chapter 4 - histology Flashcards
the study of tissues
histology
the four major types of tissues
epithelial, connective, muscle, nerve
the tissue that covers, lines, and secretes
epithelial
the tissue that contracts to cause movement
muscle
the tissue that conducts electrical messages
nerve
the tissue that holds things together and fills in spaces
connective
a group of cells working together
tissue
the type of microscope that is used most in histology
electron microscope
tiny microscopic cell extensions that increase the surface area of cells to help with absorption and secretion
microvilli
cell extensions that sweep materials along the cell surface
cilia
longer cell extensions with unknown function
stereocilia
Where in the body is known for having many microvilli?
small intestine
Where in the body is known for having many cilia
airways
Where in the body is known for having stereocilia?
inner ear and male reproductive tract
the term meaning having no blood vessels
avascular
the term meaning having a blood supply
vascular
What major tissue type is avascular?
epithelial
How does the epithelium get its nutrition?
diffusion from the CT beneath it
What is the name of the layer that separates the epithelium from the CT?
basement membrane
What are the two layers of the basement membrane?
basal lamina and reticular lamina
What term is used to describe epithelial cells (particularly columnar) that are empty at the top and full of organelles at the bottom
polar
the specialized connections between epithelial cells
cell junctions
Name the three types of epithelial cell junctions.
- gap junctions
- tight junctions
- desmosomes
Which cell junction is a passageway allowing chemical communication between cells?
gap junction
Which cell junction is water proof due to the fusion of the lipid layers?
tight junction
Which cell junction is reinforced with fibers to make it exceptionally strong?
desmosome
What is a common place to find gap junctions?
smooth and cardiac muscle
What is a common place to find tight junctions?
digestive tract
What is a common place to find desmosomes?
skin and cardiac muscle
the ability of a tissue to regrow
regeneration
the three shapes of epithelial tissue
- squamous - flat
- cuboidal - equally tall as wide
- columnar - taller than wide
the two most common layering arrangements in epithelium
simple - 1 layer
stratified - many layers
the bottom of epithelium - attached surface
basal surface
the exposed or unattached surface of epithelium
apical surface
falsely layered
pseudostratified
epithelium that can stretch or distend
transitional
Where is transitional epithelium found?
urinary bladder
Which is more protective, simple or stratified epithelia?
stratified
Name the two major types of simple squamous epithelium.
- endothelium - inner covering
2. mesothelium - middle covering
Where is endothelium found? Why?
lining cardiovascular and lymphatic vessels to allow diffusion
Where is mesothelim found? Why?
serous membranes - to be slippery
Why is simple squamous the right tissue for alveoli of lungs and capillaries?
to allow diffusion
What is pseudostratified columnar epithelium always topped with?
cilia
Why does pseudostratified epithelium appear layered?
nuclei are at various heights but each cell actually touches the basement membrane
the cells that are reproducing (2 terms)
- stem cells
2. germinative cells (germ cells)
Where in your body do you have stratified squamous epithelium?
skin, lining of mouth and throat, lining of anus, lining of vagina - places with abrasion
What is the difference between keratinized and non-keratinized epithelia?
keratinized - waterproof and dry - filled with keratin
a group of cells that secrete
gland
a unicellular gland
goblet cell
What do goblet cells produce, and what is the function?
mucus - lubricate, prevent drying, trap dirt
Name the two major types of multicellular glands.
- endocrine
2. exocrine
glands with ducts to dump their secretions onto an epithelial surface
exocrine
glands without ducts, secretions called hormones go into the blood to travel around the entire body
endocrine
Name the three functional types of exocrine glands.
- merocrine
- apocrine
- holocrine
Which exocrine secretion is the most watery because it is produced only by exocytosis of secretory vesicles? Give 2 examples.
merocrine (eccrine)
- perspiration
- saliva
Which exocrine gland is thicker because part of the cytoplasm is released with the secretion? Give 2 examples.
apocrine
- apocrine sweat - armpits and anogenital area
- breast milk
Why does apocrine sweat stink unlike merocrine sweat?
bacteria feed on apocrine sweat, and the bacteria stink
Which exocrine gland secretion is the thickest? Give an example.
holocrine
1. oil (sebum)
Why do holocrine glands have so much mitosis going on?
