Chapter 48 Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

What is the major physiological challenge facing all multicellular animals?

A

obtaining sufficient O2 and getting rid of excess CO2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Which animal is the respiratory champion?

A

elephant seals, which can hold their breath for over 2 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Invertebrates display a wide variety of respiratory organs, including

A

the epithelium; tracheae; gills

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which vertebrates use gills?

A

fish; larval amphibians

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What do adult amphibians use to respire?

A

skin; other epithelia (either supplementary or primary external respiratory organ)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Generally speaking, which animals have lungs?

A

adult amphibians; reptiles; birds; mammals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

(T/F) Lungs are only present in terrestrial animals.

A

False, lungs are also present in aquatic animals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is necessary for plasma membranes to be stable?

A

Plasma membranes must be surrounded by water to be stable

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

The external environment in gas exchange is always

A

aqueous (even in terrestrial animals, since a fluid lines the respiratory organs)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What drives the diffusion of gas into the fluid layer surrounding respiratory organs in vertebrates?

A

passive diffusion - concentration difference between O2 and CO2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

For dissolved gases, concentration is usually expressed in

A

partial pressure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What law governs the relationship of the rate of diffusion between two regions?

A

Fick’s Law of Diffusion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What does Fick’s Law of Diffusion say?

A

the rate of diffusion (R) is directly proportional to the pressure difference (Δp) between the two sides of the membrane and the area (A) over which the diffusion occurs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the relationship between R and d in Fick’s Law?

A

R is inversely proportional to the distance (d)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Write out Fick’s Law.

A

write out pg. 1002

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

How can R in Fick’s Law be optimized?

A

increase area; decrease distance; increase concentration difference

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is the maximum diffusion distance for the levels of oxygen needed by cellular respiration?

A

0.5 mm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What are the consequences for the maximum diffusion distance of O2 at 0.5 mm?

A

bacteria are small enough, but multicellular animals require structural adaptations to enhance gas exchange

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Do invertebrates have specialized respiratory organs?

A

No, they lack specialized respiratory organs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

How do invertebrates increase the oxygen concentration difference?

A

some create a water current that continuously replaces the water over respiratory surfaces

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Which invertebrates possess respiratory organs?

A

mollusks; arthropods; echinoderms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Give two ways in which respiratory organs maximize Fick’s law.

A

bring the external environment closer to the internal fluid to minimize distance; maximizes surface area

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Which factor is affected by continuously beating cilia?

A

concentration difference (because beating cilia continuously replenishes water/O2)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What are gills?

A

specialized extensions of tissue that project into water

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

What is the simplest form of gills?

A

papillae of echinoderms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

What is the most complex form of gills?

A

highly convoluted gills of fish

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

What is the primary advantage of gills in terms of respiration?

A

enables aquatic organisms to extract far more oxygen from water than would be possible from just body surface

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

External gills are found in what organisms?

A

fish; amphibian larvae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Give examples of organisms with external gills.

A

larvae of many fish/amphibians; axolotl (amphibian)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

What is unusual about the axolotl?

A

retains larval features throughout its life

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

What are the disadvantages of external gills?

A

must be constantly moved to ensure contact w/ fresh water w/ high O2; significant resistance to movement; easily damaged

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

What are branchial chambers?

A

structures that provide a means of pumping water past stationary gills

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

What is the composition of air?

A

21% oxygen; 78% nitrogen; <1% CO2 + other gases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Describe the nature of nitrogen gas in air.

A

inert; not part of respiratory processes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

What is atmospheric pressure?

A

pressure exerted by the atmosphere on the body surfaces of animals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

What is 1 kPa in mm Hg?

A

1 kPa = 7.5 mm Hg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

What is sea level in terms of mm Hg?

A

760 mm Hg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

(T/F) Atmospheric percentiles change as altitude changes.

A

False, atmospheric percentiles do NOT change with changing altitudes.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

Compare the rate of oxygen diffusion into blood at higher and lower elevations.

A

At higher elevations, rate is lower; at lower elevations, rate is higher

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

Are most gases able to dissolve in water?

A

No, most gases dissolve poorly in water

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

What are three factors that increase the solubility of gases in water?

A

higher pressure; cold water; lack of other solutes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

(T/F) The respiratory system is independent of the vascular system.

A

True, the respiratory system is independent of the vascular system.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

What is the minimum number of cell layers for entering the bloodstream?

