature
Type I Ol
Unlike those with more severe forms of Ol, these patients have normal or near-normal stature and minimal or no bone deformities
Type I Ol
• Most severe
• Usually lethal within the 1st week of life due to breathing failure caused by rib fractures and underdeveloped lungs
Type II Ol
Characterized by bones that fracture very easily, even before and during birth.
Fractures occurring before birth often heal in poor alignment, leaving the limbs short and bent.
Type Ill Ol
Collagen fibers randomly oriented.
• First type of bone formed by osteoblasts during ossification.
Woven bone
• Osteoclasts remove old bone and osteoblasts add new.
• Woven bone is remodeled into lamellar bone.
Remodeling
Mature bone in concentric sheets or layers called?
lamellae
appears porous
Spongy bone
interconnecting rods or plates of bone. Like scaffolding.
Trabeculae
Solid, outer layer surrounding each bone; has more matrix and is denser than spongy bone.
Blood vessels enter the bone and the lamellae are oriented around the blood vessels.
Compact Bone
Functional unit of compact bone is an?
osteon or haversian system.
Composed of concentric rings of matrix around a ____ , giving the appearance of a bulls-eye?
central canal
parallel to long axis.
Central or Haversian canals
concentric, circumferential, interstitial
Lamellae
perpendicular to long axis.
Perforating or Volkmann’s canal
Center portion of the bone
Diaphysis
primarily composed of compact bone surrounding the medullary cavity.
Shaft