The cells need to be replaced.
What is the study of cells that fall off?
exfoliative cytology
Name two tests that are examples of exfoliative cytology, and say what each studies.
- Pap smear - tests for cervical cancer
2. amniocentesis - tests for chromosome errors in developing babies
Name the three major types of connective tissue (CT).
- CT proper
- fluid CT
- supporting CT
Name the two major types of CT proper, and give examples of each.
- loose CT proper - adipose (fat)
2. dense CT proper - ligaments and tendons
Name the two types of dense CT proper, and explain how they get their names with examples.
- dense regular - fibers run in same direction
- ligaments and tendons - dense irregular - fibers run in multiple directions
- joint capsule
Name two examples of supporting CT, and explain how they are related.
- cartilage - flexible
- bone - calcified (hardened)
Bone begins as cartilage.
Name two examples of fluid CT, and explain how they are related.
- blood - in blood vessels
- lymph - in lymphatic vessels
Lymph is formed by blood plasma that leaks out of blood vessels, bathes tissues to give them nutrients and oxygen, and then is picked up and filtered through the lymph nodes
embryonic CT - where all adult CT begins
mesenchyme
What is the one CT that is avascular, and how does this have an effect on this tissue?
cartilage - doesn’t heal well
What are the three types of fibers in CT? Describe each.
- collagen - straight and strong
- elastic - thin and flexible, snap back
- reticular - extensive, fine and branched
What is the fluid in CT? What is it like, and why?
ground substance - viscous to slow bacterial movement
together, the fibers and ground substance make up the what of CT?
matrix
immature CT cells that produce fibers
fibroblasts
immature cartilage cells/mature cartilage cells
chondroblasts/chondrocytes
immature bone cells/mature bone cells
osteoblasts/osteocytes
immature blood cell that makes all other blood cells
hematopoietic stem cell
large white blood cells that eat germs and stay in one place - large white blood cells that eat germs and move around
fixed macrophages - free macrophages
small white blood cells that eat germs
microphages
cells that make histamine and heparin to cause swelling
mast cells
white blood cells that make antibodies
lymphocytes
cells that produce a brown, black pigment
melanocyte
fat cell
adipocyte
another name for loose CT
areolar
another name for dense CT
collagenous
swelling
edema
What is the difference between brown fat and yellow or white fat
brown fat - baby fat - has many mitochondria and a good blood supply for warming babies that can’t shiver
What about adipocytes makes it hard to lose weight but easy to gain weight?
When adipocytes shrink, they send messages to your body to slow down your metabolism because they think you are starving. Mesenchyme will readily make new fat cells.
Where does the fat come from that fills the adipocytes?
taking in more calories than you burn - store excess as fat
Why do fat cells look empty?
The lipid droplet pushes the organelles out of the middle along the edge.
What are the functions of stored fat?
insulate, cushion, store energy
Where does fat accumulate?
any areolar tissue - superficial fascia
What connects bone to bone?
ligament
What connects muscle to bone?
tendon
a sheetlike tendon
aponeurosis
Name the three major types of cartilage, and describe each.
- hyaline cartilage - glassy appearance - can’t see fibers
- elastic cartilage - very flexible due to elastic fibers
- fibrocartilage - very tough due to collagen
Which type of cartilage is the most common? Where is it found
hyaline - at ends of bones, between ribs and sternum
Give three places we find elastic cartilage.
tip of nose, ears, epiglottis
Give two places we find fibrocartilage.
intervertebral discs, knee cartilage
What are the spaces that cartilage and bone cells reside in?
lacunae
What is the outer layer of a cartilage?
perichondrium
What is cartilage made mostly of?
water
What two chemicals are common in cartilage?
chondroiten sulfate and hyaluronic acid
What is the name for bone?
osseous tissue
Give two ways bone is different from cartilage.
calcified, blood vessels (vascular)
What are the tiny passageways that connect bone cells?
canaliculi
What are the three formed elements in blood, and what does each do?