A

2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
44
Q

What is the branchial chamber in mollusks?

A

mantle cavity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
45
Q

Describe the structure of the mantle cavity.

A

opens to the outside; contains the gills

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
46
Q

How does the mantle cavity function as a branchial chamber?

A

contraction of the muscular wall of the mantle cavity draws in water through inhalant siphon and expels through exhalant siphon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
47
Q

Where is the branchial chamber located in crustaceans?

A

between the bulk of the body and the hard exoskeleton of the animal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
48
Q

Describe the structure of the branchial chamber in crustaceans.

A

opens to the surface beneath a limb; contains gills

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
49
Q

How does the branchial chamber in crustaceans function?

A

movement of limb draws water through branchial chambers which creates current over gills

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
50
Q

Branchial chambers are found in which types of organisms?

A

mollusks; crustaceans

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
51
Q

Where are the gills of bony fishes located?

A

between oral cavity and opercular cavity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
52
Q

What is another name for the oral cavity found in bony fishes?

A

buccal (mouth) cavity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
53
Q

What purpose do the buccal and opercular cavities serve in respiration in bony fishes?

A

they are pumps that expand alternately to move water into mouth, through gills, and out of body via open opercula

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
54
Q

Which fish have immobile opercula and why?

A

tuna, because they swim continuously

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
55
Q

How do fish with immobile opercula breathe?

A

swim with mouths partly open, which constantly forces water over gills

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
56
Q

What is ram ventilation?

A

bony fishes with immobile opercula swim with mouths partly open, which constantly forces water over gills

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
57
Q

What is the remora?

A

bony fish that rides piggyback on sharks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
58
Q

How does the remora breathe?

A

when hitched to a shark, uses ram ventilation; uses normal pumping action when shark stops swimming

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
59
Q

How many gill arches can be found on each side of the fish’s head?

A

between 3 and 7 gill arches

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
60
Q

Each gill arch is composed of

A

two rows of gill filaments

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
61
Q

Each gill filament is composed of

A

lamellae, which project out into the flow of water

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
62
Q

How do blood and water flow with respect to lamellae?

A

Blood flows in the opposite direction of water flow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
63
Q

What is countercurrent exchange?

A

blood and water flow in opposite directions in lamellae to maximize oxygenation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
64
Q

How does countercurrent exchange maximize oxygenation in terms of Fick’s law?

A

it maintains a positive oxygen gradient along the entire pathway for diffusion, which increases Δp in Fick’s law

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
65
Q

If blood and water flowed in the same direction, it would be called

A

concurrent flow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
66
Q

Why isn’t concurrent flow a good idea?

A

because the concentration difference would decrease and there would eventually be no further net diffusion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
67
Q

What is the most efficient respiratory organ?

A

gills, because of countercurrent exchange

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
68
Q

What is cutaneous respiration?

A

process of exchanging oxygen and CO2 across skin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
69
Q

Describe cutaneous respiration in amphibians.

A

supplements (sometimes replaces) action of the lungs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
70
Q

Can animals respire exclusively through cutaneous respiration?

A

Yes, some terrestrial amphibians such as plethodontid salamanders use cutaneous respiration exclusively

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
71
Q

Which animals use cutaneous respiration?

A

amphibians; reptiles (like turtles)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
72
Q

Why do terrestrial reptiles have dry/tough skin?

A

to prevent desiccation and to prevent cutaneous respiration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
73
Q

What are tracheae?

A

small, branched cuticle-lined air ducts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
74
Q

Where are tracheae found?

A

terrestrial arthropods

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
75
Q

Tracheae branch into

A

tracheoles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
76
Q

What are tracheoles?

A

series of tubes that transmit gases throughout the body

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
77
Q

In arthropods, how is oxygen delivered to cells?

A

tracheoles are in direct contact with individual cells so that oxygen can diffuse directly across plasma membranes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
78
Q

How does air enter the tracheae of arthropods?

A

passes through specialized openings of the exoskeleton called spiracles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
79
Q

What are spiracles?

A

specialized openings of the exoskeleton through which air passes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
80
Q

How are spiracles opened and closed?

A

valves

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
81
Q

What was the major evolutionary mechanism that allowed arthropods to invade land?

A

prevention of water loss by closing spiracles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
82
Q

Why were gills replaced with lungs in terrestrial animals?

