Chapter 32 Part 6 Flashcards
Is an Inflammatory disease of the joint caused by auto immune response to external trigger
Rheumatoid arthritis
It occurs at any age but most common among older adults the cause is unknown but hormonal, environmental, genetics, or infectious agent can
Trigger an underlying autoimmune
reaction
Rheumatoid arthritis
What happens with rheumatoid arthritis
An abnormal immune response causes in and limitary reaction of the synovial membrane
When An abnormal immune response causes in and limitary reaction of the synovial membrane it causes
Vasodilation,
increase permeability,
formation of Exudate cause red,
swollen joints
Immunoglobulin g appears in the blood and synovial fluid
What appears in the blood with Rheumatoid arthritis
Immunoglobulin g
And synovial fluid
As Rheumatoid arthritis Progresses what forms
Pannus
Is granulation tissue derived from the synovium that spreads over the articular cartilage
Pannus
What do pannus release
What happened to the cartilage
Enzymes and inflammatory mediators that destroy cartilage
It becomes eroded and cuts of nutrition to the cartilage
When pannus is between the bone it causes
The bone to be come fibrotic causing ankylosis
What happened to the joint when you have rheumatoid arthritis
Deformity becomes a parent
Exacerbation causes more damage
Atrophy of muscles around the joints
Tendons and ligaments stretch in the joint becomes unstable
Contracture
Where can the subcutaneous nodules occur
And where do the nodules occur
Over bony prominences
Pleura
Heart ❤️ valve
Eyes
Signs and symptoms of RA
Where are they mostly common signs and symptoms of RA
Joint pain, warmth,
Edema
Limitation of motion, stiffness in multiple joints in the morning lasting more than 1 hour
what are some systemic symptoms
low-grade fever
anorexia= wt loss
malaise
iron deficiency anemia
what do RA or immobility of joints interferes with
self-care activities necessary to lead independent lifestyle
(limitation of ADLs)
how is RA Dx
by history of arthritis pain 3 or more joints that lasts more than 6 weeks
what type of blood test indicates that the pt has RA
positive RF
anti-cyclic peptide/protein
protein antibody test (CCP or CRP)