- erythrocytes (RBC) - carry oxygen
- leukocytes (WBC) - fight infection
- platelets - clot
What makes blood different from other CT?
watery matrix - no fibers unless clotting
the liquid part of blood, contains dissolved oxygen , nutrients, hormones, wastes, antibodies…
plasma
Name and describe the three major blood vessels.
- arteries - muscular - carry blood away from heart
- veins - medium thick with valves - carry blood to heart
- capillaries - thinnest - allow diffusion - connect arteries and veins
Which formed element should be most numerous in blood?
RBC
When do WBC become more numerous?
when sick
Why are there so many types of WBC?
different types of inections
Name the two cell types in nerve tissue, and tell what each does.
- neurons - conduct messages
2. neuroglia - support, feed, and protect neurons
What are the three major parts of a typical neuron?
- cell body (soma or perikaryon) - holds most organelles
- axons - large fibers that carry messages away from cell body
- dendrites - smaller and more numerous fibers that bring message into cell body
Name the three major types of muscle tissue.
- cardiac - heart
- skeletal - attached to bones
- smooth - in hollow organs
Which muscle is striated, voluntary, multinucleate, cylinders?
skeletal
Which muscle is striated, involuntary, uninucleate and branched with intercalated discs?
cardiac
Which muscle in nonstriated, involuntary, uninucleate, and fusiform (torpedo-shaped)
smooth
What word means under conscious control?
voluntary
What word means not under conscious control?
involuntary
What word means banded or striped?
striated
What are the specialized connections in cardiac cells - made of gap junctions and desmosomes?
intercalated discs
What type of membrane lines cavities that open to the outside? Give examples.
mucous - respiratory and digestive mucosa
What type of membrane lines cavities that do not open to the outside? Give examples.
serous - peritoneum, pericardium, pleural
What is the membrane that makes up your skin?
cutaneous membrane
What is the membrane around your joints?
synovial membrane
What are the three steps in healing?
- inflammation rushes materials to the site
- organization - restores blood supply and
- regeneration and fibrosis - closes wound
Do all tissues repair at the same level? What ones repair well? What ones don’t repair at all?
no - epithelium, loose CT, dense irregular CT, and blood regenerate well - heart and brain - don’t repair at all
What are 3 cells that move to a wound to begin the healing?
white blood cells to eat germs
fibroblasts to make fibers
epithelial germ cells to make new skin
Why is it good for a wound to bleed a little?
flush out the germs
The clot that dries on the surface and stops the bleeding
scab
the healing tissue, pink with tiny capillaries
granulation tissue
scarring
fibrosis
What does scar tissue do to organs and joints?
impairs function
scar tissue connecting adjacent abdominopelvic organs
adhesions
a fertilized egg
zygote
the early cell divisions
cleavage
the three primary germ layers and what each becomes
endoderm - respiratory and digestive lining (mucosae)
ectoderm - skin and nerves
mesoderm - muscle and bone
What tissue forms from all three germ layers? Name them.
epithelium
mesothelium
endothelium
a tumor or new growth
neoplasm
a non-cancerous tumor
benign
a cancerous tumor
malignant
the spreading of a cancer to a new location - how does it often spread
metastasis - often through lymphatics
cancer causing factors
carcinogens
cancer genes
oncogenes/protooncogenes
a cancer doctor
oncologist
removing a sample tissue to look for cancer
biopsy
when there are no longer any signs of cancer
remission
a description of how progressed the cancer is
staging
the three most common treatments for cancer
surgery
radiation
chemotherapy
Why do cancer treatments have so many side effects?
kill healthy cells
cancers of epithelia - 90%
carcinomas
cancers of CT and muscle
sarcomas
neoplasms in glands whether or not malignant
adenomas
a very large scar
keloid
an inherited condition of abnormal CT - extremely tall with long fingers… and weak heart and blood vessels
Maran’s syndrome
CT right under the skin - 3 terms
subcutaneous layer, hypodermis or superficial fascia
CT between muscles and organs
deep fascia