A

air is less supportive than water; water evaporates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
83
Q

Elaborate on “air is less supportive than water.”

A

gills lack structural strength and rely on water for support; if a fish were to live out of water, they would have plenty of O2 but would suffocate since the gills would collapse

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
84
Q

(T/F) Air is usually saturated with water.

A

False, air is rarely saturated with water vapor (except after a rainstorm).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
85
Q

Elaborate on “water evaporates.”

A

Gills would provide an enormous surface area for water loss.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
86
Q

How does the lung minimize water evaporation?

A

moves air through a branched tubular passage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
87
Q

Describe the directionality of air flow in lungs.

A

two-way flow in the same airway passage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
88
Q

What natural phenomenon allows for the constancy of atmospheric composition of gases?

A

convection currents

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
89
Q

What is a barometer?

A

apparatus that measures air pressure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
90
Q

What is the maximum altitude for human survival?

A

6000 m

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
91
Q

Describe the appearance of lungs in amphibians.

A

saclike outpourings of the gut

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
92
Q

Compare the surface area available in the lungs of amphibians to the surface area available in the lungs of other terrestrial vertebrates.

A

less surface area in amphibian lungs than in other terrestrial vertebrate lungs

93
Q

The opening to each amphibian lung is controlled by

A

a valve called the glottis

94
Q

Which mechanism do amphibians use to breathe?

A

positive pressure breathing

95
Q

What is positive pressure breathing (in amphibians)?

A

they fill oral cavity with air and elevate floor of oval cavity, which pushes air into the lungs

96
Q

Give an analogy for positive pressure breathing in humans.

A

forcing air into a person’s lung by performing mouth-to-mouth resuscitation

97
Q

Which mechanism do most reptiles use to breathe?

A

negative pressure breathing

98
Q

What is negative pressure breathing?

A

they expand rib cages by muscular contraction which creates lower pressure inside lungs, which pushes air into lungs

99
Q

What are alveoli?

A

tiny grape-like sacs that provide more surface area for gas exchange

100
Q

How thick is the epithelium of an alveolus?

A

one cell thick

101
Q

How thick are the blood capillaries surrounding alveoli?

A

one cell thick

102
Q

What is the distance for gas diffusion in bird/mammalian alveoli?

A

0.5 to 1.5 micrometers (very small)

103
Q

Describe the passage of air in the mammalian respiratory system.

A

air is inhaled through mouth/nose past pharynx into larynx; then passes through glottis; then passes into tracheae; passes into left or right bronchus; passes into bronchioles; passes into alveoli

104
Q

The mammalian tracheae is divided into

A

right and left bronchi

105
Q

In human lungs, how many alveoli are there?

A

each lung contains about 300 million alveoli

106
Q

What is the total surface area available for diffusion in the human lung?

A

80 m^2 (42x surface area of body)

107
Q

Which animal has the most efficient respiratory system among terrestrial vertebrates?

A

avians

108
Q

Where does gas exchange occur in the avian respiratory system?

A

air is channeled through tiny vessels called parabronchi, where gas exchange occurs

109
Q

Describe the directionality of air flow in avians.

A

air flow in parabronchi is one-directional; old air exits lungs by different route

110
Q

In other terrestrial vertebrates, the two-directional flow of air results in

A

inhaled fresh air mixing with old, oxygen-depleted air

111
Q

What two unique structures in birds help with unidirectional air flow?

A

the anterior and posterior air sacs

112
Q

How is unidirectional air flow accomplished in birds?

A

both anterior and posterior sacs expand upon inflation but only posterior sac is filled w/ new air; anterior sac fills with old air pulled from lungs; upon exhalation old air in anterior sac is pushed out of body and new air in posterior sac enters lungs

113
Q

How many cycles of respiration are there in birds?

A

two cycles, but the air inhaled in the first cycle isn’t exhaled until the second cycle

114
Q

Draw out the two cycles of respiration in birds.

A

draw page 1009, Figure 48.9

115
Q

In what ways does the unidirectional air flow in birds permit further respiratory efficiency?

A

crosscurrent blood flow has greater capacity to extract oxygen from air

116
Q

What is crosscurrent blood flow in birds?

A

flow of blood through avian lung runs at 90 degree angle to air flow

117
Q

In terms of everyday life, why do birds need a much more efficient respiratory system?

