Chapter 23 Management of Patients with Coronary Vascular Diseases Flashcards
What is the leading cause of death in the United States?
Cardiovascular Disease
Which type of cardiovascular disease is most prevalent in disease?
Coronary artery disease (CAD)
Non-modifiable Risk Factors for CAD
Family Hx
Gender (Assigned at Birth): Onset of disease is earlier in males than in females
Age
Male: > 45 y.o
Female: > 55 y.o.
Race: Greater genetic risk in African-Americans than in Caucasians
Primary (genetic) Hypercholesterolemia
Modifiable Risk Factors for CAD
Hyperlipidemia (LDL) and/or Low HDL
Elevated triglycerides
Smoking/tobacco use
HTN
Diabetes mellitus
Obesity
Physical Inactivity
Metabolic Syndrome: Combo of 3 modifiable physiological factors
Chronic Inflammatory Conditions: Rheumatoid arthritis, lupus, HIV/AIDS, etc
Chronic Kidney Disease (CKD)
(T/F) True or False: CAD is a progressive disease process
True
Early Stages of CAD
Atherosclerosis & Stable Angina (pain associated w/MI)
Atherosclerosis
Abnormal accumulation of lipid deposits & fibrous tissue w/in arterial walls & lumen
Atherosclerosis Process
1) Starts w/ injured vessel
2) Injured tissue can no longer produce antithrombotics & vasodilation agents
3) Inflammatory response begins and leads to a build-up of cells and lipids in the vessel (fatty streak)
4) Decreased blood flow in vessel due to narrowed opening
Atheromas
Lipid deposits/ plaques that protrude in the arterial lumen
Vulnerable Plaque
When the fibrous cap becomes thin with ongoing inflammation
Myocardial Infarction (MI)
AKA Heart Attack
Occur when there is occlusion of the coronary artery that leads to ischemia or necrosis of the myocardium
THIS IS AN EMERGENCY!!!
Additional Risk Factors for Atherosclerosis
Diabetes Mellitus
Peripheral Artery Disease (PAD)
Abdominal Aortic Aneurysm (AAA)
Carotid Artery Disease
Presence of disease in other body arteries presents a high likelihood that there is disease in the coronary arteries as well
Dangers of Atherosclerosis
Progressive and can lead to ischemia due to narrowing in the coronary arteries
Can lead to extensive myocardial damage and scarring; later causing angina/heart failure/heart attacks, or even sudden cardiac death
Ischemia
Insufficient tissue oxygenation
Clinical Manifestations of Atherosclerosis
May be nothing/chest pain
Epigastric pain
Pain in jaw, shoulder, or arm
Clinical Manifestations of Atherosclerosis in Women
Indigestion
Nausea
Palpitations & numbness
SOB
Angina pectoris
Refers to chest pain that is brought about by myocardial ischemia
- Usually characterized by pain or pressure
Angina Pectoris Clinical Manifestations
Vice-like pain in the chest (weight on chest, crushing)
Pts w/ DM may have neuropathy & feel less pain
Older patients may not have pain due to diminishing tissue sensation from aging
Chest/neck/jaw/shoulder/arm pain
Changes in: BP, N/V, pallor, tachycardia, tachypnea, vasoconstriction
Do the symptoms improve w/ NTG?
Atypical Angina Clinical Manifestations in Women
Chest pain, discomfort, pressure or squeezing (like there’s a weight sitting on you)
Unusual upper body pain/discomfort in one or both arms, back, shoulder, neck, jaw or upper portion of stomach
Breaking out in a cold sweat
Lightheadedness or sudden dizziness
Nausea
Unusual fatigue
SOB
Cause of Angina Pectoris
Usually caused by significant coronary atherosclerosis
- ANY reduction of blood flow to the heart (coronary spasm, extreme cold, hypotension)
Common Causes of Angina Pectoris
Atherosclerotic disease-> obstruction in at least 1 of the coronary arteries
Myocardial Ischemia: Insufficient tissue oxygenation (can lead to damage)
Any reduction of blood flow to the heart (coronary spasm, hypotension, extreme cold…)
Stable Angina
Can be managed w/lifestyle changes
Predictable/constant w/exertion
Relieved by rest and/or NTG
Common Exacerbating Factors of Stable Angina
Exercise: Increases O2 demand
Extreme cold: Vasoconstriction will decrease blood flow
High-stress situation: Increase in BP, HR, & cardiac work
Substances: Tobacco, caffeine, some illicit drugs
Unstable Angina
AKA preinfarction angina or crescendo angina
Occurs w/ sudden reduction in coronary blood flow likely from a ruptured atherosclerotic plaque, the vessel is not necessarily occluded
Unstable Angina (Symptoms)
Symptoms increase in frequency/severity
Unrelieved by rest and/or NTG
Not related to usual causes, often an indicator of impending MI
HEALTH EMERGENCY! ACT QUICKLY!
Variant Angina (Prinmetal’s angina)
Pain at rest w/ reversible ST-segment elevation
- Thought to be caused by coronary artery vasospasm
Silent Ischemia
Objective evidence of ischemia (such as ECG changes w/ stress test), but patient reports no pain
Intractable/ Refractory Angina
Severe incapacitating chest pain
Angina Pectoris Treatment Goal
Balance the O2 supply & demand