Chapter 4: prenatal development Flashcards
What is organogenesis?
Process of organ formation starting from 10 weeks
What are the three phases of prenatal development?
- Zygote: fertilization - 2w
- Embryo: 2-10w
- Fetus: 10w-birth
How long does it take for a fertilized egg to implant in the uterus? How is the egg called when it implants?
7 days, it’s called a blastula
What happens in week 2 of prenatal development?
Gastrulation = formation of 3 germ layers
What are the 3 germ layers and what is their future development?
- Ectoderm = skin, hair, nervous system
- Mesoderm = muscles, bones
- Endoderm = organs
What is a morula?
A ball of 16 cells with cell differentiation in the zygote stage
What happens in week 3 of prenatal development?
Neurulation –> formation neural plate –> neural groove –> neural tube
This is the formation of the CNS, where the neural tube is the spinal cord
Which germ layer is important in neurulation?
Ectoderm
When is the first primitive brain developed? Of which parts does it consist?
After 4 weeks, consists of midbrain and forebrain
What happens at 7-8 weeks?
Start of reflexes in spinal cord
What are 2 possible consequences if the neural tube fails to close?
- Open skull/anencephaly
- Open back/spina bifida
What is the forebrain, midbrain and hindbrain in embryo development?
Forebrain: cerebrum + diencephalon
Midbrain: midbrain (brainstem)
Hindbrain: pons + medulla
What is the timeline of cerebral development?
- 9 weeks: start development
- 3 months: mainly reflexive spinal responses
- 4 months: cells cerebral hemispheres migrate
- 6 months: cortex folds –> sulci/gyri
- Brain grows and develops 6 layers
- > 6months: matured cerebral cortex with enough cells, volume has to increase
How does the fetal brain grow after 6 months?
Mainly through synaptogenesis and myelination
What’s the difference between active and quiet sleep in fetuses? How does it develop from 34-38 weeks?
Active = movement, irregular heartbeat, responsive
Quiet = motionless, steady heartbeat
34 weeks: patterns of rest and activity
38 weeks: less active sleep because of brain maturing
Why is active sleep in fetal development important? State 2 reasons
- Stimulation neural networks for maturation nervous system
- Breathing movements important for lung development
Why do sulci and gyri develop? From which week does this start to happen?
Because the volume of our brain is too large, it folds
From 6 months onward
When is the biggest chance of miscarriage?
0-4w: 10%
4-8w: decrease of chance on miscarriage
When is the biggest risk for neural deviations? Why?
From week 3-8, because the CNS is formed through neurulation in that time
What is the rooting reflex? What is its function?
Reflex that causes newborn babies to respond to one of their cheeks being touched by turning head in that direction
Helps to find nipple