A

because they often fly at really high altitudes, where less oxygen is available

118
Q

How many capillaries can be found in each lung?

A

about 30 billion (100 capillaries per alveolus)

119
Q

Blood returning from systemic circulation has a PO2 of

A

40 mmHg

120
Q

The PO2 in alveoli is

A

105 mm Hg

121
Q

Blood leaving the lungs has a PO2 of

A

100 mHg

122
Q

If the PO2 in alveoli is 105 mmHg and blood leaving the lungs has a PO2 of 100 mmHg, what does this mean?

A

the lungs do a very efficient - but not perfect - job of oxygenating blood

123
Q

What thin membrane covers the outside of each lung?

A

visceral pleural membrane

124
Q

What is the visceral pleural membrane?

A

thin membrane that covers the outside of each lung

125
Q

What membrane covers the inner wall of the thoracic cavity?

A

parietal pleural membrane

126
Q

What is the parietal pleural membrane?

A

lines the inner wall of the thoracic cavity

127
Q

What is the pleural cavity?

A

the space between the visceral pleural membrane and the parietal pleural membrane; small and filled with fluid

128
Q

What is the purpose of the fluid in the pleural cavity?

A

causes the parietal pleural membrane to stick to the visceral pleural membrane, which couples the lungs to the thoracic cavity

129
Q

Describe why the two lungs aren’t packaged together.

A

The pleural membranes package each lung separately so that if one lung collapses, the other lung can still function

130
Q

During mammalian inhalation, how is thoracic volume increased?

A

through contraction of two sets of muscles: external intercostal muscles and the diaphragm

131
Q

Contraction of the external intercostal muscles results in

A

raising of the ribs and expansion of the rib cage

132
Q

Contraction of the diaphragm results in

A

the diaphragm lowering and assuming a more flattened shape

133
Q

What is the diaphragm?

A

convex sheet of striated muscle separating the thoracic cavity from the abdominal cavity

134
Q

What kind of breathing mechanism do mammals/humans employ?

A

negative pressure ventilation

135
Q

Expansion of the thoracic volume places the thorax and lungs under what tension?

A

elastic tension

136
Q

Why do humans have unforced exhalation?

A

because the relaxation of the external intercostal muscles/diaphragm releases the elastic tension which allows the thorax and lungs to recoil

137
Q

What muscles are used to force inhalation in humans?

A

accessory respiratory muscles like the sternocleidomastoid

138
Q

Each breath in a human moves how much air into and out of the lungs?

A

tidal volume of 500 mL of air moves into and out of the lungs

139
Q

What is anatomical dead space?

A

tubular passages (trachea, bronchi, bronchioles) where no gas exchange occurs

140
Q

How much tidal volume is contained in the anatomical dead space?

A

150 mL of tidal volume is in the anatomical dead space

141
Q

What is the vital capacity?

A

maximum amount of air that can be expired after a forceful, maximum inhalation

142
Q

What is the vital capacity in young men?

A

4.6 L

143
Q

What is the vital capacity in young women?

A

3.1 L

144
Q

Why is the vital capacity clinically important?

A

abnormally low vital capacity can indicate damage to alveoli

145
Q

What is hypoventilation?

A

insufficient breathing to maintain normal blood gas measurements

146
Q

What is the best indicator of hypoventilation?

A

rise in blood PCO2

147
Q

What is hyperventilation?

A

excessive breathing

148
Q

What is the best indicator of hyperventilation?

A

abnormally low blood PCO2

149
Q

Why is increased breathing during exertion not considered hyperventilation?

A

because the faster/more forceful breathing is matched to the higher metabolic rate, so blood gas measurements are still normal

150
Q

Ventilation, generally speaking, is controlled by

A

the nervous system

151
Q

Each breath is initiated by

A

neurons in the respiratory control center

152
Q

Where is the respiratory control center located?

A

medulla oblongata

153
Q

What stimulates the external intercostal muscles/diaphragm to contract?

A

neurons in the respiratory control center

154
Q

What causes the external intercostal muscles/diaphragm to relax?

A

neurons in the respiratory control center stop producing impulses

155
Q

What kind of muscle is used for breathing muscles?

A

skeletal BUT they are usually controlled automatically; can be voluntarily overridden

156
Q

What is the primary initiator for the urge to breathe?

