Chapter 5 Study Questions (Part 2)

Question 1

ADH is made from a ________ encoded by the _____ gene

Answer 1

ADH is made from a prepropeptide encoded by the AVP gene

Question 2

what is the job of the signal sequence

Answer 2

mark the protein for secretion

Question 3

what marks the prepropeptide for secretion?

Answer 3

signal sequence

Question 4

why is the AVP region cleaved?

Answer 4

to make ADH/vasopression

Question 5

ADH/vasopressin is made by

Answer 5

cleaving the AVP region

Question 6

what becomes the carrier to transport ADH from where it’s made to where it will be released?

Answer 6

neurophysin II region

Question 7

role of neurophysin region

Answer 7

becomes the carrier to transport ADH from where it’s made to where it will be released

Question 8

what’s the mnemonic for starting and stopping secondary messenger signaling

Answer 8

Lee’s
Got
A
Penguin
Steven…
He’s
Dead

Question 9

Lee’s

Answer 9

start: ligand binds receptors and attracts G protein

Question 10

Got

Answer 10

G protein alpha subunit drops GDP, picks up GTP, becomes activated, dissociates and goes off and activates its target (ex. adenylate cyclase0

Question 11

A

Answer 11

Adenylate cyclase makes cAMP that binds to and removes repressor protein from PKA

Question 12

what is PKA?

Answer 12

protein kinase A

Question 13

what is cyclase?

Answer 13

takes ATP and cyclizes to AMP and cyclizes it to ATP and…

Question 14

Penguin

Answer 14

PKA phosphorylates its target to change that target’s function

Question 15

Steven

Answer 15

Stop: remove ligand from receptor

Question 16

He’s

Answer 16

hydrolyze GTP to GDP on alpha subunit. now the alpha subunit rejoins the beta and gamma subunits and now is able to rejoin the receptor if ligand rebinds

Question 17

Dead

Answer 17

degrade cAMP to AMP by cAMP phosphodiesterase to inactivate PKA