Chapter 6 Flashcards
Arcuate Nucleus (ARC)
master hypothalamic centre for food intake control
- main part of hypothalamus
NYP/ AgRP
increase eating and reduce metabolism by releasing these peptides
POMC Neurons
decrease eating; release POMC and activate neurons that make you feel full therefore decreasing eating
- also glutamate
GABA
increases eating
Lateral Hypothalamus
brain region that initiates eating and controls aspects of feeding behaviour and metabolic responses
- gastric juice secretion
- insuline production
- process reward value of different food and how palatable different foods are
Orexin
increase eating and wakefullness in response to food deprivation
- excites the NPY neurons and inhibits the POMC neurons
Paraventricular Nucleus
regulate eating and metabolic process
- body temp, fat storage and cellular metabolism
- POMC stimulate this and that causes a reduction in eating
- NYP and AgRP inhibit this
Ventromedial Hypothalamus
brain region that reduces satiety and increase metabolism
- only receives info from POMC
Ghrelin
orexigenic peptide hormone synthesized in the stomach and released into bloodstream during fasting
- increases eating
- stimulates growth hormone release
- anticipatory hormone; released before each meal and drops immediately after you begin eating
Cholecystokinin
peptide hormone that is best known satiety signal, released by stomach and small intestine as food passes into duodenum
- limits mean size and aids digestion
- does not reduce total food intake
PYY
released in the intestine in response to food, suppressing appetite over longer period of time
- increased PYY, decrease total food intake
Leptin
peptide hormone secreted by fat cells that inhibits eating
- reduce meal size and total daily intake
BMI
quantifier of leanest or obesity calculated by dividing persons weight in kilograms by squared height in meters
- increased health risks; diabetes, high blood pressure, heart disease, stroke, cancer , alheizmers, shorter life spans
- cannot be characterized by lack of impulse control, inability to delay gratification, or maladaptive eating style
- factors that lead to obesity are common to the ones that lead to drug addiction
Obesity Gene
gene on chromosome 6 linked to obesity in mice, signified as ‘ob’
- recessive gene
Diabetes
gene on chromosome 4 linked to obesity in mice, signified as db
- recessive gene
Epigenetic
modifications to DNA that turn genes ‘on; or ‘off’ without changing dene’s DNA sequence