A

rise in PCO2 rather than a fall in PO2

157
Q

A rise in PCO2 results in

A

increased production of H2CO3

158
Q

What effect does H2CO3 have on blood pH?

A

H2CO3 lowers blood pH (more acidic)

159
Q

A fall in blood pH results in

A

stimulation of chemosensitive neurons in the aortic and carotid bodies

160
Q

Where are the aortic and carotid bodies located?

A

aorta and carotid artery, respectively

161
Q

When stimulated, what do the aortic/carotid bodies do?

A

send impulses to the respiratory control center, which stimulates increased breathing

162
Q

What other mechanism, other than aortic and carotid bodies, exists to stimulate breathing when blood pH is too low?

A

brain contains central chemoreceptors that are stimulated by a drop in the pH of cerebrospinal fluid (CSF)

163
Q

Why can’t a person voluntarily hyperventilate for too long?

A

because the decreases in PCO2 and increase in blood pH suppresses the reflex drive to breathe

164
Q

Why does deliberate hyperventilation allow people to hold their breath longer?

A

because CO2 levels are lowered, which takes longer to build back up and postpones the need to breathe

165
Q

For people with normal longs, when does PO2 become a primary initiator?

A

at high altitudes where PO2 is low

166
Q

What does COPD stand for?

A

chronic obstructive pulmonary disease (COPD)

167
Q

What are COPDs?

A

any disorder that obstructs air flow on a long-term basis

168
Q

List the major COPDs.

A

asthma; chronic bronchitis; emphysema

169
Q

What happens in asthma?

A

allergen triggers release of histamine or other inflammatory chemicals which can cause constriction of bronchi or suffocation

170
Q

What happens in emphysema?

A

alveolar walls break down and the lung exhibits larger but fewer alveoli; lungs become fibrotic and less elastic; air passages open adequately but collapse and obstruct outflow of air

171
Q

What is the primary cause of emphysema?

A

cigarette smoking

172
Q

Which cancer accounts for more deaths than any other cancer?

A

lung cancer

173
Q

Is lung cancer a COPD?

A

no, it usually follows or accompanies a COPD

174
Q

What is the most important cause of lung cancer?

A

cigarette smoking

175
Q

What is the second-most important cause of lung cancer?

A

air pollution

176
Q

Where do most lung tumors originate?

A

mucous membranes of large bronchi

177
Q

How do lung tumors affect breathing?

A

as the tumor invades the bronchial wall and grows around it, it compresses airway and may cause collapse of distal parts of the lung

178
Q

Why is lung cancer in smokers rarely noticed?

A

because lung cancer causes coughing but smokers cough anyways, so they don’t really notice

179
Q

What percentage of patients with lung cancer survive after 5 years of diagnosis?

A

3%, because lung cancer metastasizes very quickly

180
Q

Protruding papulae are found in which organisms?

A

echinoderms

181
Q

What is the atmospheric PO2?

A

160 mm Hg

182
Q

Which is more tolerable, alkalinity or acidity?

A

alkalinity

183
Q

Emphysema affects what factor of Fick’s Law?

A

surface area

184
Q

(T/F) There are nerve endings in our lungs.

A

False, we don’t have nerve endings in our lungs

185
Q

In physiological conditions, how much O2 can blood plasma contain, per liter?

A

3 mL O2 per liter blood plasma

186
Q

In physiological conditions, how much O2 can whole blood contain, per liter?

A

200 mL O2 per liter whole blood

187
Q

Hemoglobin is composed of

A

four polypeptide chains

188
Q

Oxygen-bound hemoglobin is called

A

oxyhemoglobin

189
Q

Where does hemoglobin load up with oxygen?

A

alveolar capillaries of the pulmonary circulation

190
Q

Oxygen-bound hemoglobin that releases oxygen is called

A

deoxyhemoglobin

191
Q

What is the color of deoxyhemoglobin?

A

darker red, but gives a bluish tinge to tissues

192
Q

(T/F) Hemoglobin is exclusively used in vertebrates.

A

False. Used in all vertebrates, but is also used in many invertebrates like annelids, mollusks, echinoderms, flatworms, some protists.

193
Q

What is the oxygen carrier in non-hemoglobin invertebrates?

A

hemocyanin

194
Q

How is hemocyanin different from hemoglobin?

A

uses copper instead of iron to bind O2; not associated with blood cells but is intend a free protein in the circulating fluid (hemolymph) of arthropods and some mollusks

195
Q

What percentage of hemoglobin is oxygenated at PO2 = 100 mmHg when leaving the alveoli?

A

97% of hemoglobin is oxygenated

196
Q

What percentage of hemoglobin is oxygenated at PO2 = 40 mmHg in blood that returns to the heart through the systemic veins?

A

75% of hemoglobin is oxygenated

197
Q

How much of a “reserve” of O2 is there in hemoglobin?

A

In a person at rest, only about 22% of oxyhemoglobin proteins release oxygen, meaning that 78% of oxygen is left as a reserve

198
Q

Why is the large reserve of O2 in hemoglobin important?

A

enables blood to supply needs during exertion AND rest; ensures there’s enough O2 to maintain life for 4-5 min if breathing is interrupted/heart stops pumping

199
Q

What is the PO2 of venous blood during exercise?

A

can drop to 20 mm Hg

200
Q

A second oxygen reserve is found in

A

myoglobin

201
Q

Where is myoglobin found?

A

muscle cells

202
Q

Myoglobin consists of

A

a single polypeptide chain w/ iron atom

203
Q

Which has a higher affinity for O2 - myoglobin or hemoglobin?

A

myoglobin

204
Q

How does myoglobin function as a backup?

A

when hemoglobin levels are exhausted, myoglobin kicks in with extra O2

205
Q

How can animals like the elephant seal stay underwater for long periods of time (in terms of hemoglobin/myoglobin)?

A

because they have high levels of O2 stored in myoglobin in their muscle cells

206
Q

CO2 + H2O yields

A

H2CO3

207
Q

H2CO3 dissociates into

A

HCO3- and H+

208
Q

Where does H2CO3 dissociation occur?

A

inside RBCs

209
Q

What effect does a lower pH have on hemoglobin’s affinity for oxygen?

A

promotes release of O2; shifts Bohr curve to the right

210
Q

What effect does a higher temperature have on hemoglobin’s affinity for oxygen?

A

promotes release of O2; shifts curve to the right

211
Q

What percentage of CO2 is simply dissolved in plasma?

A

8% of blood CO2 is simply dissolved in plasma

212
Q

What percentage of blood CO2 is bound to hemoglobin?

A

20% of blood CO2 is bound to hemoglobin

213
Q

Where does CO2 bind to in hemoglobin?

A

on the protein part (not to the iron parts), so it doesn’t compete with O2

214
Q

What effect does CO2 binding to hemoglobin have on binding to O2?

A

CO2 binding causes hemoglobin’s shape to change which lowers affinity for O2

215
Q

Where is CO2 not dissolved in plasma or bound to hemoglobin found?

A

diffuses into RBCs where it combines with H2O to produce H2CO3

216
Q

Which enzyme catalyzes the combining of CO2 and H2O?

A

carbonic anhydrase

217
Q

What happens to the H+ that results from the dissociation of H2CO3?

A

H+ binds to deoxyhemoglobin

218
Q

What happens to the HCO3- that results from the dissociation of H2CO3?

A

moves out of RBC into plasma via a transporter that exchanges one Cl- for one HCO3-

219
Q

What is the chloride shift?

A

when an HCO3- inside an RBC is replaced with a Cl- via a transporter

220
Q

CO2 is primarily transported in what form?

A

as HCO3-

221
Q

Why is the diffusion of CO2 into the RBCs important?

A

it creates a diffusion gradient that allows more CO2 to move into the plasma from surrounding tissues

222
Q

What is the major buffer of blood plasma?

A

HCO3-

223
Q

What happens to H2CO3 in the lungs?

A

the lower PCO2 causes carbonic anhydrase reaction to proceed in the reverse reaction, which creates H2O and CO2, and CO2 diffuses out and is released in the next exhalation

224
Q

Which two other gases can be transported by hemoglobin?

A

NO and CO

225
Q

NO is important for

A

vessel dilation

226
Q

Why is CO poisonous?

A

because it binds more strongly to hemoglobin than does O2

227
Q

Victims of CO poisoning often have what color skin?

A

bright red skin

228
Q

What happens to HCO3- replaced with Cl- once the blood reaches the alveolar capillaries?

A

diffuses into cell, reacts with H+ to form H2CO3, then decomposes into CO2 + H2O, diffuses into alveolus, exhaled